Plenaxis

Plenaxis reduces the amount of testosterone produced in the body.

Plenaxis is used in the palliative treatment of advanced prostate cancer.

Plenaxis may also be used for purposes other than those listed in this medication guide.

Treatment with Plenaxis may become less effective over time in some patients. Monitoring blood levels of testosterone will be done on a regular basis with blood tests to monitor the effectiveness of the medication.

Before using Plenaxis, tell your doctor if you

• have irregular heartbeats;
• have liver problems;
• have osteoporosis; or
• weigh more than 225 pounds.

You may not be able to use Plenaxis, or you may require a dosage adjustment or special monitoring during treatment.

Other, less serious side effects may be more likely to occur. Talk to your doctor if you experience

• hot flashes;
• sleep disturbances;
• breast enlargement or pain;
• diarrhea or constipation;
• swelling;
• nausea;
• dizziness;
• headache;
• fatigue; or
• changes with or difficulty urinating.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

Plenaxis must be administered by a qualified healthcare provider.

Plenaxis is administered as an injection into the muscle.

Treatment with Plenaxis may become less effective over time in some patients. Monitoring blood levels of testosterone will be done on a regular basis with blood tests to monitor the effectiveness of the medication.

It is important to use Plenaxis regularly to get the most benefit.

Plenaxis vials for injection should be stored at room temperature away from moisture and heat.

Contact your doctor if you miss a dose of Plenaxis.

An overdose of Plenaxis is unlikely to occur. If you do suspect that an overdose has occurred, contact your doctor, hospital emergency room, or poison control center for advice.

There are no restrictions on food, beverages, or activities while using Plenaxis. Follow any special instructions given by your doctor.

It is not known whether Plenaxis will interact with other medicines. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products during treatment with Plenaxis.