Ryanodex (injection)

Ryanodex is used to treat or prevent muscle stiffness or twitching caused by malignant hyperthermia (a quick rise in body temperature and severe muscle contractions) that can happen during surgery with certain kinds of anesthesia.

Ryanodex may also be used for reasons not mentioned in this medication guide.

Use only as directed. Inform your doctor if you are taking other medicines, have other medical conditions, or have allergies.

Tell your doctor if you have or ever had health problems or use other medications.

It is not known if Ryanodex will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Do not breastfeed while using Ryanodex, and for at least 3 days after your last dose.

Get emergency medical help if you have signs of an allergic reaction: hives, difficulty breathing, swelling of your face, lips, tongue, or throat.

Tell your medical caregivers right away if you have:

• loss of grip strength, loss of balance and weakness in the legs;
• shortness of breath;
• trouble swallowing;
• dizziness, extreme drowsiness, suddenly falling asleep even after feeling alert; or
• pain, burning, warmth, redness, bruising, irritation, or skin changes at the injection site.

Common side effects of Ryanodex may include:

• nausea;
• skin redness; or
• pain, bruising, swelling, or irritation at the injection site.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Ryanodex is injected into a vein by a healthcare provider in a medical setting.

Tell your medical caregivers if you feel any burning or pain when Ryanodex is injected.

In a medical setting, it is unlikely that you will miss a dose.

In a medical setting, an overdose will be treated quickly.

Do not drive or engage in hazardous activities until you know how Ryanodex will affect you. Your reactions could be impaired. Ryanodex may cause a light-headed feeling that may last for up to 48 hours.

This medication can cause muscle weakness (especially in your hands and legs) and difficulty swallowing. Use caution with daily activities to avoid injury until your muscle strength has fully returned.

Using Ryanodex with other medicines that make you sleepy can make this effect worse. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Tell your doctor about all your other medicines, especially:

• a heart or blood pressure medicine called a calcium channel blocker; or
• vecuronium (a muscle relaxer used during medical procedures).

This list is not complete. Other medicines may affect Ryanodex, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.