On this page · 8 sections

Peridex (oral rinse)

Generic name: chlorhexidine gluconate (oral rinse)

Brand names: Peridex, Periogard

Used for gingivitis
Last updated November 3, 2026 0 views
Share

What is Peridex?

Peridex is a mouthwash that kills germs and reduces bacteria in the mouth.

Peridex is used to treat gingivitis (swelling, redness, and bleeding of the gums). A dentist usually prescribes this medicine.

Peridex is not for treating all kinds of gingivitis. Use this medicine only for the condition that your dentist prescribed it for. Do not share this medicine with anyone else, even if they have the same gum symptoms as you.

Peridex may also be used for other purposes not mentioned in this medication guide.

This section was rewritten for readability and reviewed for meaning.

Warnings

Peridex can cause a rare but serious allergic reaction that could be life-threatening. Seek emergency medical help if you experience: hives, severe skin rash; wheezing, difficulty breathing; cold sweats, feeling light-headed; swelling of your face, lips, tongue, or throat.

Do not give this medication to a child or teenager without a doctor's advice. Peridex may cause severe irritation or chemical burns in young children.

This section was rewritten for readability and reviewed for meaning.

Before taking this medicine

You should not use this medication if you are allergic to Peridex.

If you have periodontal disease, you may need special treatments while using Peridex.

Do not give this medication to a child or teenager without a doctor's advice. This medicine may cause severe irritation or chemical burns in young children. Peridex is not approved for anyone younger than 18 years old.

It is not known if this medicine will harm an unborn baby. Inform your doctor if you are pregnant or plan to become pregnant.

It is not known if chlorhexidine gluconate passes into breast milk or if it could affect a nursing baby. Inform your doctor if you are breast-feeding.

This section was rewritten for readability and reviewed for meaning.

Peridex side effects

Peridex can cause a rare but serious allergic reaction that may be life-threatening. Get emergency medical help if you have any of these signs of an allergic reaction: hives, severe skin rash; wheezing, difficult breathing; cold sweats, feeling light-headed; swelling of your face, lips, tongue, or throat.

Peridex may cause serious side effects. Call your doctor at once if you have:

  • white patches or sores inside your mouth or on your lips;
  • mouth ulcers; or
  • swelling of your salivary glands (underneath your jaws).

Common side effects of Peridex may include:

  • mouth irritation;
  • tooth staining;
  • dry mouth;
  • unusual or unpleasant taste in your mouth; or
  • decreased taste sensation.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

This section was rewritten for readability and reviewed for meaning.

How should I use Peridex?

Follow all directions on your prescription label. Do not use Peridex in larger or smaller amounts or for longer than recommended.

Rinse your mouth with Peridex twice daily after brushing your teeth.

Measure your dose using the cup provided with the medication. Swish the medicine in your mouth for at least 30 seconds, then spit it out. Do not swallow the mouthwash.

Do not add water to the oral rinse. Do not rinse your mouth with water or other mouthwashes right after using Peridex.

Peridex may leave an unpleasant taste in your mouth. Do not rinse your mouth to remove this taste after using the medication. You may rinse the medicine away and reduce its effectiveness.

Use this medication for the full prescribed length of time. Your symptoms may improve before your gingivitis is completely cleared. Peridex will not treat a viral or fungal infection such as cold sores, canker sores, or oral thrush (yeast infection).

Visit your dentist at least every 6 months for preventive tooth and gum care.

Store Peridex at room temperature away from moisture and heat.

What happens if I miss a dose?

Use the missed dose as soon as you remember, but brush your teeth first. If it is almost time for your next scheduled dose, skip the missed dose. Do not use extra medicine to make up the missed dose.

This section was rewritten for readability and reviewed for meaning.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222, especially if a child has swallowed 4 or more ounces of Peridex.

An overdose of chlorhexidine would happen only if the medicine were swallowed. Overdose symptoms may include nausea, stomach pain, or the appearance of being drunk.

Peridex can stain teeth, dentures, tooth restorations, your tongue, or the inside of your mouth. Talk with your dentist about ways to remove staining from these surfaces. Stains may be harder to remove from false teeth that have scratches in their surfaces.

Avoid eating, drinking, or brushing your teeth right after using this medication.

Do not use any other mouthwash unless your doctor has told you to.

This section was rewritten for readability and reviewed for meaning.

What other drugs will affect Peridex?

It is unlikely that other medications you take by mouth or by injection will affect Peridex. However, many medications can interact with each other. Inform all of your health care providers about all the medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.

This section was rewritten for readability and reviewed for meaning.

Related medicines

Before you take this medicine: the information on this page is general and may not cover your personal circumstances. Read the label supplied with your medicine and ask a pharmacist or doctor if you are unsure, especially if you are pregnant, breastfeeding, taking other medicines or managing a long-term condition.
General medicine information Consumer-friendly language

Content is provided for education and is not medical advice. See our medical disclaimer.