Neo-Fradin (Oral)

Oral neomycin is used to reduce the symptoms of hepatic coma, which is a complication of liver disease. It may also be used with another medicine before surgery that affects the bowels to help prevent infection during the procedure.

Neomycin is available only with your doctor's prescription.

In deciding to use a medicine, you need to consider the risks of taking it against the benefits it may provide. This is a decision you will make with your doctor. For this medicine, please think about the following:

Allergies

Inform your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also, let your healthcare professional know if you have any other allergies, including to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Premature infants and neonates are more sensitive to the effects of neomycin, which makes them more likely to experience damage to hearing, sense of balance, and kidneys.

Geriatric

Elderly patients are often more sensitive than younger adults to the effects of neomycin, which can lead to serious side effects like damage to hearing, sense of balance, and kidneys.

Breast Feeding

There are no adequate studies in women to determine the risk to infants when using this medication during breastfeeding. Consider the potential benefits against the potential risks before using this medication while breastfeeding.

Interactions with Medicines

Some medicines should not be used together at all, while in some cases, two different medicines may be used together despite potential interactions. In these situations, your doctor may adjust the dose or take other precautions. When taking this medicine, it is especially important to inform your healthcare professional if you are using any of the following medicines. The following interactions have been chosen based on their potential importance and are not necessarily a complete list.

Using this medicine with any of the following medicines is usually not recommended but may be necessary in some cases. If both medicines are prescribed together, your doctor may change the dose or the frequency of one or both medicines.

• Alcuronium
• Aspirin
• Atracurium
• Cidofovir
• Cisatracurium
• Colistimethate Sodium
• Decamethonium
• Doxacurium
• Emtricitabine
• Ethacrynic Acid
• Fazadinium
• Foscarnet
• Furosemide
• Gallamine
• Hexafluorenium
• Methotrexate
• Metocurine
• Mivacurium
• Pancuronium
• Pipecuronium
• Rapacuronium
• Rocuronium
• Sorafenib
• Tacrolimus
• Tenofovir Alafenamide
• Tubocurarine
• Vecuronium

Using this medicine with any of the following medicines may raise the risk of certain side effects, but using both drugs may be the best option for you. If both medicines are prescribed together, your doctor may adjust the dose or frequency for one or both.

• Bumetanide
• Digoxin
• Semaglutide

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be taken at or around mealtime or with specific types of food because interactions may happen. Using alcohol or tobacco with some medicines might also lead to interactions. Talk to your healthcare professional about using your medicine with food, alcohol, or tobacco.

Other Medical Problems

Other medical issues may affect how you can use this medicine. Make sure to inform your doctor if you have any other medical problems, especially:

• Blockage of the bowel

• Eighth-cranial-nerve disease (loss of hearing and/or balance)—Oral neomycin may increase the risk of hearing loss and/or balance issues

• Kidney disease—Patients with kidney disease might have a higher chance of side effects

• Myasthenia gravis or
• Parkinson's disease—Patients with these conditions may have an increased risk of developing muscle weakness

• Ulcers of the bowel—Patients with bowel ulcers may have a higher chance of side effects since more neomycin may be absorbed by the body

Along with its necessary effects, a medicine may cause some unwanted effects. Not all of these side effects may happen, but if they do, they may need medical attention.

Check with your doctor right away if any of the following side effects happen:

Rare

• Any loss of hearing
• clumsiness
• diarrhea
• difficulty in breathing
• dizziness
• drowsiness
• greatly decreased frequency of urination or amount of urine
• increased amount of gas
• increased thirst
• light-colored, frothy, fatty-appearing stools
• ringing or buzzing or a feeling of fullness in the ears
• skin rash
• unsteadiness
• weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue, are bothersome, or if you have any questions about them:

More common

• Irritation or soreness of the mouth or rectal area
• nausea or vomiting

Other side effects not listed may also happen in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

In the U.S.

• Neo-Fradin

Available Dosage Forms:

• Tablet
• Solution

Therapeutic Class: Antibiotic

Chemical Class: Aminoglycoside

This medicine may be taken on a full or empty stomach.

For patients taking the oral liquid form of neomycin:

• Use a specially marked measuring spoon or other device to measure each dose accurately. The average household teaspoon may not hold the right amount of liquid.

Keep taking this medicine for the full time of treatment. Do not miss any doses.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage forms (solution, tablets): For patients in a coma from liver disease: Adults and teenagers—1 to 3 grams every six hours for five or six days. Children—Dose is based on body size (not weight) and must be determined by your doctor. That dose is given every six hours for five or six days. For cleaning the bowel before surgery: Adults and teenagers—1 gram every hour for four hours, then 1 gram every four hours for the rest of a twenty-four hour period; or 1 gram nineteen hours before surgery, 1 gram eighteen hours before surgery, and 1 gram nine hours before surgery. Children—Dose is based on body weight. The usual dose is 14.7 milligrams (mg) per kilogram (kg) (6.7 mg per pound) of body weight every four hours for three days.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

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