Mvasi

Mvasi is used in adults by itself or with other cancer treatments to treat a specific type of brain tumor and certain kinds of cancers of the kidney, liver, lung, colon, rectum, cervix, ovary, or fallopian tube.

Mvasi is also used to treat cancer of the lining of the internal organs in your abdomen. It is typically given as part of a combination of cancer medicines.

Mvasi may also be used for reasons not mentioned in this medication guide.

Mvasi can make it easier for you to bleed. Seek emergency medical attention if you have any bleeding that will not stop. Bleeding may also happen inside your body.

You may not be able to use Mvasi if you are being treated with other cancer medicines such as doxorubicin, daunorubicin, or if you have or have ever had:

• ovarian cancer with symptoms such as severe stomach pain or pelvic pain;
• slow healing of a skin wound or surgical incision;
• surgery within the past 4 weeks (28 days);
• you plan to have surgery within the next 4 weeks (28 days); or
• coughing up blood or vomit that looks like coffee grounds.

Tell your doctor if you have ever had:

• diabetes;
• heart problems such as a heart attack, stroke, blood clot, or blood clotting disorder;
• high blood pressure;
• bleeding problems or a perforation (a hole or tear) in your esophagus, stomach, or intestines; or
• kidney disease.

May harm an unborn baby. Do not use if you are pregnant. You may need a pregnancy test to make sure you are not pregnant. Use effective birth control while using Mvasi and for at least 6 months after your last dose. Tell your doctor at once if you become pregnant.

Mvasi may cause a woman's ovaries to stop working correctly. Symptoms of ovarian failure include 3 or more missed menstrual periods in a row. It may be harder for you to get pregnant while you are using Mvasi and after this treatment. Talk to your doctor about your individual risk.

Do not breastfeed while using this medicine and for at least 6 months after your last dose.

Get emergency medical help if you have signs of an allergic reaction: hives, difficulty breathing, swelling of your face, lips, tongue, or throat.

Some side effects may happen during the injection. Tell your medical caregiver right away if you feel dizzy, nauseous, light-headed, itchy, sweaty, or have a headache, chest tightness, back pain, trouble breathing, or swelling in your face.

Mvasi can cause a serious but rare neurological disorder that affects the brain. Symptoms may happen within hours of your first dose or may not show up for up to a year after your treatment started. Call your doctor right away if you have: extreme weakness or tiredness, headache, confusion, vision problems, fainting, or seizures (blackout or convulsions).

Mvasi can make you bleed more easily. Call your doctor or seek emergency medical help if you have:

• easy bruising, unusual bleeding, or any bleeding that will not stop;
• signs of bleeding in your digestive tract—severe stomach pain, bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds; or
• signs of bleeding in the brain—sudden numbness or weakness, slurred speech, severe headache, problems with vision or balance.

Some people taking Mvasi have developed a perforation (a hole or tear) or a fistula (an abnormal passageway) in the stomach, intestines, throat, lungs, gallbladder, kidney, bladder, or vagina. Call your doctor if you have severe stomach pain or if you feel like you are choking when you eat or drink.

Also call your doctor if you have:

• slow wound healing;
• skin infection or open sores;
• missed menstrual periods;
• kidney problems—swelling, urinating less, feeling tired or short of breath;
• signs of a blood clot—chest pain, sudden cough or shortness of breath, dizziness, coughing up blood, pain, swelling, or warmth in one leg;
• heart problems—chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating, swelling, rapid weight gain, feeling short of breath; or
• low white blood cell counts—fever, mouth sores, skin sores, sore throat, cough.

Your cancer treatments may be delayed or stopped permanently if you have certain side effects.

Common side effects of Mvasi may include:

• increased blood pressure;
• headache, back pain;
• dry or watery eyes;
• dry or flaky skin;
• stuffy nose, runny nose, sneezing; or
• altered sense of taste.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Mvasi is given as an infusion into a vein. A healthcare provider will give you this injection.

Tell your caregivers right away if you feel dizzy, nauseated, light-headed, sweaty, or have a headache, shortness of breath, or chest pain during the injection.

Mvasi is usually given once every 2 or 3 weeks.

Doses are based on weight. Your dose may change if you gain or lose weight.

You may need frequent medical tests and your cancer treatments may be delayed based on the results.

Call your doctor for instructions if you miss an appointment for your Mvasi.

In a medical setting, an overdose would be treated quickly.

• Avoid activities that may increase your risk of bleeding or injury.
• Use extra care while shaving or brushing your teeth.

Tell your doctor about all other cancer treatments you are receiving.

Other medications may influence how Mvasi works, including prescription and over-the-counter drugs, vitamins, and herbal supplements. Inform your doctor about all other medications you take.

Biosimilar and interchangeable products are biological products that are very similar to and have no important differences from the reference product.

Reference products

These are biological products that have already been approved by the FDA and are used as a comparison for biosimilar products. There are 2 for Mvasi.

Avastin (bevacizumab) - Genentech, Inc.

View Avastin information in detail.

Lytenava (bevacizumab-vikg) - Outlook Therapeutics, Inc.

View Lytenava information in detail.

Avastin biosimilar products

Biosimilar products can only be given instead of the reference product if the healthcare provider specifically prescribes the biosimilar product by name.

Pharmacy laws for biosimilar prescribing may vary by state.

Alymsys (bevacizumab-maly) - Amneal Pharmaceuticals LLC

View Alymsys information in detail.

Avzivi (bevacizumab-tnjn) - Bio-Thera Solutions, Ltd.

View Avzivi information in detail.

Jobevne (bevacizumab-nwgd) - Biocon Biologics Inc.

View Jobevne information in detail.

Mvasi (bevacizumab-awwb) - Amgen Inc.

Vegzelma (bevacizumab-adcd) - CELLTRION, Inc.

View Vegzelma information in detail.

Zirabev (bevacizumab-bvzr) - Pfizer Inc.

View Zirabev information in detail.