Neomycin, polymyxin b, and hydrocortisone (Ophthalmic)

Neomycin, polymyxin B, and hydrocortisone is a mix of an antibiotic and a cortisone-like medicine. It is used to treat eye infections and to relieve redness, irritation, and discomfort from certain eye issues. It is also used to help prevent lasting damage from certain eye problems.

Neomycin, polymyxin B, and hydrocortisone combination is available only with your doctor's prescription.

If you will be using this medicine for more than 10 days, your doctor should check your eyes at regular visits.

If your symptoms do not improve within a few days, or if they become worse, check with your doctor.

If a rash or allergic reaction develops, you should check with your doctor right away.

You should not let anyone else use your medicine. It could cause infection to spread.

Do not use any leftover medicine for future eye problems without checking with your doctor first. This medicine should not be used on many different kinds of infection.

In deciding to use a medicine, you need to consider the risks of taking it against the benefits it may provide. This decision will be made together with your doctor. For this medicine, you should think about the following:

Allergies

Inform your doctor if you have ever had any unusual or allergic reactions to this medicine or any other medicines. Also let your healthcare professional know if you have any other types of allergies, like to foods, dyes, preservatives, or animals. For non-prescription products, carefully read the label or package ingredients.

Pediatric

Studies on this medicine have only been conducted with adult patients, and there is no specific information comparing its use in children to other age groups.

Geriatric

Many medicines have not been specifically studied in older adults. Therefore, it may not be clear if they work the same way in older people compared to younger adults or if they cause different side effects or issues in older adults. There is no specific information comparing the use of ophthalmic neomycin, polymyxin B, and hydrocortisone combination in older adults with use in other age groups.

Breast Feeding

There are no adequate studies in women to determine the risk to infants when using this medication while breastfeeding. Weigh the potential benefits against the potential risks before using this medication while breastfeeding.

Interactions with Medicines

Some medicines should never be used together, while others can be used together even if an interaction might happen. In these cases, your doctor may adjust the dose or take other precautions. When taking this medicine, it is very important that your healthcare professional knows if you are taking any of the following medicines. The following interactions are selected for their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may choose not to treat you with this medication or change some of the other medicines you take.

• Desmopressin
• Rotavirus Vaccine, Live

Using this medicine with any of the following medicines is usually not recommended, but may be necessary in some cases. If both medicines are prescribed together, your doctor may adjust the dose or how often you use one or both of the medicines.

• Abametapir
• Aceclofenac
• Acemetacin
• Alcuronium
• Aldesleukin
• Amtolmetin Guacil
• Aspirin
• Atazanavir
• Atracurium
• Balofloxacin
• Bemiparin
• Besifloxacin
• Bromfenac
• Bufexamac
• Bupropion
• Celecoxib
• Choline Salicylate
• Cidofovir
• Ciprofloxacin
• Cisatracurium
• Clonixin
• Cobicistat
• Colistimethate Sodium
• Conivaptan
• Darunavir
• Decamethonium
• Dexibuprofen
• Dexketoprofen
• Diclofenac
• Diflunisal
• Dipyrone
• Doxacurium
• Droxicam
• Emtricitabine
• Enoxacin
• Ethacrynic Acid
• Etodolac
• Etofenamate
• Etoricoxib
• Fazadinium
• Fedratinib
• Felbinac
• Fenoprofen
• Fepradinol
• Feprazone
• Fexinidazole
• Fleroxacin
• Floctafenine
• Flufenamic Acid
• Flumequine
• Flurbiprofen
• Foscarnet
• Fosnetupitant
• Furosemide
• Gallamine
• Gatifloxacin
• Gemifloxacin
• Hexafluorenium
• Ibuprofen
• Indomethacin
• Itraconazole
• Ketoprofen
• Ketorolac
• Lenacapavir
• Levofloxacin
• Lomefloxacin
• Lornoxicam
• Loxoprofen
• Lumiracoxib
• Lutetium Lu 177 Dotatate
• Macimorelin
• Mavacamten
• Meclofenamate
• Mefenamic Acid
• Meloxicam
• Metocurine
• Mivacurium
• Morniflumate
• Moxifloxacin
• Nabumetone
• Nadifloxacin
• Nadroparin
• Naproxen
• Nepafenac
• Netupitant
• Niflumic Acid
• Nimesulide
• Nimesulide Beta Cyclodextrin
• Norfloxacin
• Ofloxacin
• Omaveloxolone
• Oxaprozin
• Oxyphenbutazone
• Pancuronium
• Parecoxib
• Pazufloxacin
• Pefloxacin
• Phenobarbital
• Phenylbutazone
• Piketoprofen
• Pipecuronium
• Piroxicam
• Pranoprofen
• Primidone
• Proglumetacin
• Propyphenazone
• Proquazone
• Prulifloxacin
• Rapacuronium
• Rocuronium
• Rofecoxib
• Rufloxacin
• Salicylic Acid
• Salsalate
• Sargramostim
• Sodium Salicylate
• Somatrogon-ghla
• Sorafenib
• Sparfloxacin
• Sulindac
• Tacrolimus
• Tenofovir Alafenamide
• Tenoxicam
• Tiaprofenic Acid
• Tolfenamic Acid
• Tolmetin
• Tosufloxacin
• Tubocurarine
• Valdecoxib
• Vecuronium

Using this medicine with any of the following medicines may increase the risk of certain side effects, but using both drugs may be the best option for you. If both medicines are prescribed together, your doctor may adjust the dose or how often you use one or both of the medicines.

• Alcuronium
• Atracurium
• Auranofin
• Bumetanide
• Colestipol
• Gallamine
• Hexafluorenium
• Licorice
• Metocurine
• Rifapentine
• Saiboku-To

Interactions with Food/Tobacco/Alcohol

Some medicines should not be taken around mealtime or with certain foods because interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions. Talk to your healthcare professional about using your medicine with food, alcohol, or tobacco.

Other Medical Problems

Having other medical problems may affect how you can use this medicine. Make sure to inform your doctor if you have any other medical issues, especially:

• Any other eye infection or condition or
• Glaucoma—Using neomycin, polymyxin B, and hydrocortisone ophthalmic drops may worsen this condition.

• Recent cataract surgery—Using neomycin, polymyxin B, and hydrocortisone ophthalmic drops may delay healing or cause other issues.

Along with its needed effects, this medicine may cause some unwanted effects. Not all of these side effects may occur, but if they do, they may need medical attention.

Stop taking this medicine and get emergency help immediately if any of the following effects occur:

Rare

• Fainting
• Lightheadedness (sudden and severe)
• Shortness of breath or trouble breathing (severe)
• Swelling around the face

Check with your doctor immediately if any of the following side effects occur:

More common

• Itching, rash, redness, swelling, or other signs of irritation that were not present before using this medicine

Rare

• Blurred vision or other changes in vision
• Delayed healing of eye infection

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Your health care professional may also be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue, are bothersome, or if you have any questions about them:

Less common

• Burning or stinging when applying the medicine

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your health care professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

In the U.S.

• Cortisporin

Available Dosage Forms:

• Suspension

Therapeutic Class: Aminoglycoside/Corticosteroid Combination

Pharmacologic Class: Adrenal Glucocorticoid

Chemical Class: Neomycin

The bottle is only partially full to provide proper drop control.

To use:

• First, wash your hands. Then tilt the head back and pull the lower eyelid away from the eye to form a pouch. Drop the medicine into the pouch and gently close the eyes. Do not blink. Keep the eyes closed for 1 or 2 minutes to allow the medicine to come into contact with the infection.
• If you think you did not get the drop of medicine into your eye properly, use another drop.
• To keep the medicine as germ-free as possible, do not touch the applicator tip to any surface (including the eye). Also, keep the container tightly closed.

To help clear up your infection completely, keep using this medicine for the full time of treatment, even if your symptoms have disappeared. Do not miss any doses.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For eye infection: For ophthalmic suspension dosage forms: Adults—One or two drops every three or four hours. Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.