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Mucinex Nightshift Sinus

Generic name: acetaminophen, dextromethorphan, phenylephrine, and triprolidine

Brand names: Mucinex Children's FreeFrom Multi-Symptom Cold and Flu Night, Mucinex Nightshift Cold and Flu Clear and Cool, Mucinex Nightshift Sinus, Mucinex Nightshift Sinus Clear and Cool

Last updated November 2, 2026 0 views
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What is Mucinex Nightshift Sinus?

Acetaminophen is a pain reliever and fever reducer. Dextromethorphan is a cough suppressant. Phenylephrine is a decongestant. Triprolidine is an antihistamine.

Mucinex Nightshift Sinus is a combination medicine used to treat headache, fever, body aches, cough, sore throat, runny or stuffy nose, sneezing, or sinus pressure caused by the flu or common cold.

Mucinex Nightshift Sinus may also be used for reasons not mentioned in this medication guide.

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How should I use Mucinex Nightshift Sinus?

Use exactly as directed on the label, or as prescribed by your doctor. An acetaminophen overdose can damage your liver or cause death. Cold or cough medicine is only for short-term use until your symptoms clear up.

Always follow directions on the medicine label about giving cough or cold medicine to a child. Do not use the medicine only to make a child sleepy. Death can occur from the misuse of cough or cold medicines in very young children.

Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

Call your doctor if you have a sore throat for more than 2 days, especially if you also have fever, headache, rash, nausea, or vomiting.

If you need surgery or medical tests, tell the surgeon or doctor if you have taken this medicine within the past few days.

Store at room temperature away from moisture and heat. Do not allow liquid medicine to freeze.

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Warnings

Do not use this medicine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.

An acetaminophen overdose can damage your liver or cause death. Call your doctor at once if you have stomach pain (upper right side), loss of appetite, tiredness, itching, dark urine, clay-colored stools, or yellowing of your skin or eyes.

Stop taking this medicine and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling.

Do not use this medicine only to make a child sleepy.

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Before taking this medicine

Do not use this medicine if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

You should not use this medicine if you are allergic to acetaminophen, dextromethorphan, phenylephrine, or triprolidine.

Ask a doctor or pharmacist if this medicine is safe to use if you have:

  • liver disease, cirrhosis, alcoholism, or more than 3 alcoholic beverages per day;
  • heart problems, high blood pressure;
  • diabetes;
  • glaucoma;
  • a condition for which you take warfarin (Coumadin, Jantoven);
  • an enlarged prostate or urination problems;
  • a thyroid disorder;
  • breathing problems; or
  • cough with mucus, or cough caused by smoking, asthma, or emphysema.

Ask a doctor before using this medicine if you are pregnant or breastfeeding.

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Mucinex Nightshift Sinus side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

In rare cases, acetaminophen may cause a severe skin reaction that can be fatal. This could happen even if you have taken acetaminophen before without any issues. Stop taking this medicine and call your doctor immediately if you have skin redness or a rash that spreads and causes blistering and peeling. If you have this type of reaction, you should never take any medicine that contains acetaminophen again.

This medicine may cause serious side effects. Stop using this medicine and call your doctor right away if you have:

  • any new or worsening symptoms;
  • nervousness, dizziness, or drowsiness;
  • fever lasting more than 3 days;
  • redness, swelling, or rash;
  • ongoing headache; or
  • pain, cough, or sinus congestion lasting more than 7 days.

Some side effects may be more common in older adults.

Common side effects of Mucinex Nightshift Sinus may include:

  • dizziness, drowsiness;
  • dry mouth, nose, or throat;
  • blurred vision;
  • constipation;
  • feeling restless or excited (especially in children); or
  • sleep problems (insomnia).

This is not a complete list of side effects, and others may occur. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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What happens if I miss a dose?

Since Mucinex Nightshift Sinus is taken as needed, you may not have a regular dosing schedule. If you miss a dose and it's nearly time for your next dose, just skip the missed dose. Do not take two doses at the same time.

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What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of acetaminophen can damage your liver or cause death.

Early signs of acetaminophen overdose include loss of appetite, nausea, vomiting, sweating, or weakness. Later symptoms may include upper stomach pain, dark urine, and yellowing of your skin or eyes.

Avoid drinking alcohol. It may increase your risk of liver damage.

Avoid driving or doing hazardous activities until you know how this medicine will affect you. Your reactions could be impaired.

Ask a doctor or pharmacist before using any other medicine that may contain acetaminophen (sometimes abbreviated as APAP). Taking too much acetaminophen can lead to a fatal overdose.

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What other drugs will affect Mucinex Nightshift Sinus?

Avoid using this medicine with other drugs that make you sleepy or slow your breathing (such as opioid medicine, a muscle relaxer, or medicine for anxiety or seizures). Ask a doctor or pharmacist before using any other medication, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are included in this medication guide.

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Before you take this medicine: the information on this page is general and may not cover your personal circumstances. Read the label supplied with your medicine and ask a pharmacist or doctor if you are unsure, especially if you are pregnant, breastfeeding, taking other medicines or managing a long-term condition.
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Content is provided for education and is not medical advice. See our medical disclaimer.