Qbrexza (glycopyrronium cloth)

Qbrexza (glycopyrronium cloth) is applied to the skin under the arms to treat excessive sweating (hyperhidrosis) in adults and children who are 9 years old or older.

Qbrexza may also be used for other reasons not mentioned in this medication guide.

Follow all instructions on your medicine label and package. Inform all your healthcare providers about all your medical conditions, allergies, and all medicines you take.

You should not use Qbrexza if you have:

• ulcerative colitis or other serious bowel problems;
• glaucoma;
• myasthenia gravis; or
• Sjogren's syndrome.

Tell your doctor if you have ever had:

• bladder obstruction or other urination problems,
• kidney disease; or
• an enlarged prostate.

Tell your doctor if you are pregnant or breast-feeding.

Get emergency medical help if you notice signs of an allergic reaction: hives; trouble breathing; swelling of your face, lips, tongue, or throat.

Qbrexza may cause serious side effects. Stop using Qbrexza and call your doctor right away if you experience:

• little or no sweating in hot conditions (such as during exercise or when exposed to high heat);
• fever, hot or red skin;
• difficulty emptying your bladder (or you have a weak urine stream);
• painful or difficult urination;
• increased urination;
• rapid or shallow breathing;
• weak and rapid pulse; or
• feeling light-headed, as if you might faint.

Common side effects of Qbrexza may include:

• burning, stinging, or redness in your underarms;
• urination problems;
• blurred vision, dilated pupils (your eyes may be more sensitive to light);
• headache;
• dry nose, sore throat;
• dry eyes; or
• constipation.

This is not a complete list of side effects, and others may occur. Call your doctor for medical advice about side effects. You can report side effects to the FDA at 1-800-FDA-1088.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Apply only to clean, dry underarm skin. Do not use on open wounds or broken skin.

Do not cover treated skin with a bandage or with plastic.

Use a single Qbrexza cloth on both underarms once every 24 hours. Then throw the cloth away.

Wash your hands after handling a Qbrexza cloth. Any medicine left on your hands could cause blurred vision if you later touch your eyes.

Store at room temperature away from moisture and heat.

Keep each cloth in the sealed pouch until it is time for you to apply the medicine.

Glycopyrrolate cloths are flammable. Do not use near high heat or open flame.

Use the medicine as soon as you can, but skip the missed dose if it is close to the time for your next dose. Do not use two cloths at the same time.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include dry mouth, constipation, problems urinating, feeling warm or tingly, or fast heartbeats.

Avoid getting overheated or dehydrated while exercising and in hot weather. Qbrexza decreases sweating, and you may be more likely to get heat stroke.

Qbrexza may cause blurred vision and may affect your reactions. Avoid driving or doing dangerous activities until you know how this medicine will affect you.

Avoid getting this medicine in your eyes.

Tell your doctor about all your other medicines, especially:

• medicine to treat depression, anxiety, mood disorders, or mental illness;
• cold or allergy medicine (Benadryl and others);
• medicine to treat Parkinson's disease;
• medicine to treat stomach problems, motion sickness, or irritable bowel syndrome;
• medicine to treat overactive bladder; or
• bronchodilator asthma medication.

This list is not complete. Other drugs may affect Qbrexza, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

• How do you use a Qbrexza cloth?