Probenecid

Probenecid is used to treat gout and gouty arthritis. probenecid lowers the amount of uric acid in your body by helping it to be eliminated in your urine.

Probenecid is also sometimes given with penicillin antibiotics (including ampicillin, methicillin, oxacillin, cloxacillin, or nafcillin) to enhance their effectiveness.

Probenecid may also be used for reasons not mentioned in this medication guide.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Drink plenty of water to prevent kidney stones while you are taking probenecid.

You may be given other medications to also help prevent kidney stones. Keep using these medicines for as long as your doctor has prescribed.

If you need surgery, tell your surgeon you currently take probenecid. Probenecid may affect your body's response to anesthesia.

Call your doctor if your gout symptoms do not improve, or if they get worse. Your doctor may prescribe an additional medicine called colchicine.

Store at room temperature away from moisture, heat, and light.

You should not use probenecid if you have uric acid kidney stones, a gout attack that has already started, or a blood cell disorder.

Call your doctor if you have worsening gout symptoms.

You should not use probenecid if you are allergic to it, or if you have:

• uric acid kidney stones;
• a gout attack that has already started; or
• a blood cell disorder, such as anemia or low white blood cells.

Probenecid should not be given to a child younger than 2 years old.

Tell your doctor if you have ever had:

• kidney disease;
• a stomach ulcer; or
• kidney stones.

Tell your doctor if you are pregnant or breast-feeding.

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Probenecid may cause serious side effects. Call your doctor right away if you have:

• worsening gout symptoms;
• nausea, vomiting, stomach pain or swelling;
• painful or difficult urination;
• severe pain in your side or lower back;
• blood in your urine;
• urine that looks cloudy or foamy;
• puffy eyes, swelling in your ankles or feet, weight gain; or
• pale or yellowed skin.

Common side effects of probenecid may include:

• headache, dizziness;
• nausea, vomiting, loss of appetite;
• flushing (sudden warmth, redness, or tingly feeling);
• sore gums;
• urinating more than usual;
• itching, rash; or
• hair loss.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Take the medicine as soon as you can. If it is almost time for your next dose, skip the missed dose. Do not take two doses at the same time.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include nausea, vomiting, or stomach discomfort.

Ask a doctor or pharmacist if you feel you need to take a mild pain reliever. Avoid using any medicine that may contain aspirin or other salicylates (such as Disalsid, Doan's Extra Strength, Ecotrin, Novasal, Nuprin Backache, Salflex, Salsitab, Tricosal, Trilisate, and others).

Tell your doctor about all your other medicines, especially:

• acetaminophen (Tylenol);
• lorazepam;
• methotrexate;
• rifampin;
• diabetes medicine you take by mouth;
• a sulfa drug; or
• an NSAID (nonsteroidal anti-inflammatory drug) such as indomethacin, ketoprofen, meclofenamate, or naproxen (Aleve).

This list is not complete. Other drugs may affect probenecid, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.