Multihance

Multihance is a contrast agent that has magnetic properties. It is used with magnetic resonance imaging (MRI) or magnetic resonance angiography (MRA) to help make blood vessels, organs, and other non-bony tissues clearer on MRI or MRA.

Multihance is used to help diagnose certain disorders of the brain and spine (central nervous system).

Multihance is also used in adults to diagnose atherosclerosis (clogged arteries).

Multihance may also be used for purposes not listed in this medication guide.

Multihance can lead to a serious condition in individuals with advanced kidney disease. Before getting this medicine, inform your doctor if you have kidney disease or if you are on dialysis. You may not be able to receive this medicine. Also, let your doctor know if you have recently received any contrast agents similar to this medicine.

Multihance can lead to a serious condition in people with advanced kidney disease. Discuss your personal risk with your doctor.

Multihance can remain in your body for months or years after you get it. It is unclear if this could cause health issues in people with normally functioning kidneys. Inform your doctor if you have had multiple scans with a contrast agent, and give the date of your last scan.

You should not receive Multihance if you are allergic to it.

Inform your doctor if you have ever experienced:

• Dubin Johnson syndrome;
• any kind of reaction to a contrast agent;
• diabetes;
• asthma, hay fever, food or drug allergies;
• heart rhythm disorder, high blood pressure; or
• liver or kidney disease.

Let your doctor know if you are pregnant or breastfeeding.

Get emergency medical help if you have signs of an allergic reaction: hives, difficulty breathing, swelling of your face, lips, tongue, or throat.

Some side effects of gadobenate dimeglumine may occur up to several days after the injection.

Multihance can cause a life-threatening condition in people with advanced kidney disease. Call your doctor right away if you have any symptoms of this condition, such as:

• burning, itching, swelling, scaling, and tightening or hardening of your skin;
• skin redness or discoloration;
• muscle weakness;
• joint stiffness in your arms, hands, legs, or feet;
• pain; or
• tiredness, trouble moving.

Multihance may cause serious side effects. Call your doctor at once if you have:

• kidney problems--little or no urinating; painful or difficult urination; swelling in your feet or ankles; feeling tired or short of breath;
• a seizure (convulsions);
• pounding heartbeats or fluttering in your chest; or
• pain, burning, swelling, blistering, or skin changes where the injection was given.

Common side effects of Multihance may include:

• headache;
• feeling hot;
• nausea; or
• burning around the IV needle.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Multihance is given as an infusion into a vein. A healthcare provider will give you this injection.

You will be watched for a short time to make sure you do not have an allergic reaction.

In a medical setting, it is unlikely that you will miss a dose.

In a medical setting, an overdose will be treated quickly.

Follow your doctor's instructions regarding any restrictions on food, drinks, or activities.

Tell your doctor about all your other medicines, especially:

• cisplatin;
• daunorubicin, doxorubicin;
• etoposide;
• methotrexate;
• paclitaxel;
• tamoxifen; or
• vinblastine, vincristine.

This list is not complete. Other drugs may affect Multihance, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.