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Ophthalmic antihistamines and decongestants ophthalmic solution (0.025%-0.3%; 0.027%-0.315%)

Naphazoline and pheniramine ophthalmic

Generic name: naphazoline and pheniramine ophthalmic

Brand names: Naphcon-A, Opcon-A, Visine-A, AK-Con-A, Ocuhist, Visine Allergy Eye Relief

Used for eye redness itching
Last updated November 3, 2026 0 views
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What is naphazoline and pheniramine ophthalmic?

Naphazoline is a medicine that narrows swollen blood vessels in the eyes to help reduce eye redness.

Pheniramine is a medicine that helps lessen the effects of histamine, a natural chemical in the body that can cause itchy or watery eyes.

Naphazoline and pheniramine ophthalmic (for the eyes) is used for temporary relief of minor eye redness or itching caused by ragweed, pollen, grass, or animal dander and hair.

Naphazoline and pheniramine ophthalmic may also be used for other reasons not mentioned in this medication guide.

This section was rewritten for readability and reviewed for meaning.

How should I use naphazoline and pheniramine ophthalmic?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Using the medicine too long or too often may worsen your symptoms and cause damage to blood vessels in your eyes.

Wash your hands before using the eye drops.

To apply the eye drops:

  • Tilt your head back slightly and pull down your lower eyelid to create a small pocket. Hold the dropper above the eye with the tip down. Look up and away from the dropper and squeeze out a drop.
  • Close your eye and gently press your finger to the inside corner of the eye for about 1 minute, to keep the liquid from draining into your tear duct.
  • Use only the number of drops recommended.

Do not touch the tip of the eye dropper or place it directly on your eye. A contaminated dropper can infect your eye, which could lead to serious vision problems.

Do not use the eye drops if the liquid has changed colors or has particles in it. Call your pharmacist for new medicine.

Stop using this medicine and call your doctor if your symptoms do not improve after 3 days of treatment.

Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.

Throw away the eye drops after the expiration date on the medicine label has passed.

This section was rewritten for readability and reviewed for meaning.

Warnings

Follow all instructions on your medicine label and package. Inform all of your healthcare providers about your medical conditions, allergies, and all medications you are taking.

This section was rewritten for readability and reviewed for meaning.

Before taking this medicine

You should not use naphazoline and pheniramine ophthalmic if you are allergic to naphazoline or pheniramine.

Ask a doctor or pharmacist if it is safe for you to take this medicine if you have other medical conditions, especially:

  • heart disease, high blood pressure;
  • urination problems; or
  • narrow-angle glaucoma.

It is not known whether naphazoline and pheniramine ophthalmic will harm an unborn baby. Do not use this medicine without a doctor's advice if you are pregnant.

It is not known whether naphazoline and pheniramine ophthalmic passes into breast milk or if it could harm a nursing baby. Do not use this medicine without a doctor's advice if you are breast-feeding a baby.

Naphazoline and pheniramine ophthalmic should not be given to a child younger than 6 years old without a doctor's advice.

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Naphazoline and pheniramine ophthalmic side effects

Get emergency medical help if you notice signs of an allergic reaction: hives; trouble breathing; swelling of your face, lips, tongue, or throat.

naphazoline and pheniramine ophthalmic can cause serious side effects. Stop using naphazoline and pheniramine ophthalmic and call your doctor right away if you experience:

  • ongoing or worsening eye redness;
  • eye pain; or
  • changes in your vision.

Common side effects of naphazoline and pheniramine ophthalmic may include:

  • mild burning or stinging in the eye;
  • dilated pupils, blurred vision; or
  • increased sensitivity to light.

This is not a complete list of side effects and others may happen. Call your doctor for medical advice about side effects. You can report side effects to FDA at 1-800-FDA-1088.

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What happens if I miss a dose?

Since naphazoline and pheniramine ophthalmic is used as needed, you might not have a dosing schedule. If you do have a schedule and miss a dose, take it as soon as you remember. If it's nearly time for your next dose, skip the missed dose. Do not use extra medicine to make up for the missed dose.

This section was rewritten for readability and reviewed for meaning.

What happens if I overdose?

An overdose of naphazoline and pheniramine ophthalmic is not expected to be dangerous. Seek emergency medical help or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication.

Keep this medicine out of the reach of children. Certain eye medications can cause serious health issues in a young child who accidentally sucks on or swallows medicine from the eye dropper.

Do not use this medication while wearing contact lenses. Naphazoline and pheniramine ophthalmic may have a preservative that can change the color of soft contact lenses. Wait at least 15 minutes after using naphazoline and pheniramine ophthalmic before putting in your contact lenses.

This section was rewritten for readability and reviewed for meaning.

What other drugs will affect naphazoline and pheniramine ophthalmic?

Ask a doctor or pharmacist before using this medicine if you are taking any other drugs, including prescription and over-the-counter medicines, vitamins, and herbal products. Some medicines can cause unwanted or harmful effects when used together. Not all possible interactions are included in this medication guide.

This section was rewritten for readability and reviewed for meaning.

Related medicines

Before you take this medicine: the information on this page is general and may not cover your personal circumstances. Read the label supplied with your medicine and ask a pharmacist or doctor if you are unsure, especially if you are pregnant, breastfeeding, taking other medicines or managing a long-term condition.
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Content is provided for education and is not medical advice. See our medical disclaimer.