Neostigmine

Neostigmine is used to reverse the effects of anesthesia medications used during surgery.

Neostigmine may also be used for reasons not mentioned in this medication guide.

You should not be treated with neostigmine if you have a bladder or bowel obstruction, or a serious condition called peritonitis (inflammation of the membrane lining the organs inside your abdomen).

You should not be treated with neostigmine if you are allergic to it, or if you have:

• a bladder obstruction or other urination problems;
• a blockage in your digestive tract (stomach or intestines); or
• a serious disorder called peritonitis (inflammation of the membrane lining the organs inside your abdomen).

Tell your doctor if you have ever had:

• coronary artery disease (clogged arteries);
• a heart rhythm disorder; or
• myasthenia gravis.

Tell your doctor if you are pregnant or breastfeeding.

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers right away if you have muscle weakness as you wake up from surgery.

Common side effects of neostigmine may include:

• nausea, vomiting; or
• slow heartbeats.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Neostigmine is given as an infusion into a vein. A healthcare provider will give you this injection.

Your breathing, blood pressure, oxygen levels, kidney function, and other vital signs will be watched closely.

Your doctor will also test your reflexes to make sure neostigmine is effective in reversing the anesthesia.

Because it is used only when needed for surgery, it does not have a daily dosing schedule.

Since neostigmine is administered by a healthcare professional in a medical setting, it is unlikely that an overdose will happen.

Follow your doctor's instructions regarding any limitations on food, drinks, or activities.

Other drugs may affect neostigmine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you begin or stop using.