Mucinex Nightshift Cold and Flu Clear and Cool

Acetaminophen is used to relieve pain and reduce fever. Dextromethorphan helps to suppress coughs. Phenylephrine works as a decongestant. Triprolidine acts as an antihistamine.

Mucinex Nightshift Cold and Flu Clear and Cool is a combination medicine that treats headache, fever, body aches, cough, sore throat, runny or stuffy nose, sneezing, or sinus pressure caused by the flu or common cold.

Mucinex Nightshift Cold and Flu Clear and Cool may also be used for reasons not mentioned in this medication guide.

Use exactly as directed on the label, or as prescribed by your doctor. An acetaminophen overdose can harm your liver or lead to death. Cold or cough medicine is only for short-term use until your symptoms go away.

Always follow the instructions on the medicine label when giving cough or cold medicine to a child. Do not use the medicine just to make a child sleepy. Death can happen from the misuse of cough or cold medicines in very young children.

Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

Call your doctor if you have a sore throat for more than 2 days, especially if you also have a fever, headache, rash, nausea, or vomiting.

If you need surgery or medical tests, inform the surgeon or doctor if you have taken this medicine in the last few days.

Store at room temperature away from moisture and heat. Do not let liquid medicine freeze.

Do not use this medicine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.

An acetaminophen overdose can damage your liver or cause death. Call your doctor at once if you have stomach pain (upper right side), loss of appetite, tiredness, itching, dark urine, clay-colored stools, or yellowing of your skin or eyes.

Stop taking this medicine and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling.

Do not use this medicine only to make a child sleepy.

Do not use this medicine if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

You should not use this medicine if you are allergic to acetaminophen, dextromethorphan, phenylephrine, or triprolidine.

Ask a doctor or pharmacist if this medicine is safe to use if you have:

• liver disease, cirrhosis, alcoholism, or more than 3 alcoholic beverages per day;
• heart problems, high blood pressure;
• diabetes;
• glaucoma;
• a condition for which you take warfarin (Coumadin, Jantoven);
• an enlarged prostate or urination problems;
• a thyroid disorder;
• breathing problems; or
• cough with mucus, or cough caused by smoking, asthma, or emphysema.

Ask a doctor before using this medicine if you are pregnant or breastfeeding.

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

In rare cases, acetaminophen may cause a severe skin reaction that can be fatal. This can happen even if you have taken acetaminophen before without any issues. Stop taking this medicine and call your doctor immediately if you have skin redness or a rash that spreads and causes blistering and peeling. If you have this type of reaction, you should never take any medicine that contains acetaminophen again.

This medicine may cause serious side effects. Stop using this medicine and call your doctor right away if you have:

• any new or worsening symptoms;
• nervousness, dizziness, or drowsiness;
• fever lasting more than 3 days;
• redness, swelling, or rash;
• a headache that won’t go away; or
• pain, cough, or sinus congestion lasting more than 7 days.

Some side effects may be more likely to occur in older adults.

Common side effects of Mucinex Nightshift Cold and Flu Clear and Cool may include:

• dizziness, drowsiness;
• dry mouth, nose, or throat;
• blurred vision;
• constipation;
• feeling restless or excited (especially in children); or
• sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Since Mucinex Nightshift Cold and Flu Clear and Cool is taken as needed, you might not follow a set dosing schedule. If you miss a dose and it's nearly time for your next dose, just skip the missed dose. Do not take two doses at the same time.

Seek emergency medical help or call the Poison Help line at 1-800-222-1222. Taking too much acetaminophen can harm your liver or cause death.

Early signs of acetaminophen overdose include loss of appetite, nausea, vomiting, sweating, or weakness. Later signs may include upper stomach pain, dark urine, and yellowing of your skin or eyes.

Avoid drinking alcohol. It may raise your risk of liver damage.

Do not drive or engage in dangerous activities until you know how this medicine will affect you. Your reactions may be affected.

Ask a doctor or pharmacist before using any other medicine that may contain acetaminophen (sometimes shortened to APAP). Taking too much acetaminophen can result in a fatal overdose.

Avoid using this medicine with other drugs that make you drowsy or slow your breathing (like opioid medicine, a muscle relaxer, or medicine for anxiety or seizures). Ask a doctor or pharmacist before using any other medication, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are included in this medication guide.