Polymyxin B and trimethoprim ophthalmic

Polymyxin B and trimethoprim ophthalmic (for use in the eyes) is a combination medicine used to treat eye infections that are caused by bacteria.

Polymyxin B and trimethoprim ophthalmic may also be used for reasons not mentioned in this medication guide.

This medicine is usually used once every 3 hours for 7 to 10 days. Follow all instructions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Wash your hands before using the eye drops.

To apply the eye drops:

• Tilt your head back slightly and pull down your lower eyelid to make a small pocket. Hold the dropper above your eye with the tip facing down. Look up and away from the dropper and squeeze out a drop.
• Close your eyes for 2 or 3 minutes with your head tilted down, without blinking or squinting. Gently press your finger to the inside corner of your eye for about 1 minute to prevent the liquid from draining into your tear duct.
• Use only the number of drops your doctor has prescribed. If you need to use more than one drop, wait about 5 minutes between drops.
• Wait at least 10 minutes before using any other eye drops your doctor has prescribed.

Do not touch the tip of the eye dropper or put it directly on your eye. A contaminated dropper can infect your eye, which could lead to serious vision problems.

Do not use the eye drops if the liquid has changed color or has particles in it. Call your pharmacist for new medicine.

Use this medication for the full prescribed length of time. Your symptoms may get better before the infection is completely gone. Skipping doses may also increase your risk of further infection that is resistant to antibiotics.

Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.

Use only as directed. Inform your doctor if you are taking other medicines, have other medical conditions, or have allergies.

You should not use polymyxin B and trimethoprim ophthalmic if you are allergic to polymyxin B or trimethoprim.

Tell your doctor if you are pregnant or breastfeeding.

This medicine should not be given to a child younger than 2 months old.

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

polymyxin B and trimethoprim ophthalmic may cause serious side effects. Stop using polymyxin B and trimethoprim ophthalmic and call your doctor right away if you have:

• eye pain, swelling, redness, or severe discomfort;
• crusting or drainage (may be signs of infection);
• swelling or redness of your eyelids; or
• new or worsening symptoms.

Common side effects of polymyxin B and trimethoprim ophthalmic may include:

• mild burning, stinging, or itching of your eyes.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Usual Adult Dose for Bacterial Conjunctivitis:

Instill 1 drop in the affected eye(s) every 3 hours for 7 to 10 days.Maximum dose: 6 doses/dayUses: For the treatment of mild to moderate surface ocular bacterial infections (including acute bacterial conjunctivitis) and blepharoconjunctivitis due to susceptible strains of Staphylococcus aureus, S epidermidis, Streptococcus pneumoniae, viridans streptococci, Haemophilus influenzae, Pseudomonas aeruginosa

Usual Adult Dose for Blepharoconjunctivitis:

Instill 1 drop in the affected eye(s) every 3 hours for 7 to 10 days.Maximum dose: 6 doses/dayUses: For the treatment of mild to moderate surface ocular bacterial infections (including acute bacterial conjunctivitis) and blepharoconjunctivitis due to susceptible strains of Staphylococcus aureus, S epidermidis, Streptococcus pneumoniae, viridans streptococci, Haemophilus influenzae, Pseudomonas aeruginosa

Usual Pediatric Dose for Bacterial Conjunctivitis:

2 months or older: Instill 1 drop in the affected eye(s) every 3 hours for 7 to 10 days.Maximum dose: 6 doses/dayUses: For the treatment of mild to moderate surface ocular bacterial infections (including acute bacterial conjunctivitis) and blepharoconjunctivitis due to susceptible strains of S aureus, S epidermidis, S pneumoniae, viridans streptococci, H influenzae, P aeruginosa

Usual Pediatric Dose for Blepharoconjunctivitis:

2 months or older: Instill 1 drop in the affected eye(s) every 3 hours for 7 to 10 days.Maximum dose: 6 doses/dayUses: For the treatment of mild to moderate surface ocular bacterial infections (including acute bacterial conjunctivitis) and blepharoconjunctivitis due to susceptible strains of S aureus, S epidermidis, S pneumoniae, viridans streptococci, H influenzae, P aeruginosa

Use the medicine as soon as you can, but if it is almost time for your next dose, skip the missed dose. Do not use two doses at the same time.

Seek emergency medical help or call the Poison Help line at 1-800-222-1222.

Do not use polymyxin B and trimethoprim ophthalmic while wearing contact lenses. Polymyxin B and trimethoprim ophthalmic may contain a preservative that can change the color of soft contact lenses. Wait at least 15 minutes after using this medicine before putting in your contact lenses.

Do not use any other eye medications unless your doctor instructs you to.

Medicine used in the eyes is not likely to be affected by other drugs you use. But many drugs can interact. Tell your doctor about all your current medicines, including prescription and over-the-counter medicines, vitamins, and herbal products.