Orfro (Injection)

Orphenadrine is used to help relax certain muscles in your body and relieve stiffness, pain, and discomfort caused by strains, sprains, or other muscle injuries. However, this medicine does not replace rest, exercise, physical therapy, or other treatments your doctor may recommend for your medical issue.

Orphenadrine works in the central nervous system (CNS) to provide its muscle relaxant effects.

This medicine is available only with your doctor's prescription.

Your doctor will only provide a limited number of doses of this medicine until your condition gets better, and then you will be changed to an oral medicine that works similarly. If you have any questions about this, speak with your doctor.

In deciding to use a medicine, you and your doctor need to consider the risks of taking the medicine compared to the benefits it may provide. The following factors should be considered for this medicine:

Allergies

The dose of this medicine varies for different patients. Always follow your doctor's instructions or the directions on the label. The information provided includes only the average doses. If your prescribed dose is different, do not change it unless your doctor advises you to do so.

The amount of medicine you take depends on its strength. The number of doses you take each day, the time between doses, and how long you take the medicine depend on the medical issue you are treating.

Pediatric

Studies have not been done to determine how age affects the use of orphenadrine in children. Its safety and effectiveness have not been confirmed for this age group.

Geriatric

There is no information on how age affects the use of orphenadrine in older patients. However, elderly patients are more likely to have heart, liver, or kidney issues related to aging, which may require caution when using orphenadrine.

Breast Feeding

There are not enough studies on women to determine the risk to infants when using this medication during breastfeeding. Consider the possible benefits and risks before taking this medication while breastfeeding.

Interactions with Medicines

Some medicines should not be used together at all, while in other situations, two different medicines may be used together even if an interaction could occur. In these cases, your doctor may need to adjust the dose or take other precautions. It is very important for your healthcare provider to know if you are taking any of the medicines listed below. The following interactions have been chosen based on their potential significance and are not necessarily a complete list.

Using this medicine with any of the following medicines is not recommended. Your doctor may choose not to treat you with this medication or change some of the other medicines you are taking.

• Potassium Citrate

Using this medicine with any of the following medicines is usually not recommended, but may be necessary in some situations. If both medicines are prescribed together, your doctor may change the dose or how often you take one or both of the medicines.

• Alfentanil
• Alprazolam
• Amantadine
• Amifampridine
• Benzhydrocodone
• Bromazepam
• Buprenorphine
• Butorphanol
• Calcium Oxybate
• Cannabidiol
• Cannabis
• Cetirizine
• Clobazam
• Clonazepam
• Clozapine
• Codeine
• Daridorexant
• Dexmedetomidine
• Dihydrocodeine
• Donepezil
• Doxylamine
• Esketamine
• Fentanyl
• Flibanserin
• Gabapentin
• Gabapentin Enacarbil
• Glucagon
• Glycopyrrolate
• Glycopyrronium Tosylate
• Hydrocodone
• Hydromorphone
• Ketamine
• Lacosamide
• Lemborexant
• Levocetirizine
• Levorphanol
• Lofexidine
• Loxapine
• Magnesium Oxybate
• Meperidine
• Methacholine
• Methadone
• Metoclopramide
• Midazolam
• Morphine
• Morphine Sulfate Liposome
• Nalbuphine
• Olanzapine
• Oxycodone
• Oxymorphone
• Pentazocine
• Phenobarbital
• Potassium Oxybate
• Pregabalin
• Primidone
• Quetiapine
• Remifentanil
• Remimazolam
• Revefenacin
• Ropeginterferon Alfa-2b-njft
• Scopolamine
• Secretin Human
• Sodium Oxybate
• Sufentanil
• Tapentadol
• Tiotropium
• Topiramate
• Tramadol
• Trazodone
• Zolpidem
• Zuranolone

Using this medicine with any of the following medicines may increase the risk of certain side effects, but using both medicines may be the best option for your treatment. If both are prescribed together, your doctor may adjust the dose or the frequency of use for one or both medicines.

• Perphenazine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used around the time of eating or with specific types of food due to possible interactions. Using alcohol or tobacco with certain medicines may also lead to interactions. Talk to your healthcare provider about using your medicine with food, alcohol, or tobacco.

Other Medical Problems

Having other medical issues may affect how you use this medicine. Make sure to inform your doctor if you have any other medical conditions, especially:

• Enlarged esophagus or
• Enlarged prostate or
• Glaucoma or
• Intestinal blockage or
• Myasthenia gravis or
• Stomach ulcer or
• Urinary tract blockage—Orphenadrine should not be used in patients with these conditions.

• Heart problems (e.g., fast or irregular heartbeats, heart failure)—Use with caution. Orphenadrine may worsen these conditions.

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Rare

• Cough
• difficulty swallowing
• dizziness
• fast heartbeat
• hives
• itching
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• shortness of breath
• skin rash
• tightness in chest
• unusual tiredness or weakness
• wheezing

Incidence not known

• Abdominal or stomach pain
• diarrhea
• fast, pounding, or irregular heartbeat or pulse
• fever
• glaucoma
• joint or muscle pain
• nausea
• numbness or tingling of face, hands, or feet
• redness and soreness of eyes
• shortness of breath
• sores in mouth
• swelling of feet or lower legs
• vomiting

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of Overdose

• Blurred vision
• confusion, delirium, or hallucinations
• constipation
• difficult urination
• drowsiness
• dry eyes, mouth, nose, or throat
• eye pain
• flushing or redness of face
• troubled breathing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

• Anxiety
• deep or fast breathing with dizziness
• headache
• irritability
• itching skin
• mental confusion
• nervousness
• numbness of feet, hands, and around mouth
• restlessness
• trembling or shaking of hands or feet, shakiness in legs, arms, hands, or feet
• unusually large pupils of eyes
• weakness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

In the U.S.

• Antiflex
• Mio-Rel
• Norflex
• Orfro
• Orphenate

Available Dosage Forms:

• Solution

Therapeutic Class: Skeletal Muscle Relaxant, Centrally Acting

Pharmacologic Class: Antimuscarinic

A nurse or other trained health professional will give you this medicine. This medicine is given through a needle placed in one of your veins or into your muscle.