Mometasone (Implantation)

Mometasone implant is used to treat chronic rhinosinusitis with nasal polyps (CRSwNP) in patients who have had surgery in their ethmoid sinus. This is a steroid medicine.

This medicine is to be given only by your doctor or under their direct supervision.

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly and to check for unwanted effects.

This medicine may cause other nasal problems. Check with your doctor right away if you have bleeding, holes, infection, or irritation inside the nose.

Check with your doctor right away if blurred vision, difficulty in reading, or any other change in vision occurs during treatment with this medicine. Your doctor may want your eyes to be checked by an ophthalmologist (eye doctor).

This medicine may cause serious allergic reactions, including angioedema, which can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, hoarseness, trouble breathing or swallowing, or any swelling of your hands, face, or mouth while you are using this medicine.

You may get infections more easily while using this medicine. Tell your doctor right away if you have been exposed to someone with chickenpox or measles. Also tell your doctor if you develop white patches or sores in your nose while you are using this medicine.

Using too much of this medicine or using it for a long time may increase your risk of having adrenal gland problems. Talk to your doctor right away if you have darkening of the skin, diarrhea, dizziness, fainting, loss of appetite, mental depression, nausea, skin rash, unusual tiredness or weakness, or vomiting.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

In deciding to use a medicine, you and your doctor will weigh the risks against the benefits. Here are important points to consider for this medicine:

Allergies

Inform your doctor if you have ever had any unusual or allergic reactions to this medicine or any other medicines. Also, let your healthcare professional know if you have any other allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, carefully read the label or package ingredients.

Pediatric

The effects of mometasone implant in children have not been studied enough. Safety and effectiveness have not been established.

Geriatric

Studies have not found any specific problems in elderly patients that would limit the usefulness of mometasone implant.

Breast Feeding

There are no adequate studies in women to determine the risk to infants when using this medication during breastfeeding. Consider the potential benefits and risks before using this medication while breastfeeding.

Interactions with Medicines

Some medicines should not be used together at all, while others may be used together with caution. If you are receiving this medicine, it is very important for your healthcare professional to know if you are taking any of the medicines listed below. The following interactions have been chosen based on their potential significance, but this list is not complete.

Using this medicine with any of the following medicines is not recommended. Your doctor may choose not to treat you with this medication or adjust your other medicines.

• Desmopressin

Using this medicine with any of the following medicines is usually not recommended, but may be necessary in some cases. If both medicines are prescribed, your doctor may change the dose or how often you use one or both.

• Aspirin
• Atazanavir
• Bemiparin
• Cobicistat
• Darunavir
• Lutetium Lu 177 Dotatate
• Macimorelin
• Nadroparin
• Nirmatrelvir
• Ritonavir
• Sargramostim
• Somatrogon-ghla

Using this medicine with any of the following medicines may increase the risk of certain side effects, but using both may be the best treatment for you. If both are prescribed, your doctor may change the dose or frequency of one or both medicines.

• Auranofin
• Ketoconazole

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used around the time of eating food or certain types of food due to potential interactions. Using alcohol or tobacco with some medicines may also cause interactions. Talk to your healthcare professional about using your medicine with food, alcohol, or tobacco.

Other Medical Problems

Other medical issues may affect the use of this medicine. Make sure to tell your doctor if you have any other medical problems, especially:

• Cataracts, history of or
• Glaucoma, history of or
• Increased pressure in the eye, history of—Use with caution. May worsen these conditions.

• Chickenpox (including recent exposure) or
• Herpes simplex (virus) infection of the eye or
• Infections (virus, bacteria, or fungus), of any type or
• Measles (including recent exposure) or
• Tuberculosis, active or history of—This medicine can lower your body's ability to fight these infections.

• Injury to the nose, recent or
• Nose surgery, recent or
• Sores or ulcers in the nose, recent—This medicine may hinder proper healing of these issues.

• Severe liver disease—Use with caution. The effects may be stronger due to slower removal of the medicine from the body.

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do, they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• Chest tightness
• chills
• cough producing mucus
• earache
• ear congestion
• feeling faint
• fever
• headache
• lightheadedness
• loss of voice
• noisy breathing
• nosebleeds
• pain or tenderness around the eyes and cheekbones
• redness or swelling in the ear
• sneezing
• sore throat
• stuffy or runny nose
• trouble breathing

Less common

• Blurred vision
• body aches or pain
• fast heartbeat
• hives, itching, skin rash
• hoarseness
• irritation
• joint pain, stiffness, or swelling
• muscle weakness
• redness of the skin
• swelling of the eyelids, face, lips, hands, or feet
• trouble swallowing
• unusual tiredness or weakness

Incidence not known

• Burning, redness, swelling, or irritation around or inside your nose
• darkening of the skin
• diarrhea
• dizziness
• eye pain
• loss of appetite
• mental depression
• nausea or vomiting
• sores or white patches inside the nose or mouth

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

In the U.S.

• Propel

Available Dosage Forms:

• Implant

Therapeutic Class: Anti-Inflammatory

Pharmacologic Class: Mometasone

Your doctor will insert this medicine into one of your sinuses using a Delivery System. It will dissolve and slowly release the medicine for up to 90 days. Your doctor may also remove the implant at Day 90 or earlier.

Use saline irrigations (nasal wash) or nasal sprays regularly while having this implant.

Be extra careful when sneezing and avoid forceful nose blowing during treatment with this medicine. The implant softens over time and may accidentally be removed from your nose. Call your doctor right away if you think the implant has been removed from your nose.

• Can asthma inhalers cause a sore throat?
• What causes Plaque Psoriasis?