Phenylephrine and ketorolac (Ophthalmic)

Ketorolac and phenylephrine ophthalmic solution is mixed with an eye irrigation solution used during cataract surgery or intraocular lens replacement. This helps keep the pupil size stable by stopping intraoperative miosis (pupil constriction) and reduces pain after eye surgery.

This medicine is to be given only by or under the direct supervision of your eye doctor (ophthalmologist).

Your eye doctor will examine your eyes closely while you are using this medicine to ensure it is working as it should and not causing any side effects.

This medicine may raise your blood pressure. Inform your doctor immediately if you have blurred vision, dizziness, nervousness, headache, a pounding sensation in your ears, or a slow or fast heartbeat.

Let your doctor know if you experience sensitivity to light while using this medicine.

In deciding to use a medicine, you and your doctor must consider the risks and benefits of the medicine. For this medicine, please consider the following:

Allergies

Inform your doctor if you have had any unusual or allergic reactions to this medicine or any other medicines. Also, let your healthcare provider know if you have any other allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Studies so far have not found any specific problems in children that would limit the usefulness of ketorolac and phenylephrine ophthalmic solution in young patients.

Geriatric

Studies so far have not found any specific problems in older adults that would limit the usefulness of ketorolac and phenylephrine ophthalmic solution in the elderly.

Breast Feeding

There are no adequate studies in women to determine the risk to infants when using this medication during breastfeeding. Consider the potential benefits and risks before taking this medication while breastfeeding.

Interactions with Medicines

Some medicines should not be used together at all, while others may be used together even if interactions could occur. In these cases, your doctor may need to adjust the dose, or other precautions may be necessary. It is very important that your healthcare provider knows if you are taking any of the medicines listed below. The following interactions have been chosen based on their potential importance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Aceclofenac
• Acemetacin
• Amtolmetin Guacil
• Aspirin
• Bromfenac
• Bufexamac
• Celecoxib
• Choline Salicylate
• Clonixin
• Clorgyline
• Dexibuprofen
• Dexketoprofen
• Diclofenac
• Diflunisal
• Dipyrone
• Droxicam
• Etodolac
• Etofenamate
• Etoricoxib
• Felbinac
• Fenoprofen
• Fepradinol
• Feprazone
• Floctafenine
• Flufenamic Acid
• Flurbiprofen
• Ibuprofen
• Indomethacin
• Iproniazid
• Isocarboxazid
• Ketoprofen
• Linezolid
• Lornoxicam
• Loxoprofen
• Lumiracoxib
• Meclofenamate
• Mefenamic Acid
• Meloxicam
• Morniflumate
• Nabumetone
• Naproxen
• Nepafenac
• Nialamide
• Niflumic Acid
• Nimesulide
• Nimesulide Beta Cyclodextrin
• Oxaprozin
• Oxyphenbutazone
• Parecoxib
• Pentoxifylline
• Phenelzine
• Phenylbutazone
• Piketoprofen
• Piroxicam
• Procarbazine
• Proglumetacin
• Propyphenazone
• Proquazone
• Rasagiline
• Rofecoxib
• Salicylic Acid
• Salsalate
• Selegiline
• Sodium Salicylate
• Sulfasalazine
• Sulindac
• Tenoxicam
• Tiaprofenic Acid
• Tolfenamic Acid
• Tolmetin
• Tranylcypromine
• Valdecoxib

Using this medicine with any of the following medicines is usually not recommended, but may be necessary in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Abciximab
• Acenocoumarol
• Anagrelide
• Apixaban
• Ardeparin
• Argatroban
• Bemiparin
• Betamethasone
• Bivalirudin
• Budesonide
• Cangrelor
• Certoparin
• Cilostazol
• Citalopram
• Clopidogrel
• Cortisone
• Dabigatran Etexilate
• Dalteparin
• Danaparoid
• Deflazacort
• Desirudin
• Desvenlafaxine
• Dexamethasone
• Dipyridamole
• Duloxetine
• Edoxaban
• Emtricitabine
• Enoxaparin
• Epoprostenol
• Eptifibatide
• Escitalopram
• Feverfew
• Fluocortolone
• Fluoxetine
• Fluvoxamine
• Fondaparinux
• Furazolidone
• Ginkgo
• Heparin
• Hydrocortisone
• Iloprost
• Lepirudin
• Levomilnacipran
• Meadowsweet
• Melphalan
• Methotrexate
• Methylprednisolone
• Midodrine
• Milnacipran
• Nadroparin
• Nefazodone
• Paramethasone
• Pargyline
• Parnaparin
• Paroxetine
• Phenindione
• Phenprocoumon
• Prasugrel
• Prednisolone
• Prednisone
• Protein C
• Reviparin
• Rivaroxaban
• Selexipag
• Sertraline
• Sibutramine
• Sulfinpyrazone
• Sulodexide
• Tenofovir Alafenamide
• Ticagrelor
• Ticlopidine
• Tinzaparin
• Tirofiban
• Treprostinil
• Venlafaxine
• Vilazodone
• Vorapaxar
• Vortioxetine
• Warfarin

Using this medicine with any of the following medicines may increase the risk of certain side effects, but using both may be the best option for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Guanethidine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used with food or certain types of food due to possible interactions. Using alcohol or tobacco with certain medicines may also cause interactions. The following interactions have been chosen based on their potential significance and are not necessarily all-inclusive.

Other Medical Problems

Other medical conditions may affect the use of this medicine. Be sure to tell your doctor if you have any other medical issues, especially:

• Allergy to NSAIDs (e.g., aspirin, diclofenac, ibuprofen, naproxen, Advil®, Aleve®, Celebrex®, Voltaren®) or
• Asthma, or a history of
• Bronchospasm (breathing problem)—Use with caution. This may worsen these conditions.

Along with its necessary effects, a medicine can also cause some unwanted effects. Not all of these side effects may happen, but if they do, you might need medical help.

Check with your doctor or nurse right away if any of the following side effects occur:

More common

• Decreased vision or other changes in vision
• loss of vision

Get emergency help right away if you experience any of the following symptoms of overdose:

Symptoms of overdose

• Fainting
• fast, pounding, or irregular heartbeat or pulse
• fear or nervousness
• headache
• nausea
• vomiting

Some side effects may happen that usually do not require medical attention. These side effects may go away during treatment as your body gets used to the medicine. Your health care professional may also be able to suggest ways to prevent or lessen some of these side effects. Check with your health care professional if any of the following side effects last or are bothersome, or if you have any questions about them:

Less common

• Feeling of having something in the eye
• red, sore eyes

Other side effects not listed may also occur in some patients. If you notice any other effects, consult your healthcare professional.

Call your doctor for medical advice about side effects. You can report side effects to the FDA at 1-800-FDA-1088.

In the U.S.

• Omidria

Available Dosage Forms:

• Solution

Therapeutic Class: Mydriatic-Cycloplegic

Pharmacologic Class: NSAID

Chemical Class: Acetic Acid (class)

Your eye doctor will give you this medicine in a hospital. It is injected into your eyes.