Motixafortide

Motixafortide is used together with another medicine to help raise the number of stem cells available for collection before a stem cell transplant in adults with multiple myeloma.

Motixafortide may also be used for reasons not mentioned in this medication guide.

Follow all directions on your prescription label and read all medication guides or instruction sheets.

Motixafortide is injected under the skin by a healthcare professional.

Doses are based on weight. Your dose may change if you gain or lose weight.

You may be given other medications to help prevent serious side effects or allergic reactions. Keep taking these medicines for as long as your doctor has prescribed.

You will be monitored for one hour to ensure you do not have an allergic reaction.

Your blood will need to be tested frequently.

Follow all storage instructions provided with motixafortide. Your pharmacist can provide more information about how to store this medicine.

Use only as instructed. Inform your doctor if you are taking other medicines, have other medical conditions, or have any allergies.

You should not use motixafortide if you are allergic to it.

Motixafortide should not be used by people with leukemia.

Tell your doctor if you have or have ever had:

• blood or bone marrow cancer.

You will need to take a pregnancy test before starting treatment with motixafortide.

It may harm an unborn baby. Do not use if you are pregnant. Use effective birth control while taking motixafortide and for at least 8 days after your last dose. Inform your doctor if you become pregnant.

Do not breastfeed while using motixafortide, and for at least 8 days after your last dose.

Get emergency medical help if you have signs of an allergic reaction: hives, difficulty breathing, swelling of your face, lips, tongue, or throat.

Motixafortide may cause serious side effects. Call your doctor immediately if you have:

• chills;
• vomiting, nausea;
• itching, rash; or
• flushing (sudden warmth, redness, or tingly feeling).

Common side effects of motixafortide may include:

• pain, bruising, swelling, redness, itching, or irritation where the medicine was injected;
• flushing; or
• back pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Usual Adult Dose for Multiple Myeloma:

1.25 mg/kg via slow (approximately 2 minutes) subcutaneous injection 10 to 14 hours prior to the initiation of the first apheresisComments:-Premedicate all patients before each dose of this drug to reduce the risk of hypersensitivity and injection site reactions. Administer approximately 30 to 60 minutes before injection of this drug:---Diphenhydramine (12.5 mg IV or 25 mg to 50 mg orally, or another H1-antihistamine)---H2 blocker (e.g., famotidine)---Leukotriene inhibitor (e.g., montelukast)---The addition of an analgesic medication (e.g., acetaminophen) to the premedication regimen is recommended.-A second dose of this drug can be administered 10 to 14 hours before a third apheresis, if necessary-Inject filgrastim at a dose of 10 mcg/kg of the patient's actual body weight subcutaneously once a day for 4 days leading up to the initial dose of this medication, and then on each day prior to every apheresis session.-Dosing is based on actual body weight.-If required, a second dose of this medication can be administered 10 to 14 hours before a third apheresis procedure.Use: To mobilize hematopoietic stem cells to the peripheral blood for collection and subsequent autologous transplantation in patients with multiple myeloma

Call your doctor for guidance if you miss an appointment for your motixafortide injection.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Follow your doctor's instructions about any restrictions on food, drinks, or activities.

Other drugs may affect motixafortide, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.