Monoject Prefill Advanced (flush)

Monoject Prefill Advanced is a blood thinner that helps stop blood clots from forming.

Monoject Prefill Advanced is used to clean out an intravenous (IV) catheter, which helps stop the tube from getting blocked after you have received an IV infusion.

Monoject Prefill Advanced should not be used to treat or prevent blood clots in the body. A separate product is available for this purpose.

Monoject Prefill Advanced may also be used for other reasons not mentioned in this medication guide.

Monoject Prefill Advanced should not be used to treat or prevent blood clots in the body. A separate product is available for this purpose.

You should not use Monoject Prefill Advanced if you have uncontrolled bleeding or a severe lack of platelets in your blood.

Monoject Prefill Advanced can cause bleeding. Call your doctor right away if you notice easy bruising or unusual bleeding, such as a nosebleed, black or bloody tarry stools, or any bleeding that does not stop.

Tell your doctor about all medicines you are using. This includes prescription, over-the-counter, vitamin, and herbal products. Using certain medicines while you are using Monoject Prefill Advanced can make you bleed more easily.

You should not use Monoject Prefill Advanced if you are allergic to it, or if you have:

• a severe lack of platelets in your blood; or
• uncontrolled bleeding.

To make sure Monoject Prefill Advanced is safe for you, tell your doctor if you have:

• any type of allergy;
• an infection of the lining of your heart (also called bacterial endocarditis);
• uncontrolled high blood pressure;
• recent history of heart attack, stroke, cancer, or surgery;
• a bleeding or blood clotting disorder, such as hemophilia;
• a stomach or intestinal disorder;
• congestive heart failure;
• kidney disease;
• liver disease; or
• if you are having a menstrual period.

It is not known whether Monoject Prefill Advanced will harm an unborn baby. Tell your doctor if you are pregnant.

Do not use Monoject Prefill Advanced without telling your doctor if you are breast-feeding a baby.

Women over 60 years of age may be more likely to have bleeding episodes while using Monoject Prefill Advanced.

Do not use Monoject Prefill Advanced in a newborn baby (less than 1 month old). Do not use this medicine in any child without your doctor's advice.

Get emergency medical help if you have signs of an allergic reaction: nausea, vomiting, sweating, hives, itching, trouble breathing, swelling of your face, lips, tongue, or throat, or feeling like you might pass out.

Monoject Prefill Advanced can cause bleeding. Call your doctor right away if you have easy bruising or unusual bleeding, such as a nosebleed, black or bloody tarry stools, or any bleeding that will not stop.

Monoject Prefill Advanced may cause serious side effects. Stop using Monoject Prefill Advanced and call your doctor right away if you have:

• signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance;
• signs of a blood clot in the lung--chest pain, sudden cough, wheezing, rapid breathing, coughing up blood;
• signs of a blood clot in your leg--pain, swelling, warmth, or redness in one or both legs;
• a light-headed feeling, like you might pass out;
• skin changes in your arms, legs, hands, or feet; or
• (in an infant) extreme drowsiness, weakness, or gasping for breath.

Less serious side effects are more common, and you may have none at all.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Monoject Prefill Advanced is injected directly into the catheter lock of your IV (intravenous) line. You may be shown how to use this medicine at home.

Do not use Monoject Prefill Advanced if you do not fully understand how to flush your IV line and properly dispose of used needles, IV tubing, and other items used to inject your medicines. Follow your doctor's instructions.

Do not use Monoject Prefill Advanced if it has changed colors or has particles in it. Call your pharmacist for a new prescription.

Use a disposable needle and syringe only once. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof "sharps" disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.

Store at room temperature away from moisture and heat.

Call your doctor for instructions if you forget to use Monoject Prefill Advanced (flush) to flush your IV line.

Seek emergency medical help or call the Poison Help line at 1-800-222-1222.

Talk to your doctor before using a nonsteroidal anti-inflammatory drug (NSAID) for pain, arthritis, fever, or swelling. This includes aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib (Celebrex), diclofenac, indomethacin, meloxicam, and others. Taking an NSAID with Monoject Prefill Advanced may increase your risk of bleeding.

Tell your doctor about all the medicines you are currently taking and any that you start or stop using, especially other medicines that prevent blood clots.

Other drugs may interact with heparin (flush), including prescription and over-the-counter medicines, vitamins, and herbal products. Inform each of your health care providers about all the medicines you are using now and any medicine you start or stop using.