Probenecid and sulopenem etzadroxil

Probenecid and sulopenem etzadroxil is a combination antibiotic used in adult women who have few or no other oral antibiotic options to treat uncomplicated urinary tract infections.

Probenecid and sulopenem etzadroxil is not for treating complicated urinary tract infections, infections that have already been treated with intravenous antibiotics, or complicated intra-abdominal infections.

Probenecid and sulopenem etzadroxil may also be used for other reasons that are not mentioned in this medication guide.

Follow all instructions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Your doctor will perform tests to ensure probenecid and sulopenem etzadroxil is the right treatment for you.

Probenecid and sulopenem etzadroxil is usually taken twice a day for 5 days.

Take with food.

Drink plenty of liquids while you are taking probenecid and sulopenem etzadroxil, especially if you are at risk of uric acid kidney stones.

Probenecid and sulopenem etzadroxil can affect the results of certain medical tests. Inform any doctor who treats you that you are using probenecid and sulopenem etzadroxil.

Continue using this medicine even if your symptoms improve quickly. Skipping doses could make your infection resistant to medication. Probenecid and sulopenem etzadroxil will not treat a viral infection (flu or a common cold).

Antibiotic medicines can cause diarrhea. Inform your doctor if you have diarrhea that is watery or bloody.

You may be given other medications to help prevent serious side effects. Continue taking these medicines for as long as your doctor has prescribed.

Store at room temperature away from moisture and heat.

Tell your doctor if you are taking any other medicines, if you have any other medical conditions, or if you have any allergies. Some medicines should not be taken with probenecid and sulopenem etzadroxil.

You should not use probenecid and sulopenem etzadroxil if you have uric acid kidney stones or a blood cell disorder.

You should not use probenecid and sulopenem etzadroxil if you are allergic to it, or if you have:

• an allergy to similar antibiotics such as meropenem, imipenem, cephalexin, cefdinir, amoxicillin, ampicillin, penicillin, and others;
• uric acid kidney stones; or
• a blood cell disorder, such as anemia or low white blood cells.

Some drugs should not be used with probenecid and sulopenem etzadroxil. Your treatment plan may change if you also use ketorolac.

Tell your doctor if you have or have ever had:

• gout;
• diarrhea caused by infection; or
• kidney disease (or if you are on dialysis).

Tell your doctor if you are pregnant or breastfeeding.

Get emergency medical help if you have signs of an allergic reaction: hives, difficulty breathing, swelling of your face, lips, tongue, or throat.

Probenecid and sulopenem etzadroxil may cause serious side effects. Call your doctor right away if you have:

• severe stomach pain, diarrhea that is watery or bloody (even if it happens months after your last dose);
• worsening gout symptoms; or
• signs of a kidney stone--pain in your side or lower back, blood in your urine, painful or difficult urination.

Common side effects of probenecid and sulopenem etzadroxil may include:

• diarrhea;
• vaginal yeast infection;
• nausea or vomiting; or
• headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Usual Adult Dose for Urinary Tract Infection:

1 tablet (Sulopenem etzadroxil 500 mg-probenecid 500 mg) orally 2 times a dayDuration of therapy: 5 daysComments:-This combination drug is not indicated for complicated urinary tract infections or complicated intra-abdominal infections, including as step-down therapy following intravenous antibacterial treatment.-This combination drug should be used only to treat uncomplicated urinary tract infection (uUTI) that are proven or strongly suspected to be caused by susceptible bacteria.-Culture and susceptibility data should be utilized in selecting or modifying antibacterial therapy.Uses:-For the treatment of uUTI caused by the designated microorganisms Escherichia coli, Klebsiella pneumoniae, or Proteus mirabilis in adult women who have limited or no alternative oral antibacterial treatment options-To reduce the development of drug-resistant bacteria and maintain the effectiveness of this combination drug and other antibacterial drugs

Take the medicine as soon as you can. Do not take two doses at the same time.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Ask a doctor or pharmacist before using over-the-counter medicines that may contain nonsteroidal anti-inflammatory drug (NSAID) such as ibuprofen, naproxen, Advil, Aleve, Motrin, and others.

Many drugs can change how probenecid and sulopenem etzadroxil work, and some drugs should not be taken together. Tell your doctor about all the other medicines you use. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are mentioned here.