Sojourn (Inhalation)

Inhaled sevoflurane is used to induce general anesthesia (loss of consciousness) before and during surgery. It is part of a group of medicines called general anesthetics.

This medicine must be given only by or under the direct supervision of a doctor.

Your doctor will monitor you closely after you receive this medicine. This will help your doctor see if the medicine is working as it should. Blood and urine tests may be needed to check for unwanted effects.

Hyperkalemia may happen rarely after receiving this medicine. Tell your doctor immediately if you experience confusion, irregular heartbeat, nausea or vomiting, numbness or tingling in your hands, feet, or legs, or trouble breathing after receiving this medicine.

This medicine may cause malignant hyperthermia (high body temperature). Contact your doctor right away if you have a fast heartbeat, high fever, or stiff muscles.

Reach out to your doctor immediately if you have black, tarry stools, chills, dark urine, dizziness, fever, general tiredness or weakness, headache, itching, light-colored stools, loss of appetite, nausea and vomiting, upper right stomach pain, vomiting of blood, or yellowing of your eyes and skin. These may be signs of a serious liver problem.

Get in touch with your doctor right away if you notice any changes in your heart rhythm. You may feel dizzy or faint, or you might experience a fast, pounding, or uneven heartbeat. Make sure your doctor knows if you have had a heart rhythm problem, including QT prolongation.

This medicine may cause severe bradycardia (slow heartbeat) in patients with Down syndrome. Contact your doctor immediately if you or your child has chest pain or discomfort, lightheadedness, dizziness, or fainting, slow or irregular heartbeat, trouble breathing, or unusual tiredness.

General anesthetics may cause some people to feel drowsy, tired, or weak. They may also lead to issues with coordination and thinking. Therefore, after receiving a general anesthetic, do not drive, operate machines, or do anything else that could be dangerous if you are not alert.

Do not take other medicines unless you have discussed them with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

In deciding to use a medicine, you and your doctor must weigh the risks of taking it against the benefits. Consider the following for this medicine:

Allergies

Inform your doctor if you have ever had any unusual or allergic reactions to this medicine or any others. Also, let your healthcare professional know about any other allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Studies to date have not shown any specific problems in children that would limit the use of inhaled sevoflurane. However, children may experience more unwanted side effects, such as brain, nerve, or heart problems, which may need caution when using this medicine.

Geriatric

Studies conducted so far have not indicated any specific problems in the elderly that would limit the use of inhaled sevoflurane.

Breast Feeding

There are no adequate studies in women to determine the risk to infants when using this medicine during breastfeeding. Consider the potential benefits and risks before taking this medicine while breastfeeding.

Interactions with Medicines

Some medicines should never be used together, while others may be used together even if interactions could happen. In these cases, your doctor may adjust the dose or take other precautions. It's especially important for your healthcare professional to know if you are taking any of the following medicines while receiving this medicine. The following interactions are highlighted for their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Bepridil
• Cisapride
• Dronedarone
• Levoketoconazole
• Mesoridazine
• Pimozide
• Piperaquine
• Saquinavir
• Sparfloxacin
• Terfenadine
• Thioridazine
• Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be necessary in some cases. If both medicines are prescribed together, your doctor may adjust the dose or frequency of use for one or both medicines.

• Adagrasib
• Alfentanil
• Alfuzosin
• Amiodarone
• Amisulpride
• Amitriptyline
• Anagrelide
• Apomorphine
• Aripiprazole
• Aripiprazole Lauroxil
• Arsenic Trioxide
• Asenapine
• Astemizole
• Atazanavir
• Azithromycin
• Bedaquiline
• Buprenorphine
• Bupropion
• Buserelin
• Ceritinib
• Chloroquine
• Chlorpromazine
• Ciprofloxacin
• Citalopram
• Clarithromycin
• Clofazimine
• Clomipramine
• Clothiapine
• Clozapine
• Crizotinib
• Cyclobenzaprine
• Dabrafenib
• Dasatinib
• Degarelix
• Delamanid
• Desipramine
• Deslorelin
• Deutetrabenazine
• Dexmedetomidine
• Dexmethylphenidate
• Disopyramide
• Dofetilide
• Dolasetron
• Domperidone
• Donepezil
• Doxepin
• Droperidol
• Ebastine
• Efavirenz
• Encorafenib
• Entrectinib
• Eribulin
• Erythromycin
• Escitalopram
• Etrasimod
• Famotidine
• Felbamate
• Fexinidazole
• Fingolimod
• Flecainide
• Fluconazole
• Fluoxetine
• Formoterol
• Foscarnet
• Fosphenytoin
• Fostemsavir
• Galantamine
• Gatifloxacin
• Gemifloxacin
• Gepirone
• Glasdegib
• Gonadorelin
• Goserelin
• Granisetron
• Halofantrine
• Haloperidol
• Histrelin
• Hydroquinidine
• Hydroxychloroquine
• Hydroxyzine
• Ibutilide
• Iloperidone
• Imipramine
• Inotuzumab Ozogamicin
• Itraconazole
• Ivabradine
• Ivosidenib
• Ketoconazole
• Lapatinib
• Lefamulin
• Lenvatinib
• Leuprolide
• Levofloxacin
• Lofexidine
• Lumefantrine
• Macimorelin
• Mefloquine
• Methadone
• Methylphenidate
• Metronidazole
• Mifepristone
• Mirtazapine
• Mizolastine
• Mobocertinib
• Moxifloxacin
• Nafarelin
• Nilotinib
• Nitrous Oxide
• Norepinephrine
• Norfloxacin
• Octreotide
• Ofloxacin
• Olanzapine
• Ondansetron
• Osilodrostat
• Osimertinib
• Oxaliplatin
• Ozanimod
• Pacritinib
• Paliperidone
• Panobinostat
• Paroxetine
• Pasireotide
• Pazopanib
• Pentamidine
• Perphenazine
• Phenobarbital
• Pimavanserin
• Pitolisant
• Ponesimod
• Posaconazole
• Primidone
• Probucol
• Procainamide
• Prochlorperazine
• Promethazine
• Propafenone
• Protriptyline
• Quetiapine
• Quinidine
• Quinine
• Quizartinib
• Ranolazine
• Relugolix
• Ribociclib
• Rilpivirine
• Risperidone
• Ritonavir
• Selpercatinib
• Serdexmethylphenidate
• Sertindole
• Sertraline
• Siponimod
• Sodium Phosphate
• Sodium Phosphate, Dibasic
• Sodium Phosphate, Monobasic
• Solifenacin
• Sorafenib
• Sotalol
• St John's Wort
• Sulpiride
• Sunitinib
• Tacrolimus
• Tamoxifen
• Telaprevir
• Telavancin
• Telithromycin
• Tetrabenazine
• Tolterodine
• Toremifene
• Trazodone
• Triclabendazole
• Trimipramine
• Triptorelin
• Vandetanib
• Vardenafil
• Vemurafenib
• Venlafaxine
• Vilanterol
• Vinflunine
• Voclosporin
• Voriconazole
• Vorinostat
• Zuclopenthixol

Using this medicine with any of the following medicines may increase the risk of certain side effects, but using both may be the best treatment for you. If both medicines are prescribed together, your doctor may adjust the dose or how often you use one or both medicines.

• Alcuronium
• Atracurium
• Doxacurium
• Metocurine
• Mivacurium
• Pancuronium
• Pipecuronium
• Rocuronium
• Tubocurarine
• Vecuronium

Interactions with Food/Tobacco/Alcohol

Some medicines should not be taken around the time of eating food or certain types of food due to possible interactions. Using alcohol or tobacco with certain medicines may also cause interactions. Talk to your healthcare professional about using your medicine with food, alcohol, or tobacco.

Other Medical Problems

Other medical conditions may affect the use of this medicine. Be sure to tell your doctor if you have any other medical issues, especially:

• Down syndrome—Use with caution. May cause serious heart problems (e.g., slow heartbeat, cardiac arrest) in patients with this condition.

• Heart or blood vessel disease or
• Heart rhythm problems or
• Hyperkalemia (high potassium in the blood) or
• Hypotension (low blood pressure) or
• Hypovolemia (low blood volume) or
• Kidney disease or
• Liver disease or
• Lung or breathing problems (e.g., respiratory depression)—Use with caution. May worsen these conditions.

• Hereditary problems (e.g., high risk for malignant hyperthermia)—Should not be used in patients with these issues.

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

• Blurred vision
• chest pain, tightness, or discomfort
• choking
• confusion
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• fast, pounding, or irregular heartbeat or pulse
• lightheadedness, dizziness, or fainting
• slow or irregular heartbeat
• sweating
• trouble breathing
• unable to speak
• unusual tiredness or weakness

Less common

• Low body temperature
• not breathing
• pale or blue lips, fingernails, or skin
• weak or feeble pulse

Rare

• Bleeding gums
• blood in the urine or stools
• body aches or pain
• chills
• cough
• coughing up blood
• decrease in frequency of urination
• decrease in urine volume
• difficulty in swallowing
• difficulty in passing urine (dribbling)
• extremely shallow or slow breathing
• eye pain
• fainting
• general feeling of illness
• headache
• hoarseness
• increased menstrual flow or vaginal bleeding
• nausea
• noisy breathing
• nosebleeds
• painful urination
• paralysis
• pinpoint red spots on skin
• prolonged bleeding from cuts
• red or dark brown urine
• red or black, tarry stools
• sore throat
• stuffy or runny nose
• tender, swollen glands in the neck
• trouble in swallowing
• unusual bleeding or bruising
• voice changes

Incidence not known

• Confusion as to time, place, or person
• dark urine
• hallucinations
• high fever
• hives, itching, or skin rash
• holding false beliefs that cannot be changed by fact
• increased blood pressure
• increased thirst
• light-colored stools
• lower back or side pain
• no blood pressure or pulse
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• restlessness
• rigid muscles
• seizures
• shakiness
• sleepiness
• slow to respond
• slurred speech
• stomach pain, continuing
• stopping of the heart
• swelling of the face, fingers, lower legs
• unconsciousness
• unpleasant breath odor
• unusual excitement, nervousness, or restlessness
• upper right abdominal or stomach pain
• vomiting of blood
• yellow eyes and skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Shivering
• sleepiness or unusual drowsiness

Less common

• Clumsiness
• problems with movement
• watering of the mouth

Incidence not known

• Burning, dry, or itching eyes
• change in vision
• discharge, excessive tearing
• hiccups
• impaired vision
• lack or loss of strength
• redness, pain, swelling of the eye, eyelid, or inner lining of eyelid

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

In the U.S.

• Sojourn
• Ultane
• Ultane Amerinet
• Ultane Novation

Available Dosage Forms:

• Liquid

Therapeutic Class: Volatile Liquid

Chemical Class: Haloalkane

A doctor or other trained health professional will give you this medicine in a hospital. You will inhale the medicine through a mask placed over your mouth and nose.