Mnexspike (2026-2027) PF (cvx 334) (2026-2027)

COVID-19 is a serious illness caused by a virus called SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2). It spreads from person to person through the air.

COVID-19 can affect your lungs or other organs. Symptoms can be mild or serious and may include fever, chills, cough, sore throat, shortness of breath, tiredness, body aches, headache, loss of taste or smell, runny or stuffy nose, nausea, vomiting, or diarrhea.

Mnexspike vaccine is used to prevent COVID-19 in people:

• age 65 and older; or
• 12 years through 64 years of age who have a health condition that increases their risk of severe COVID-19.

The COVID-19 vaccine does not contain coronavirus and cannot give you COVID-19. This vaccine will not treat an active COVID-19 infection.

Like any vaccine, the COVID-19 vaccine may not provide protection in every person.

Read all vaccine information sheets provided to you.

Mnexspike COVID-19 vaccine is given to people who are at least 12 years old as a single injection into a muscle.

A single dose of Mnexspike COVID-19 vaccine is given at least 3 months after the last dose of any COVID-19 vaccine.

The doctor or vaccination provider will decide if an immunocompromised person needs extra doses.

Continue using infection control methods when you are in public or around others who may not have been vaccinated. This includes social distancing, hand-washing, wearing protective face coverings, disinfecting surfaces you touch often, and not sharing personal items with others.

Getting a COVID-19 vaccine will not make you test positive on a coronavirus test. However, once your body develops immunity to COVID-19, you could test positive on an antibody test (a test to check for immunity from previous exposure to coronavirus).

It is not known how long this vaccine will protect you from COVID-19 infection. It is also not known how long immunity lasts in a person who has been infected with and recovered from COVID-19. The COVID-19 vaccine is still being studied, and all of its risks are not yet known. Updated federal public health recommendations can be found at https://www.cdc.gov/covid/index.html.

Getting infected with COVID-19 may be much more harmful to your health than getting this vaccine.

You should not get this vaccine if you have had a severe allergic reaction after a previous dose of MNEXSPIKE, SPIKEVAX, Moderna COVID-19 vaccine, or if you have had a severe allergic reaction to any ingredient in this vaccine.

If you are infected with COVID-19, waiting for test results, or have been exposed to someone with COVID-19: you may not be able to receive this vaccine until you have no symptoms and/or your required quarantine period has ended. Receiving this vaccine will not make you less contagious to others if you are infected with COVID-19 but do not have symptoms.

Ask your doctor if you are unsure about any COVID-19 treatments you have received.

Tell your vaccination provider if you:

• have any allergies;
• have had inflammation in or around your heart (myocarditis or pericarditis);
• have a fever;
• have bleeding problems or are using a blood thinner;
• have a weak immune system due to a disease or certain medicines (this vaccine may not be as effective if you are immunosuppressed);
• are pregnant, plan to become pregnant, or are breastfeeding;
• have received any other COVID-19 vaccine or are scheduled to receive a vaccine; or
• have fainted after receiving an injection.

Get emergency medical help if you have signs of an allergic reaction: hives, difficulty breathing, swelling of your face, lips, tongue, or throat.

The vaccination provider may want to monitor you for a short time after the injection to ensure you do not have an allergic reaction or faint. You will receive quick treatment if there is a reaction right after getting the vaccine.

Not all possible side effects are known. Getting infected with COVID-19 may be much more harmful to your health than receiving this vaccine.

Some people (most often males aged 12 to 24 years) who received this vaccine experienced inflammation of the heart muscle or the lining around the heart after vaccination, usually within the first week. Seek medical attention immediately if you have any of the following symptoms, especially within the first two weeks:

• chest pain;
• shortness of breath; or
• fast or pounding heartbeats, fluttering in your chest.

Common side effects of Mnexspike (2026-2027) PF (cvx 334) may include:

• pain, redness, hardness, or swelling at the injection site;
• fever, chills, nausea, vomiting, feeling tired;
• swelling or tenderness under the arm where the injection was given; or
• headache, muscle pain, joint pain.

This is not a complete list of side effects, and others may occur. Call your doctor for medical advice about side effects. You may report vaccine side effects to the US Department of Health and Human Services at 1-800-822-7967.

You can also use a smartphone-based program called V-safe to communicate with the Centers for Disease Control and Prevention (CDC) about any health issues you experience after receiving a COVID-19 vaccine: www.cdc.gov/vsafe.

Contact your vaccination provider or health department if you miss your dose.

An overdose of this vaccine is not likely to happen.

Do not get other vaccines without first talking to a doctor.

Before getting this vaccine, inform your vaccination provider about all the other vaccines you have had. Other medications may impact this vaccine, including prescription and over-the-counter medicines, vitamins, and herbal products. Let your doctor know about all the other medications you are taking.