Sodium chloride (inhalation)

Sodium chloride is the chemical name for salt. Sodium chloride can reduce some types of bacteria in certain body fluids, like saliva.

Sodium chloride (inhalation) is used to generate sputum (mucus or phlegm) from the mouth to help improve lung function in people with cystic fibrosis, or to collect sputum for medical testing. This medication may also be used to dilute other medications inhaled through a nebulizer.

Sodium chloride (inhalation) may also be used for other reasons not mentioned in this medication guide.

Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Sodium chloride (inhalation) is given using a nebulizer. You will inhale the medication through a face mask, mouthpiece, or other device connected to the nebulizer.

Your doctor, nurse, or other healthcare provider can show you how to properly use the nebulizer.

Sodium chloride is a liquid that is placed into the medication chamber of the nebulizer. A mouthpiece or face mask is then attached to the drug chamber, along with an air compressor.

To prepare for inhaling sodium chloride (inhalation) through a nebulizer, you may be given another inhaled medication to prevent bronchospasm (muscle contractions within the airways of the lungs). Your doctor may also ask you to blow your nose, rinse your mouth with water, or wipe the inside of your mouth with a tissue. Follow your doctor's instructions carefully for best results.

In most cases, you will use this medication while you are sitting upright in a comfortable position. Breathe slowly and evenly while you are using the mask, mouthpiece, or other breathing device. You may also be given a nose clip to wear that will close your nasal passages so that you inhale only through your mouth.

If you are using this medication as part of a sputum test, you will need to spit about every 5 minutes or as directed by your healthcare provider. Cough deeply from your chest to produce an optimal specimen for testing.

Continue breathing through the nebulizer for as long as directed by your doctor. Once you have completed the inhalation for the prescribed amount of time, throw away any liquid that is left in the medicine chamber. Do not save it for later use.

If you store sodium chloride (inhalation) at home, keep it at room temperature away from moisture and heat.

Before using sodium chloride, inform your doctor about all your medical conditions and allergies. Also, let your doctor know if you are pregnant or breast-feeding. In some situations, you may not be able to use sodium chloride, or your dose may need to be adjusted, or you may need to take special precautions.

Inform your doctor about all other medications you are taking, especially potassium supplements, diuretics, steroids, blood pressure medications, or any medications that contain sodium (like Alka-Seltzer or Zegrid).

Contact your caregiver immediately if you experience chest pain, difficulty breathing, swelling in your hands or feet, fatigue, muscle twitching, confusion, irregular heart rate, extreme thirst, increased or decreased urination, leg discomfort, muscle weakness or feeling weak, or if you feel like you might faint.

You should not use this medication if you have ever had an allergic reaction to sodium chloride.

To ensure sodium chloride is safe for you, inform your doctor if you have:

• asthma;
• heart disease or high blood pressure;
• epilepsy;
• kidney or liver disease;
• migraine headaches;
• any type of edema (swelling);
• if you have recently had surgery; or
• if you are on a low-salt diet.

FDA pregnancy category C. It is not known whether sodium chloride (inhalation) is harmful to an unborn baby. Inform your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether sodium chloride passes into breast milk or if it could harm a nursing baby. Inform your doctor if you are breast-feeding a baby.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your caregiver right away if you have:

• chest pain, trouble breathing;
• feeling light-headed, like you might pass out;
• swelling in your hands or feet;
• tiredness, muscle twitching;
• confusion, uneven heart rate, extreme thirst, increased or decreased urination, leg discomfort, muscle weakness or a limp feeling.

Other common side effects may include a salty taste or slight burning or irritation in your mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Since sodium chloride (inhalation) is sometimes used only when needed, you might not have a regular dosing schedule. If you are using the medication regularly, take the missed dose as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose. Do not use extra medicine to make up for the missed dose.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

• Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Tell your doctor about all medicines you are using, and any you start or stop using while you are being treated with sodium chloride, especially:

• potassium supplements;
• a diuretic or "water pill";
• a steroid such as prednisone, fluticasone, mometasone, dexamethasone, and others;
• blood pressure medication; or
• medication that contains sodium, such as Alka-Seltzer or Zegrid (omeprazole and sodium bicarbonate).

This list is not complete. Other drugs may interact with sodium chloride, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Find detailed information on biosimilars for this medication.