Pyri-500 (Oral, Injection)

Vitamins are essential substances that your body needs for growth and health. You only need them in small amounts, and they are usually found in the foods you eat. Pyridoxine (vitamin B 6) is important for breaking down proteins, carbohydrates, and fats properly.

Some health conditions may increase your need for pyridoxine. These include:

• Alcoholism
• Burns
• Diarrhea
• Dialysis
• Heart disease
• Intestinal problems
• Liver disease
• Overactive thyroid
• Stress, long-term illness, or serious injury
• Surgical removal of stomach

Additionally, infants who are fed unfortified formulas like evaporated milk may require extra pyridoxine.

Your health care professional should determine if you need more pyridoxine.

Not getting enough pyridoxine can lead to anemia (weak blood), nerve damage, seizures, skin issues, and sores in the mouth. Your doctor may prescribe pyridoxine if you have these problems.

There is no proof that pyridoxine effectively treats acne and other skin problems, alcohol intoxication, asthma, hemorrhoids, kidney stones, mental health issues, migraine headaches, morning sickness, menstrual problems, or that it stimulates appetite or milk production.

Injectable pyridoxine is administered by or under the guidance of a health care professional. Other forms of pyridoxine can be obtained without a prescription.

To maintain good health, it is important to eat a balanced and varied diet. Follow any diet plan recommended by your health care professional. If you believe you are not getting enough vitamins and/or minerals from your diet, consider taking a dietary supplement.

Pyridoxine can be found in various foods such as meats, bananas, lima beans, egg yolks, peanuts, and whole-grain cereals. Pyridoxine is not lost from food during normal cooking, although some other forms of vitamin B 6 may be.

Vitamins alone cannot replace a healthy diet and do not provide energy. Your body also requires other nutrients found in food, such as protein, minerals, carbohydrates, and fats. Vitamins often need the presence of other foods to work effectively.

The daily amount of pyridoxine needed is defined in several different ways.

• For U.S.—
• Recommended Dietary Allowances (RDAs) indicate the amount of vitamins and minerals necessary for adequate nutrition in most healthy individuals. RDAs for a specific nutrient may vary based on a person's age, sex, and physical condition (e.g., pregnancy).
• Daily Values (DVs) are used on food and dietary supplement labels to show the percentage of the recommended daily amount of each nutrient that a serving provides. DV replaces the previous designation of United States Recommended Daily Allowances (USRDAs).

• For Canada—
• Recommended Nutrient Intakes (RNIs) are used to determine how much vitamins, minerals, and protein are needed for adequate nutrition and to reduce the risk of chronic disease.

Normal daily recommended intakes for pyridoxine are generally defined as follows:

• Infants and children— Birth to 3 years of age: 0.3 to 1 milligram (mg). 4 to 6 years of age: 1.1 mg. 7 to 10 years of age: 1.4 mg.
• Adolescent and adult males—1.7 to 2 mg.
• Adolescent and adult females—1.4 to 1.6 mg.
• Pregnant females—2.2 mg.
• Breast-feeding females—2.1 mg.

If you are taking this dietary supplement without a prescription, carefully read and follow any precautions on the label. For this supplement, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Problems in children have not been reported with intake of normal daily recommended amounts.

Geriatric

Problems in older adults have not been reported with intake of normal daily recommended amounts.

Breast Feeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this dietary supplement, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this dietary supplement with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Altretamine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may happen, if they do, they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

With large doses

• Clumsiness
• numbness of hands or feet

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

In the U.S.

• Aminoxin
• Pyri-500
• Rodex
• Vitabee 6

Available Dosage Forms:

• Tablet
• Tablet, Extended Release
• Solution
• Capsule
• Powder

Therapeutic Class: Nutritive Agent

Pharmacologic Class: Vitamin B (class)

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage forms (capsules, tablets, oral solution): To prevent deficiency, the amount taken by mouth is based on normal daily recommended intakes: Adult and teenage males—1.7 to 2 milligrams (mg) per day. Adult and teenage females—1.4 to 1.6 mg per day. Pregnant females—2.2 mg per day. Breast-feeding females—2.1 mg per day. Children 7 to 10 years of age—1.4 mg per day. Children 4 to 6 years of age—1.1 mg per day. Children birth to 3 years of age—0.3 to 1 mg per day. To treat deficiency: Adults, teenagers, and children—Treatment dose is determined by prescriber for each individual based on the severity of deficiency.

To use the extended-release capsule form of this dietary supplement:

• Swallow the capsule whole.
• Do not crush, break, or chew before swallowing.
• If the capsule is too large to swallow, you may mix the contents of the capsule with jam or jelly and swallow without chewing.

To use the extended-release tablet form of this dietary supplement:

• Swallow the tablet whole.
• Do not crush, break, or chew before swallowing.

Missed Dose

If you miss a dose of this medicine, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.