Sulindac

Sulindac is a nonsteroidal anti-inflammatory drug (NSAID).

Sulindac is used to relieve pain or inflammation from arthritis, ankylosing spondylitis, tendinitis, bursitis, or gout.

Sulindac may also be used for reasons not mentioned in this medication guide.

Follow all instructions on your prescription label and read all medication guides. Your doctor may change your dose from time to time. Use the smallest dose that works for your condition.

Take sulindac with food.

If you take sulindac for a long time, you may need regular medical tests.

Store at room temperature, away from moisture and heat. Keep the bottle tightly closed when you are not using it.

Sulindac can raise your chances of having a deadly heart attack or stroke. Do not use sulindac right before or after heart bypass surgery (coronary artery bypass graft, or CABG). Sulindac may also lead to bleeding in the stomach or intestines, which can be life-threatening.

Sulindac can increase your risk of a fatal heart attack or stroke, even if you have no risk factors. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Sulindac may also cause stomach or intestinal bleeding, which can be fatal. These issues can happen without warning while you are taking sulindac, especially in older adults.

You should not use sulindac if you are allergic to it, or if you have ever experienced an asthma attack or severe allergic reaction after taking aspirin or an NSAID.

Tell your doctor if you have ever had:

• heart disease, high blood pressure, high cholesterol, diabetes, or if you smoke;
• a heart attack, stroke, or blood clot;
• stomach ulcers or bleeding;
• kidney disease or kidney stones;
• liver disease;
• a pancreas disorder;
• asthma;
• fluid retention; or
• if you take aspirin to prevent heart attack or stroke.

If you are pregnant, you should not take sulindac unless your doctor advises you to. Taking an NSAID during the last 20 weeks of pregnancy can lead to serious heart or kidney problems in the unborn baby and possible complications with your pregnancy.

You should not breastfeed while using this medicine.

Sulindac is not approved for use by anyone younger than 18 years old.

Get emergency medical help if you have signs of an allergic reaction (hives, sneezing, runny nose, wheezing, difficulty breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Get emergency medical help if you have signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, feeling short of breath.

Sulindac may cause serious side effects. Stop using sulindac and call your doctor right away if you have:

• changes in your vision;
• shortness of breath (even with mild exertion), swelling, rapid weight gain;
• signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
• liver problems--nausea, upper stomach pain, itching, feeling tired, flu-like symptoms, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
• pancreatitis--severe pain in your upper stomach that spreads to your back, nausea and vomiting;
• kidney problems--little or no urinating, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath; or
• low red blood cells (anemia)--pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet.

Common side effects of sulindac may include:

• nausea, vomiting, stomach pain, indigestion, loss of appetite;
• diarrhea, constipation, gas;
• headache, dizziness, nervousness;
• itching, rash; or
• ringing in your ears.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Take the medicine as soon as you can, but if it is almost time for your next dose, skip the missed dose. Do not take two doses at the same time.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

• Avoid drinking alcohol. It may increase your risk of stomach bleeding.

• Avoid taking aspirin or other NSAIDs, unless your doctor tells you to.

• Ask a doctor or pharmacist before using other medicines for pain, fever, swelling, or cold/flu symptoms. They may contain ingredients similar to sulindac (such as aspirin, ibuprofen, ketoprofen, or naproxen).

Ask your doctor before using sulindac if you take an antidepressant. Taking certain antidepressants with an NSAID may cause you to bruise or bleed easily.

Tell your doctor about all your other medicines, especially:

• cyclosporine;
• lithium;
• methotrexate;
• a blood thinner (warfarin, Coumadin, Jantoven);
• heart or blood pressure medication, including a diuretic or "water pill";
• oral diabetes medication; or
• steroid medicine (such as prednisone).

This list is not complete. Other drugs may affect sulindac, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.