Ryanodex (Intravenous)

Dantrolene is used to prevent or treat a medical condition called malignant hyperthermia, which can happen in some patients during or after surgery or anesthesia. Malignant hyperthermia includes symptoms like very high fever, a fast and irregular heartbeat, and breathing difficulties. It is thought that the risk of developing malignant hyperthermia runs in families.

This medicine is available only with your doctor's prescription.

Your doctor will only give you a few doses of this medicine until your condition gets better, and then you will be switched to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor.

This medicine may cause drowsiness, dizziness, or muscle weakness in some people. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you feel dizzy or are not alert or well-coordinated.

In deciding to use a medicine, you and your doctor will weigh the risks of taking it against the benefits it may provide. Here are some important points to consider:

Allergies

Inform your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also, let your healthcare professional know about any other allergies you have, such as to foods, dyes, preservatives, or animals. For non-prescription products, carefully read the label or package ingredients.

Pediatric

Research done so far has not shown any specific problems in children that would limit the use of dantrolene.

Geriatric

While studies on how age affects dantrolene's effects in older adults have not been done, there are no specific problems documented for this age group. However, elderly patients are more likely to have age-related kidney, liver, or heart issues, which may require caution when using dantrolene.

Breast Feeding

There are no sufficient studies in women to determine the risk to infants when using this medication while breastfeeding. Consider the potential benefits against the potential risks before using this medication during breastfeeding.

Interactions with Medicines

Some medicines should not be used together at all, while others may be used together even if an interaction could happen. In these cases, your doctor may need to adjust the dose or take other precautions. It is very important for your healthcare professional to know if you are taking any of the medicines listed below while you are receiving this medicine. The following interactions are based on their potential importance and are not a complete list.

Using this medicine with any of the following medicines is usually not recommended, but may be necessary in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both medicines.

• Alprazolam
• Amlodipine
• Amobarbital
• Aprobarbital
• Buprenorphine
• Butabarbital
• Butalbital
• Calcium Oxybate
• Carisoprodol
• Chloral Hydrate
• Chlordiazepoxide
• Chlorzoxazone
• Cinnarizine
• Clevidipine
• Clobazam
• Clonazepam
• Clorazepate
• Diazepam
• Diltiazem
• Estazolam
• Ethchlorvynol
• Felodipine
• Flunitrazepam
• Flurazepam
• Halazepam
• Isradipine
• Ketazolam
• Levoketoconazole
• Lorazepam
• Lormetazepam
• Magnesium Oxybate
• Medazepam
• Mephenesin
• Mephobarbital
• Meprobamate
• Metaxalone
• Methadone
• Methocarbamol
• Methohexital
• Methotrexate
• Midazolam
• Nicardipine
• Nifedipine
• Nimodipine
• Nisoldipine
• Nitrazepam
• Oxazepam
• Oxycodone
• Pentobarbital
• Pexidartinib
• Phenobarbital
• Potassium Oxybate
• Prazepam
• Primidone
• Quazepam
• Secobarbital
• Sodium Oxybate
• Tapentadol
• Temazepam
• Thiopental
• Triazolam
• Verapamil

Interactions with Food/Tobacco/Alcohol

Some medicines should not be taken around the time of eating food or certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions. Talk to your healthcare professional about using your medicine with food, alcohol, or tobacco.

Along with its necessary effects, a medicine may cause some unwanted effects. Not all of these side effects may happen, but if they do, they may require medical attention.

Check with your doctor or nurse right away if any of the following side effects happen:

Rare

• Blue lips and fingernails
• Chest pain
• Coughing that sometimes produces a pink frothy sputum
• Difficult, fast, noisy breathing, sometimes with wheezing
• Difficulty swallowing
• Dizziness
• Fast heartbeat
• Hives
• Increased sweating
• Itching
• Pale skin
• Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• Shortness of breath
• Skin rash
• Swelling in legs and ankles
• Tightness in chest
• Tissue necrosis
• Unusual tiredness or weakness
• Wheezing

Incidence not known

• Changes in skin color, pain, tenderness, or swelling of foot or leg

Some side effects may occur that usually do not need medical attention. These side effects may disappear during treatment as your body adjusts to the medicine. Also, your healthcare professional may be able to suggest ways to prevent or lessen some of these side effects. Check with your healthcare professional if any of the following side effects continue, are bothersome, or if you have any questions about them:

Rare

• Flushing or redness of skin
• Unusually warm skin

Incidence not known

• Drowsiness
• Muscle weakness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

In the U.S.

• Dantrium Intravenous
• Revonto
• Ryanodex

Available Dosage Forms:

• Powder for Solution
• Powder for Suspension

Therapeutic Class: Skeletal Muscle Relaxant, Direct Acting

Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given through a needle placed in one of your veins.