Symjepi

Symjepi is used to treat severe allergic reactions (anaphylaxis) caused by insect stings or bites, foods, drugs, and other allergens.

Epinephrine auto-injectors can be kept for self-injection by someone who has had a severe allergic reaction in the past.

Epinephrine is also used to treat exercise-induced anaphylaxis or low blood pressure caused by septic shock.

Symjepi may also be used for other reasons not mentioned in this medication guide.

Seek emergency medical attention after any use of epinephrine to treat a severe allergic reaction.

After the injection you will need to receive further treatment and observation.

Before using epinephrine, inform your doctor if any previous use of Symjepi made an allergic reaction worse.

Tell your doctor if you have ever had:

• heart disease or high blood pressure;
• asthma;
• Parkinson's disease;
• depression or mental illness;
• a thyroid disorder; or
• diabetes.

Having an allergic reaction while pregnant or nursing could be harmful to both mother and baby. You may need to use epinephrine during pregnancy or while breastfeeding. Seek emergency medical help immediately after using the injection.

If possible during an emergency, inform your medical caregivers if you are pregnant or breastfeeding.

Before using epinephrine, tell your doctor if you have ever had an allergic reaction that got worse after using Symjepi.

Call your doctor right away if you notice pain, swelling, warmth, redness, or other signs of infection where you gave the injection.

Older adults may be more likely to experience side effects.

Common side effects of Symjepi may include:

• breathing problems;
• fast, irregular, or pounding heartbeats;
• pale skin, sweating;
• nausea and vomiting;
• dizziness;
• weakness or tremors;
• headache; or
• feeling restless, fearful, nervous, anxious, or excited.

This is not a complete list of side effects, and others may happen. Call your doctor for medical advice about side effects. You can report side effects to the FDA at 1-800-FDA-1088.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Epinephrine is injected into the skin or muscle of your outer thigh. In an emergency, this injection can be given through your clothing.

This medicine may come with a "trainer pen." The trainer pen contains no medicine and no needle. It is only for non-emergency use to practice giving yourself an Symjepi.

Read and follow all Instructions for Use. Ask your doctor or pharmacist if you need help.

Do not give this medicine to a child without medical advice.

The auto-injector device is a disposable single-use system. Use an auto-injector only one time.

Do not try to reinsert an auto-injector a second time. If the needle is bent from the first use, it may cause serious injury to your skin.

Seek emergency medical attention after any use of epinephrine. The effects of epinephrine may wear off after 10 or 20 minutes. You will need to receive further treatment and observation.

Also seek emergency medical attention if you accidentally inject yourself while giving epinephrine to another person.

Store at room temperature away from moisture, heat, and light. Do not refrigerate or freeze this medicine, and do not store it in a car. Do not use Symjepi if it has changed colors or has particles in it.

Do not use if the expiration date on the label has passed. Call your pharmacist for a new prescription.

Do not reuse a needle or syringe. Place them in a puncture-proof "sharps" container and dispose of it following state or local laws. Keep out of the reach of children and pets.

Since epinephrine is used as needed, it does not have a daily dosing schedule.

Seek emergency medical help or call the Poison Help line at 1-800-222-1222.

Signs of an overdose may include numbness or weakness, severe headache, blurred vision, a pounding feeling in your neck or ears, sweating, chills, chest pain, fast or slow heartbeats, severe shortness of breath, or coughing up foamy mucus.

Do not inject epinephrine into a vein or into the muscles of your buttocks, as it may not work as well. Inject it only into the fleshy outer part of the thigh.

Accidentally injecting epinephrine into your hands or feet may cause a loss of blood flow to those areas, leading to numbness.

Tell your doctor about all the other medicines you are taking, especially:

• asthma medicine;
• an antidepressant;
• cold or allergy medicine (like Benadryl and others);
• heart or blood pressure medicine;
• thyroid medication; or
• ergot medicine--dihydroergotamine, ergotamine, ergonovine, methylergonovine.

This list does not include everything. Other drugs may affect epinephrine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are mentioned here.