Mucinex Nightshift Sinus Clear and Cool

Acetaminophen is a pain reliever and helps reduce fever. Dextromethorphan is used to suppress coughing. Phenylephrine works as a decongestant. Triprolidine is an antihistamine.

Mucinex Nightshift Sinus Clear and Cool is a combination medicine that treats headache, fever, body aches, cough, sore throat, runny or stuffy nose, sneezing, or sinus pressure caused by the flu or common cold.

Mucinex Nightshift Sinus Clear and Cool may also be used for other purposes not mentioned in this medication guide.

Use exactly as directed on the label, or as prescribed by your doctor. An acetaminophen overdose can harm your liver or cause death. Cold or cough medicine is only for short-term use until your symptoms improve.

Always follow the instructions on the medicine label when giving cough or cold medicine to a child. Do not use the medicine just to make a child sleepy. Misusing cough or cold medicines in very young children can lead to death.

Measure liquid medicine carefully. Use the dosing syringe provided, or a medicine dose-measuring device (not a kitchen spoon).

Call your doctor if you have a sore throat for more than 2 days, especially if you also have fever, headache, rash, nausea, or vomiting.

If you need surgery or medical tests, inform the surgeon or doctor if you have taken this medicine in the past few days.

Store at room temperature away from moisture and heat. Do not let liquid medicine freeze.

Do not use this medicine if you have taken an MAO inhibitor in the last 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.

An acetaminophen overdose can harm your liver or lead to death. Call your doctor immediately if you experience upper right stomach pain, loss of appetite, extreme tiredness, itching, dark urine, clay-colored stools, or yellowing of your skin or eyes.

Stop taking this medicine and call your doctor right away if you notice skin redness or a rash that spreads and causes blistering and peeling.

Do not use this medicine just to make a child sleepy.

Do not use this medicine if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

You should not use this medicine if you are allergic to acetaminophen, dextromethorphan, phenylephrine, or triprolidine.

Ask a doctor or pharmacist if this medicine is safe to use if you have:

• liver disease, cirrhosis, alcoholism, or more than 3 alcoholic beverages per day;
• heart problems, high blood pressure;
• diabetes;
• glaucoma;
• a condition for which you take warfarin (Coumadin, Jantoven);
• an enlarged prostate or urination problems;
• a thyroid disorder;
• breathing problems; or
• cough with mucus, or cough caused by smoking, asthma, or emphysema.

Ask a doctor before using this medicine if you are pregnant or breastfeeding.

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

In rare cases, acetaminophen may cause a severe skin reaction that can be fatal. This could happen even if you have taken acetaminophen before and had no reaction. Stop taking this medicine and call your doctor right away if you notice skin redness or a rash that spreads and causes blistering and peeling. If you have this type of reaction, you should never take any medicine that contains acetaminophen again.

This medicine may cause serious side effects. Stop using this medicine and call your doctor immediately if you have:

• any new or worsening symptoms;
• nervousness, dizziness, or drowsiness;
• a fever lasting more than 3 days;
• redness, swelling, or rash;
• a persistent headache; or
• pain, cough, or sinus congestion lasting more than 7 days.

Some side effects may be more likely in older adults.

Common side effects of Mucinex Nightshift Sinus Clear and Cool may include:

• dizziness, drowsiness;
• dry mouth, nose, or throat;
• blurred vision;
• constipation;
• feeling restless or excited (especially in children); or
• sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Since Mucinex Nightshift Sinus Clear and Cool is taken as needed, you may not have a regular dosing schedule. If you miss a dose and it's almost time for your next dose, skip the missed dose. Do not take two doses at the same time.

Seek emergency medical help or call the Poison Help line at 1-800-222-1222. Taking too much acetaminophen can harm your liver or cause death.

Early signs of an acetaminophen overdose include loss of appetite, nausea, vomiting, sweating, or weakness. Later symptoms may include pain in the upper stomach, dark urine, and yellowing of your skin or eyes.

Do not drink alcohol. It may raise your risk of liver damage.

Do not drive or engage in hazardous activities until you know how this medicine affects you. Your reactions could be affected.

Ask a doctor or pharmacist before using any other medicine that may contain acetaminophen (sometimes called APAP). Taking too much acetaminophen can result in a fatal overdose.

Avoid using this medicine with other drugs that make you sleepy or slow your breathing (like opioid medicine, a muscle relaxer, or medicine for anxiety or seizures). Check with a doctor or pharmacist before using any other medication, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are included in this medication guide.