Restall (Intramuscular)

Hydroxyzine injection is used to help control anxiety and tension caused by dental, nervous, and emotional conditions. It can also help with anxiety and promote sleep before and after surgery. This medicine is also used to relieve symptoms of an allergic reaction (e.g., hives, itchy skin) caused by asthma and chronic urticaria.

Hydroxyzine is an antihistamine. It works by blocking the effects of a substance called histamine, which the body produces. This medicine is also used to control withdrawal symptoms in alcoholic patients. It can help manage nausea and vomiting symptoms and relieve anxiety in patients with certain heart conditions.

This medicine is to be given by or under the supervision of your doctor.

Your doctor will closely monitor your progress while you or your child is receiving this medicine. This will help your doctor determine if the medicine is working properly and if you should continue to use it.

Make sure your doctor is aware if you are pregnant. Do not use this medicine during the early stages of pregnancy unless your doctor advises you to.

This medicine may cause permanent skin damage (necrosis) at the injection site. Inform your doctor immediately if you notice any side effects at the injection site, such as depressed or indented skin, blue-green to black discoloration of the skin, or pain, redness, or peeling of the skin.

This medicine will increase the effects of alcohol and other CNS depressants (medications that make you sleepy or less alert). Some examples of CNS depressants include antihistamines or medications for allergies or colds, sedatives, tranquilizers or sleeping medications, prescription pain medications or narcotics, medications for seizures or barbiturates, muscle relaxants, or anesthetics, including some dental anesthetics. Consult your doctor before taking any of these while you or your child is using this medicine.

This medicine may cause dizziness or drowsiness. Do not drive or engage in activities that could be dangerous until you know how this medicine affects you.

Inform your doctor immediately if you or your child experience any changes in your heart rhythm. You may feel dizzy or faint, or you may notice a fast, pounding, or irregular heartbeat. Ensure your doctor knows if you or anyone in your family has ever had a heart rhythm issue, such as QT prolongation.

Do not take any other medicines unless your doctor has discussed them with you. This includes both prescription and nonprescription (over-the-counter [OTC]) medicines, as well as herbal or vitamin supplements.

In deciding to use a medicine, you and your doctor will weigh the risks against the benefits. Consider the following for this medicine:

Allergies

Inform your doctor if you have ever had any unusual or allergic reactions to this medicine or any other medicines. Also, let your healthcare professional know about any other allergies, such as those to foods, dyes, preservatives, or animals. For non-prescription products, carefully read the label or package ingredients.

Pediatric

Research has not shown any specific problems in children that would limit the use of hydroxyzine injection.

Geriatric

Research has not shown any specific problems in the elderly that would limit the use of hydroxyzine injection. However, older patients are more likely to experience unwanted side effects (like confusion or drowsiness) and age-related issues with the liver, kidneys, or heart. This may require caution and possible dose adjustments for those receiving hydroxyzine injection.

Breast Feeding

There are no sufficient studies in women to determine the risk to infants when using this medication during breastfeeding. Consider the potential benefits and the risks before taking this medication while breastfeeding.

Interactions with Medicines

Some medicines should not be used together at all, while others may be used together with caution. In these cases, your doctor might change the dose or take other precautions. It is crucial for your healthcare professional to know if you are taking any of the medicines listed below. The following interactions are highlighted based on their potential significance and are not an exhaustive list.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide against treating you with this medication or may change some of your other medications.

• Bepridil
• Calcium Oxybate
• Cisapride
• Dronedarone
• Levoketoconazole
• Magnesium Oxybate
• Mesoridazine
• Pimozide
• Piperaquine
• Potassium Citrate
• Potassium Oxybate
• Saquinavir
• Sodium Oxybate
• Sparfloxacin
• Terfenadine
• Thioridazine
• Tranylcypromine
• Ziprasidone

Using this medicine with any of the following medicines is usually not recommended but may be necessary in some cases. If both medicines are prescribed, your doctor may change the dose or frequency for one or both.

• Adagrasib
• Alfentanil
• Alfuzosin
• Alprazolam
• Amantadine
• Amiodarone
• Amisulpride
• Amitriptyline
• Anagrelide
• Apomorphine
• Aripiprazole
• Aripiprazole Lauroxil
• Arsenic Trioxide
• Asenapine
• Astemizole
• Atazanavir
• Azithromycin
• Bedaquiline
• Benzhydrocodone
• Bromazepam
• Bromopride
• Buprenorphine
• Bupropion
• Buserelin
• Butorphanol
• Cannabidiol
• Cannabis
• Carbinoxamine
• Ceritinib
• Cetirizine
• Chloroquine
• Chlorpromazine
• Ciprofloxacin
• Citalopram
• Clarithromycin
• Clofazimine
• Clomipramine
• Clonazepam
• Clothiapine
• Clozapine
• Codeine
• Crizotinib
• Cyclobenzaprine
• Dabrafenib
• Daridorexant
• Dasatinib
• Degarelix
• Delamanid
• Desipramine
• Deslorelin
• Deutetrabenazine
• Dexmedetomidine
• Dihydrocodeine
• Disopyramide
• Dofetilide
• Dolasetron
• Domperidone
• Doxepin
• Doxylamine
• Droperidol
• Ebastine
• Efavirenz
• Encorafenib
• Entrectinib
• Eribulin
• Erythromycin
• Escitalopram
• Esketamine
• Etrasimod
• Famotidine
• Felbamate
• Fentanyl
• Fexinidazole
• Fingolimod
• Flecainide
• Flibanserin
• Fluconazole
• Fluoxetine
• Formoterol
• Foscarnet
• Fosphenytoin
• Fostemsavir
• Gabapentin
• Gabapentin Enacarbil
• Galantamine
• Gatifloxacin
• Gemifloxacin
• Gepirone
• Glasdegib
• Glucagon
• Glycopyrrolate
• Glycopyrronium Tosylate
• Gonadorelin
• Goserelin
• Granisetron
• Halofantrine
• Haloperidol
• Histrelin
• Hydrocodone
• Hydromorphone
• Hydroquinidine
• Hydroxychloroquine
• Ibutilide
• Iloperidone
• Imipramine
• Inotuzumab Ozogamicin
• Itraconazole
• Ivabradine
• Ivosidenib
• Ketamine
• Ketoconazole
• Lacosamide
• Lapatinib
• Lefamulin
• Lemborexant
• Lenvatinib
• Leuprolide
• Levocetirizine
• Levofloxacin
• Levorphanol
• Lofexidine
• Loxapine
• Lumefantrine
• Macimorelin
• Meclizine
• Mefloquine
• Meperidine
• Methacholine
• Methadone
• Metoclopramide
• Metronidazole
• Midazolam
• Mifepristone
• Mirtazapine
• Mizolastine
• Mobocertinib
• Moricizine
• Morphine
• Morphine Sulfate Liposome
• Moxifloxacin
• Nafarelin
• Nalbuphine
• Nelfinavir
• Nilotinib
• Norfloxacin
• Octreotide
• Ofloxacin
• Olanzapine
• Ondansetron
• Osilodrostat
• Osimertinib
• Oxaliplatin
• Oxycodone
• Oxymorphone
• Ozanimod
• Pacritinib
• Paliperidone
• Panobinostat
• Papaverine
• Paroxetine
• Pasireotide
• Pazopanib
• Pentamidine
• Pentazocine
• Periciazine
• Perphenazine
• Phenobarbital
• Pimavanserin
• Pipamperone
• Pitolisant
• Ponesimod
• Posaconazole
• Pregabalin
• Primidone
• Probucol
• Procainamide
• Prochlorperazine
• Promethazine
• Propafenone
• Protriptyline
• Quetiapine
• Quinidine
• Quinine
• Quizartinib
• Ranolazine
• Relugolix
• Remifentanil
• Remimazolam
• Revefenacin
• Ribociclib
• Risperidone
• Ritonavir
• Ropeginterferon Alfa-2b-njft
• Scopolamine
• Secretin Human
• Selpercatinib
• Sertindole
• Sertraline
• Sevoflurane
• Siponimod
• Sodium Phosphate
• Sodium Phosphate, Dibasic
• Sodium Phosphate, Monobasic
• Solifenacin
• Sorafenib
• Sotalol
• Sufentanil
• Sulpiride
• Sunitinib
• Tacrolimus
• Tamoxifen
• Tapentadol
• Telaprevir
• Telavancin
• Telithromycin
• Tetrabenazine
• Tiotropium
• Tolterodine
• Topiramate
• Toremifene
• Tramadol
• Trazodone
• Triclabendazole
• Trimipramine
• Triptorelin
• Vandetanib
• Vardenafil
• Vemurafenib
• Venlafaxine
• Vilanterol
• Vinflunine
• Voclosporin
• Voriconazole
• Vorinostat
• Zolpidem
• Zuclopenthixol
• Zuranolone

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be taken around the time of eating food or specific types of food due to possible interactions. Using alcohol or tobacco with certain medicines may also lead to interactions. Talk to your healthcare professional about using your medicine with food, alcohol, or tobacco.

Other Medical Problems

Having other medical problems may affect how this medicine works. Make sure to tell your doctor if you have any other medical issues, especially:

• Electrolyte imbalance or
• Heart attack or
• Heart disease or
• Uncompensated heart failure or
• Family history of heart rhythm problems (e.g., long QT syndrome, slow heartbeat)—Use with caution. Side effects may worsen.

• Heart rhythm problems (e.g.,

Along with its necessary effects, a medicine may cause some unwanted effects. While not all of these side effects may happen, if they do, they might need medical attention.

Check with your doctor or nurse right away if any of the following side effects occur:

Incidence not known

• Bleeding, blistering, burning, coldness, skin discoloration, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
• blue-green to black skin discoloration
• pain, redness, or skin sloughing at the injection site

Some side effects may happen that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Your health care professional may also be able to suggest ways to prevent or lessen some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome, or if you have any questions about them:

Rare

• Shakiness in the legs, arms, hands, or feet
• trembling or shaking of the hands or feet

Incidence not known

• Drowsiness
• dry mouth

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

In the U.S.

• Hyzine
• Restall
• Vistacot
• Vistaril IM

Available Dosage Forms:

• Solution

Therapeutic Class: Respiratory Agent

Pharmacologic Class: Hydroxyzine

Chemical Class: Hydroxyzine

A nurse or other trained health professional will give you or your child this medicine in a hospital. This medicine is given as a shot into a muscle.

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