Revonto (Intravenous)

Dantrolene is used to prevent or treat a condition called malignant hyperthermia that can happen in some patients during or after surgery or anesthesia. Malignant hyperthermia includes symptoms like very high fever, fast and irregular heartbeat, and breathing issues. It is thought that the risk of developing malignant hyperthermia runs in families.

This medicine is available only with your doctor's prescription.

Your doctor will only give you a few doses of this medicine until your condition improves, and then you will be switched to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor.

This medicine may cause drowsiness, dizziness, or muscle weakness in some people. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert or well-coordinated.

In deciding to use a medicine, it is important to consider the risks of taking it against the benefits it may provide. This decision will be made together with your doctor. For this medicine, consider the following:

Allergies

Inform your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also, let your healthcare professional know about any other types of allergies, like those to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Studies conducted so far have not shown any pediatric-specific issues that would limit the use of dantrolene in children.

Geriatric

While specific studies on how age affects the effects of dantrolene in older adults have not been conducted, no geriatric-specific problems have been reported so far. However, older patients are more likely to have age-related kidney, liver, or heart issues, which may require caution when using dantrolene.

Breast Feeding

There are no adequate studies in women to determine the risk to infants when using this medication during breastfeeding. Consider the potential benefits and risks before taking this medication while breastfeeding.

Interactions with Medicines

Some medicines should not be used together at all, while in other cases, two different medicines can be used together, even if an interaction might happen. In these situations, your doctor may adjust the dose, or other precautions may be necessary. It is especially important for your healthcare professional to know if you are taking any of the medicines listed below while receiving this medicine. The following interactions have been chosen based on their potential importance and do not cover all possible interactions.

Using this medicine with any of the following medicines is usually not recommended, but may be necessary in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you take one or both medicines.

• Alprazolam
• Amlodipine
• Amobarbital
• Aprobarbital
• Buprenorphine
• Butabarbital
• Butalbital
• Calcium Oxybate
• Carisoprodol
• Chloral Hydrate
• Chlordiazepoxide
• Chlorzoxazone
• Cinnarizine
• Clevidipine
• Clobazam
• Clonazepam
• Clorazepate
• Diazepam
• Diltiazem
• Estazolam
• Ethchlorvynol
• Felodipine
• Flunitrazepam
• Flurazepam
• Halazepam
• Isradipine
• Ketazolam
• Levoketoconazole
• Lorazepam
• Lormetazepam
• Magnesium Oxybate
• Medazepam
• Mephenesin
• Mephobarbital
• Meprobamate
• Metaxalone
• Methadone
• Methocarbamol
• Methohexital
• Methotrexate
• Midazolam
• Nicardipine
• Nifedipine
• Nimodipine
• Nisoldipine
• Nitrazepam
• Oxazepam
• Oxycodone
• Pentobarbital
• Pexidartinib
• Phenobarbital
• Potassium Oxybate
• Prazepam
• Primidone
• Quazepam
• Secobarbital
• Sodium Oxybate
• Tapentadol
• Temazepam
• Thiopental
• Triazolam
• Verapamil

Interactions with Food/Tobacco/Alcohol

Some medicines should not be taken around the time of eating food or certain types of food because interactions may occur. Using alcohol or tobacco with certain medicines may also lead to interactions. Talk with your healthcare professional about using your medicine with food, alcohol, or tobacco.

Along with its needed effects, a medicine may cause some unwanted effects. Not all of these side effects may occur, but if they do, they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Rare

• Blue lips and fingernails
• Chest pain
• Coughing that sometimes produces a pink frothy sputum
• Difficult, fast, noisy breathing, sometimes with wheezing
• Difficulty swallowing
• Dizziness
• Fast heartbeat
• Hives
• Increased sweating
• Itching
• Pale skin
• Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• Shortness of breath
• Skin rash
• Swelling in legs and ankles
• Tightness in chest
• Tissue necrosis
• Unusual tiredness or weakness
• Wheezing

Incidence not known

• Changes in skin color, pain, tenderness, or swelling of foot or leg

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Your health care professional may also be able to tell you how to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Rare

• Flushing or redness of skin
• Unusually warm skin

Incidence not known

• Drowsiness
• Muscle weakness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

In the U.S.

• Dantrium Intravenous
• Revonto
• Ryanodex

Available Dosage Forms:

• Powder for Solution
• Powder for Suspension

Therapeutic Class: Skeletal Muscle Relaxant, Direct Acting

Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given through a needle placed in one of your veins.