MPI DTPA (Inhalation, Intravenous)

Technetium Tc 99m pentetate injection is a radiopharmaceutical. Radiopharmaceuticals are radioactive agents that may be used to find and treat certain diseases or to study how the body's organs work.

Technetium Tc 99m pentetate injection is used to help your doctor see an image of your kidneys and check how well they are functioning. It is also used to help your doctor see an image of your brain.

Technetium Tc 99m pentetate injection is also used to help your doctor see an image of your lungs, to check how well they are working and to evaluate patients with blood clots in the lungs.

This medicine is to be given only by or under the direct supervision of a doctor who has specialized training in nuclear medicine.

It is very important that your doctor monitors you closely while you are receiving this medicine. This will help your doctor determine if the medicine is working correctly and decide if you should keep using it.

While using this medicine, you may be exposed to radiation. Discuss any concerns you have about this with your doctor.

This medicine may cause lung or breathing issues. Inform your doctor if you experience a cough, difficulty breathing, noisy breathing, shortness of breath, or tightness in your chest.

In deciding to use a diagnostic test, any risks of the test must be weighed against the benefits it will provide. This is a decision you and your doctor will make together. Other factors may also affect test results. For this test, consider the following:

Allergies

Inform your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also let your healthcare professional know if you have any other allergies, such as to foods, dyes, preservatives, or animals. For over-the-counter products, read the label or package ingredients carefully.

Pediatric

Studies conducted so far have not shown any specific problems that would limit the usefulness of technetium Tc 99m pentetate injection in children for imaging the lungs and kidneys. Safety and effectiveness have not been established in children for imaging the brain.

Geriatric

While appropriate studies on the effects of technetium Tc 99m pentetate injection in older adults have not been performed, there have been no specific problems documented for this age group. However, older patients are more likely to have age-related liver, kidney, or heart issues, which may require caution and a dose adjustment for patients receiving this medicine.

Breast Feeding

There are no adequate studies in women to determine the risk to infants when using this medication while breastfeeding. Consider the potential benefits and risks before taking this medication during breastfeeding.

Interactions with Medicines

Some medicines should not be used together at all, while in other cases, two different medicines may be used together even if an interaction could happen. In these situations, your doctor may want to adjust the dose, or other precautions may be needed. Inform your healthcare professional if you are taking any other prescription or over-the-counter (OTC) medicine.

Interactions with Food/Tobacco/Alcohol

Some medicines should not be taken around the time of eating food or specific types of food due to possible interactions. Using alcohol or tobacco with certain medicines may also lead to interactions. Talk to your healthcare professional about taking your medicine with food, alcohol, or tobacco.

Other Medical Problems

Having other medical problems may affect the use of this diagnostic test. Be sure to tell your doctor if you have any other medical issues, especially:

• Lung or breathing problems (e.g., asthma)—Use with caution. This may worsen your condition.

• Chronic obstructive pulmonary disease (COPD)—The quality of the lung scan may be affected in patients with this condition.

• Kidney disease—The quality of the kidney or brain scan may be affected in patients with this condition.

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do, they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Incidence not known

• Bluish color of fingernails, lips, skin, palms, or nail beds
• blurred vision
• chills
• confusion
• cough
• difficulty with swallowing
• dizziness
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• fast, pounding, or irregular heartbeat or pulse
• fever
• headache
• hives, itching, skin rash
• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• pounding in the ears
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• throat irritation
• tightness in the chest
• unusual tiredness or weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

• Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
• nausea
• vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

In the U.S.

• An-DTPA
• MPI DTPA

A doctor or other trained health professional will give you this medicine. It is given through a needle placed into one of your veins before you have a brain or kidney scan. It may also be given using a nebulizer before you have a lung scan.

You will need to rinse your mouth, cough, and spit out the medicine from your throat after receiving it using a nebulizer.

You will need to urinate right away and as often as you can for 4 to 6 hours after receiving this medicine. Drink plenty of fluids before and after receiving this medicine so you will pass more urine. This will help flush the medicine from your body.