Oxtriphylline and guaifenesin (Oral)

Oxtriphylline and guaifenesin combination is used to treat or prevent symptoms of asthma, as well as to treat chronic bronchitis and emphysema. This medicine helps relieve cough, wheezing, shortness of breath, and difficulty breathing. It works by opening up the bronchial tubes (the air passages in the lungs) and increasing airflow through them.

This medicine is available only with your doctor's prescription.

Your doctor should check how you are doing at regular visits, especially during the first few weeks after you start using this medicine. A blood test may be done to help your doctor determine if the dose of this medicine needs to be adjusted.

The oxtriphylline in this medicine may increase the stimulating effects of caffeine found in foods or drinks like chocolate, cocoa, tea, coffee, and cola. Avoid consuming large amounts of these foods or drinks while taking this medicine. If you have any questions about this, ask your doctor.

Changes in your usual behavior or physical health may influence how this medicine works in your body. Check with your doctor if you:

• have a fever of 102 °F or higher for at least 24 hours or higher than 100 °F for longer than 24 hours.
• start or stop smoking.
• start or stop taking another medicine.
• change your diet for a long time.

Before you undergo myocardial perfusion studies (a medical test that shows how well blood is flowing to your heart), inform the medical doctor in charge that you are taking this medicine. The results of the test may be influenced by this medicine.

In deciding to use a medicine, you and your doctor need to consider the risks of taking the medicine compared to its benefits. The following factors should be considered for this medicine:

Allergies

Inform your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also, let your healthcare professional know about any other allergies you might have, such as to foods, dyes, preservatives, or animals. For over-the-counter products, carefully read the label or package ingredients.

Pediatric

This medicine is not recommended for children because it has high alcohol content.

There is no specific information about the use of guaifenesin in children, but it is not expected to cause different side effects or problems in children than it does in adults.

Geriatric

Patients over 60 years old may need a lower dose than younger adults. If the amount of oxtriphylline is too high, side effects are more likely to happen. Your doctor may want to take blood samples to see if a dose adjustment is necessary.

There is no specific information about the use of guaifenesin in older adults, but it is not expected to cause different side effects or problems in older people than it does in younger adults.

Breast Feeding

There are not enough studies in women to determine the risk to infants when using this medicine while breastfeeding. You should weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Studies suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with Medicines

Some medicines should not be used together, while others may be used together even if there might be an interaction. In these cases, your doctor may adjust the dose or take other precautions. It is especially important that your healthcare professional knows if you are taking any of the medicines listed below. The following interactions have been chosen based on their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to use this medication or change some of the other medicines you take.

• Riociguat
• Viloxazine

Using this medicine with any of the following medicines is usually not recommended, but may be needed in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Abametapir
• Adalimumab
• Adenosine
• Amifampridine
• Bupropion
• Capmatinib
• Ceritinib
• Cimetidine
• Ciprofloxacin
• Deferasirox
• Desogestrel
• Dienogest
• Dihydroartemisinin
• Donepezil
• Drospirenone
• Enoxacin
• Erythromycin
• Estetrol
• Estradiol
• Ethinyl Estradiol
• Ethynodiol
• Etintidine
• Etonogestrel
• Febuxostat
• Fluconazole
• Fluvoxamine
• Fosphenytoin
• Gestodene
• Givosiran
• Halothane
• Idrocilamide
• Imipenem
• Ketamine
• Leniolisib
• Levofloxacin
• Levonorgestrel
• Medroxyprogesterone
• Mestranol
• Methacholine
• Mexiletine
• Nomegestrol
• Norelgestromin
• Norethindrone
• Norgestimate
• Norgestrel
• Paroxetine
• Pefloxacin
• Peginterferon Alfa-2a
• Peginterferon Alfa-2b
• Phenytoin
• Pixantrone
• Regadenoson
• Ritlecitinib
• Rofecoxib
• Segesterone
• Taurursodiol
• Thiabendazole
• Tocilizumab
• Troleandomycin
• Vemurafenib
• Zileuton

Using this medicine with any of the following medicines may increase the risk of certain side effects, but using both drugs may be necessary for your treatment. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Adinazolam
• Alprazolam
• Aminoglutethimide
• Amiodarone
• Azithromycin
• Bentazepam
• Bromazepam
• Brotizolam
• Carbamazepine
• Chlordiazepoxide
• Clobazam
• Clonazepam
• Clorazepate
• Delorazepam
• Diazepam
• Disulfiram
• Estazolam
• Flunitrazepam
• Flurazepam
• Halazepam
• Interferon Alfa-2a
• Ipriflavone
• Isoproterenol
• Ketazolam
• Loprazolam
• Lorazepam
• Lormetazepam
• Medazepam
• Metaclazepam
• Methotrexate
• Midazolam
• Nilutamide
• Nitrazepam
• Oxazepam
• Pancuronium
• Pentoxifylline
• Phenobarbital
• Pinazepam
• Piperine
• Prazepam
• Propafenone
• Quazepam
• Remimazolam
• Rifampin
• Rifapentine
• Ritonavir
• Secobarbital
• Semaglutide
• St John's Wort
• Tacrine
• Telithromycin
• Temazepam
• Tetrazepam
• Ticlopidine
• Triazolam
• Zafirlukast

Interactions with Food/Tobacco/Alcohol

Some medicines should not be taken around the time of eating food or certain types of food due to possible interactions. Using alcohol or tobacco with some medicines may also cause interactions. The following interactions have been chosen based on their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or provide special instructions regarding food, alcohol, or tobacco use.

• Tobacco

Using this medicine with any of the following may increase the risk of certain side effects, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or provide special instructions regarding food, alcohol, or tobacco use.

• Caffeine
• food

Other Medical Problems

Having other medical problems may affect how you can use this medicine. Be sure to inform your doctor if you have any other medical issues, especially:

• Convulsions (seizures)—Oxtriphylline may worsen this condition.

• Heart failure or
• Liver disease or
• Underactive thyroid—The effects of oxtriphylline may be increased.

Along with its required effects, a medicine may cause some unwanted effects. Not all of these side effects may happen, but if they do, they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

Less common or rare

• Heartburn and/or vomiting

Symptoms of toxicity

• Abdominal pain, continuing or severe
• confusion or change in behavior
• convulsions (seizures)
• dark or bloody vomit
• diarrhea
• dizziness or lightheadedness
• fast and/or irregular heartbeat, continuing
• nervousness or restlessness, continuing
• trembling, continuing

Some side effects may happen that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

• Headache
• fast heartbeat
• increased urination
• nausea
• nervousness
• trembling
• trouble in sleeping

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

In Canada

• Choledyl Expectorant Elixir

Chemical Class: Theophylline

This medicine works best when taken with a glass of water on an empty stomach (either 30 minutes to 1 hour before meals or 2 hours after meals) since that way it will get into the blood sooner. However, in some cases your doctor may want you to take this medicine with meals or right after meals to lessen stomach upset. If you have any questions about how you should be taking this medicine, check with your doctor.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of serious side effects.

In order for this medicine to help your medical problem, it must be taken every day in regularly spaced doses as ordered by your doctor. This is necessary to keep a constant amount of the medicine in the blood. To help keep the amount constant, do not miss any doses.

Make certain your health care professional knows if you are on any special diet, such as a high-protein, low-carbohydrate or low-protein, high-carbohydrate diet.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

After you begin taking oxtriphylline and guaifenesin combination, it is very important that your doctor check your blood level of theophylline at regular intervals to find out if your dose of oxtriphylline and guaifenesin combination needs to be changed. Do not change your dose of this medicine unless your doctor tells you to do so.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.