NebuSal (inhalation)

NebuSal is the chemical name for salt. This medicine can reduce some types of bacteria in certain body fluids, like saliva.

NebuSal is used to create sputum (mucus, or phlegm) from the mouth to help improve lung function in people with cystic fibrosis, or to collect sputum for medical testing. This medication may also be used to dilute other medications that are inhaled through a nebulizer.

NebuSal may also be used for other reasons not listed in this medication guide.

Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

NebuSal is given using a nebulizer. You will inhale the medication through a face mask, mouthpiece, or other device connected to the nebulizer.

Your doctor, nurse, or other healthcare provider can show you how to properly use the nebulizer.

NebuSal is a liquid that is placed into the medication chamber of the nebulizer. A mouthpiece or face mask is then attached to the drug chamber, along with an air compressor.

To prepare for inhaling NebuSal through a nebulizer, you may be given another inhaled medication to prevent bronchospasm (muscle contractions within the airways of the lungs). Your doctor may also ask you to blow your nose, rinse your mouth with water, or wipe the inside of your mouth with a tissue. Follow your doctor's instructions carefully for best results.

In most cases, you will use this medication while you are sitting upright in a comfortable position. Breathe slowly and evenly while you are using the mask, mouthpiece, or other breathing device. You may also be given a nose clip to wear that will close your nasal passages so that you inhale only through your mouth.

If you are using this medication as part of a sputum test, you will need to spit about every 5 minutes or as directed by your healthcare provider. Cough deeply from your chest to produce an optimal specimen for testing.

Continue breathing through the nebulizer for as long as directed by your doctor. Once you have completed the inhalation for the prescribed amount of time, throw away any liquid that is left in the medicine chamber. Do not save it for later use.

If you store NebuSal at home, keep it at room temperature away from moisture and heat.

Before using NebuSal, inform your doctor about all your medical conditions and allergies. Also, make sure your doctor is aware if you are pregnant or breastfeeding. In some situations, you may not be able to use this medicine, or your dose may need to be adjusted, or you may need to take special precautions.

Inform your doctor about all other medications you are taking, particularly potassium supplements, diuretics, steroids, blood pressure medications, or medications that contain sodium (like Alka-Seltzer or Zegrid).

Notify your caregiver immediately if you experience chest pain, difficulty breathing, swelling in your hands or feet, fatigue, muscle twitching, confusion, irregular heart rate, extreme thirst, changes in urination, leg discomfort, muscle weakness or feeling faint, or if you feel like you might faint.

You should not use this medication if you have ever had an allergic reaction to NebuSal.

To make sure NebuSal is safe for you, tell your doctor if you have:

• asthma;
• heart disease or high blood pressure;
• epilepsy;
• kidney or liver disease;
• migraine headaches;
• any type of edema (swelling);
• if you have recently had surgery; or
• if you are on a low-salt diet.

FDA pregnancy category C. It is not known whether NebuSal is harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether sodium chloride passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your caregiver right away if you have:

• chest pain, trouble breathing;
• a light-headed feeling, like you might pass out;
• swelling in your hands or feet;
• tiredness, muscle twitching;
• confusion, uneven heart rate, extreme thirst, increased or decreased urination, leg discomfort, muscle weakness or limp feeling.

Other common side effects may include a salty taste or slight burning or irritation in your mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Since NebuSal is sometimes used only when needed, you might not have a specific dosing schedule. If you are using the medication regularly, take the missed dose as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose. Do not use extra medicine to compensate for the missed dose.

Seek emergency medical help or call the Poison Help line at 1-800-222-1222.

Follow your doctor’s instructions regarding any limitations on food, drinks, or activities.

Tell your doctor about all the medicines you are using, as well as any that you start or stop while being treated with NebuSal, especially:

• potassium supplements;
• a diuretic or "water pill";
• a steroid such as prednisone, fluticasone, mometasone, dexamethasone, and others;
• blood pressure medication; or
• medication that contains sodium, such as Alka-Seltzer or Zegrid (omeprazole and sodium bicarbonate).

This list is not complete. Other drugs may interact with sodium chloride, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are included in this medication guide.