Oxacillin (injection)

Oxacillin is a type of penicillin antibiotic that helps fight bacterial infections in the body.

Oxacillin is used to treat various infections caused by staphylococcus, which is also known as "staph" infection.

Oxacillin might also be used for other reasons that are not mentioned in this medication guide.

You should not use oxacillin if you are allergic to oxacillin or to any other penicillin antibiotic.

You should not use this medicine if you are allergic to oxacillin or to any other penicillin antibiotic, such as:

• amoxicillin, Augmentin;
• ampicillin;
• carbenicillin;
• dicloxacillin; or
• penicillin.

To ensure that oxacillin is safe for you, inform your doctor if you have:

• asthma;
• kidney disease;
• liver disease; or
• a history of any type of allergy.

Oxacillin injection is not expected to harm an unborn baby. Inform your doctor if you are pregnant.

Oxacillin can make birth control pills less effective. Ask your doctor about using a non-hormonal birth control method (such as a condom or diaphragm with spermicide) to prevent pregnancy.

Oxacillin can pass into breast milk and may harm a nursing baby. Inform your doctor if you are breastfeeding.

Get emergency medical help if you have signs of an allergic reaction: hives, itching; wheezing, difficulty breathing; feeling light-headed; swelling of your face, lips, tongue, or throat.

An allergic reaction to oxacillin can happen right after you use the medicine, or you may experience a delayed reaction.

An immediate allergic reaction can occur within 48 hours after using oxacillin and may cause fever along with an itchy skin rash.

A delayed reaction can happen more than 48 hours and up to 4 weeks after using oxacillin. Symptoms of a delayed reaction may include fever with swollen glands, rash or itching, joint pain, stomach pain, and a general feeling of being unwell.

Call your doctor or seek medical attention if you think you may be having an allergic reaction. Also, call your doctor right away if you have:

• severe stomach pain, diarrhea that is watery or bloody;
• nausea, vomiting;
• bruising or swelling around the IV needle;
• kidney problems—little or no urination, painful or difficult urination, red or pink urine;
• liver problems—nausea, upper stomach pain, itching, tiredness, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
• low white blood cell counts—fever, chills, sore throat, swollen gums, mouth sores, pain when swallowing, skin sores, cold or flu symptoms, cough, trouble breathing.

Common side effects of oxacillin may include:

• nausea, upset stomach, vomiting, mild diarrhea;
• vaginal itching or discharge;
• swollen, black, or "hairy" tongue; or
• thrush (white patches in your mouth or throat).

This is not a complete list of side effects, and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Follow all directions on your prescription label. Do not use oxacillin in larger or smaller amounts or for longer than recommended.

Oxacillin is injected into a vein through an IV. You may be shown how to use an IV at home. Do not give yourself this medicine if you do not understand how to use the injection and properly dispose of needles, IV tubing, and other items used.

You may need to use oxacillin injection for 14 days or longer if your infection is severe. Follow your doctor's dosing instructions carefully.

You may need to keep using oxacillin for up to 48 hours after lab tests show that your infection has cleared.

Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Oxacillin will not treat a viral infection such as the flu or a common cold.

Pay close attention to the expiration date on your medicine label or IV bag. Do not use the medicine if the expiration date has passed. Call your pharmacist for new medicine.

Your doctor may change your medication if your lab (cultures) tests show that your infection is not caused by staphylococcus.

While using oxacillin, you may need frequent blood tests.

Store at room temperature away from moisture, heat, and light.

Use the missed dose as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose. Do not use extra medicine to make up for the missed dose.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Antibiotic medicines can cause diarrhea, which may mean you have a new infection. If you have diarrhea that is watery or bloody, call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

Tell your doctor about all the medicines you are currently taking and any that you start or stop, especially:

• probenecid; or
• tetracycline.

This list does not include everything. Other drugs may interact with oxacillin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are included in this medication guide.