Revonto (injection)

Revonto is used to treat or prevent muscle stiffness or twitching caused by malignant hyperthermia (a quick rise in body temperature and severe muscle contractions) that can happen during surgery with certain types of anesthesia.

Revonto may also be used for other reasons not mentioned in this medication guide.

Use only as directed. Inform your doctor if you are taking other medicines or have other medical conditions or allergies.

Tell your doctor if you have or have ever had health problems or if you are using other medications.

It is not known if Revonto will harm an unborn baby. Tell your doctor if you are pregnant or planning to become pregnant.

Do not breastfeed while using Revonto, and for at least 3 days after your last dose.

Get emergency medical help if you notice signs of an allergic reaction: hives, difficulty breathing, swelling of your face, lips, tongue, or throat.

Tell your healthcare providers immediately if you experience:

• loss of grip strength, loss of balance, and weakness in the legs;
• shortness of breath;
• trouble swallowing;
• dizziness, extreme drowsiness, or suddenly falling asleep, even if you felt alert; or
• pain, burning, warmth, redness, bruising, irritation, or changes in the skin where the injection was given.

Common side effects of Revonto may include:

• nausea;
• skin redness; or
• pain, bruising, swelling, or irritation at the injection site.

This is not a complete list of side effects, and others may happen. Contact your doctor for medical advice about side effects. You can report side effects to the FDA at 1-800-FDA-1088.

Revonto is injected into a vein by a healthcare provider in a medical setting.

Tell your medical caregivers if you feel any burning or pain when Revonto is injected.

In a medical setting, it is unlikely that you will miss a dose.

In a medical setting, an overdose will be treated quickly.

Do not drive or engage in hazardous activities until you understand how Revonto affects you. Your reactions could be impaired. Revonto may cause a light-headed feeling that can last up to 48 hours.

This medication can cause muscle weakness (especially in your hands and legs) and difficulty swallowing. Use caution with daily activities to avoid injury until your muscle strength has fully returned.

Using Revonto with other medications that cause drowsiness can make this effect worse. Consult your doctor before taking opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Inform your doctor about all your other medications, especially:

• a heart or blood pressure medication called a calcium channel blocker; or
• vecuronium (a muscle relaxer used during medical procedures).

This list is not complete. Other medications may interact with Revonto, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are included here.