Syrex (Injection)

Sodium chloride 23.4% injection is used to replace lost water and salt in your body due to specific conditions (for example, hyponatremia or low salt syndrome). It is also used as an addition to total parenteral nutrition (TPN) and carbohydrate-containing IV fluids.

This medicine should only be given by your doctor or under their supervision.

It is very important that your doctor monitors your progress closely while you are receiving this medicine to ensure that it is working correctly and to check for any unwanted effects.

This medicine may cause serious issues (e.g., hypokalemia, acidosis, heart failure, pulmonary edema, or fluid retention) and these are more likely to happen if sodium chloride is given for a long time or in high doses. Talk to your doctor if you have any concerns.

In deciding to use a medicine, you and your doctor need to consider the risks of the medicine compared to its benefits. Here are some important points to think about:

Allergies

Inform your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also, let your health care professional know if you have other allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

There have not been appropriate studies on how sodium chloride 23.4% injection affects children. Safety and efficacy have not been established.

Geriatric

There is no information available on how sodium chloride 23.4% injection affects older patients.

Breast Feeding

Studies suggest that this medication poses minimal risk to infants when used during breastfeeding.

Interactions with Medicines

Some medicines should never be used together, while in other cases, two different medicines may be used together even if there is a potential interaction. In these situations, your doctor may want to adjust the dose, or other precautions may be needed. Inform your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used around the time of eating food or certain types of food due to possible interactions. Using alcohol or tobacco with certain medicines may also lead to interactions. Talk to your healthcare professional about using your medicine with food, alcohol, or tobacco.

Other Medical Problems

Having other medical problems may affect the use of this medicine. Be sure to tell your doctor if you have any other medical issues, especially:

• Bleeding problems or
• Congestive heart failure or
• Epilepsy (seizures) or
• Heart or blood vessel disease or
• Hypertension (high blood pressure) or
• Severe kidney disease or
• Liver disease (e.g., cirrhosis)—Use with caution. This may worsen these conditions or increase the chance of side effects.

• Fluid retention (swelling) or
• Hypernatremia (high sodium in the blood)—Should not be used in patients with these conditions.

• Kidney disease—Use with caution. Sodium chloride 23.4% contains aluminum, which may be toxic. The effects may be greater because the medicine is removed from the body more slowly.

Along with its necessary effects, a medicine may cause some unwanted effects. Not all of these side effects may happen, but if they do, they may require medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

• Excessive blood loss
• fever

Rare

• Anxiety
• burning pain in lower abdomen
• severe chest pain
• chills
• confusion
• cough
• dizziness
• feeling of heat
• warmth in the lips and tongue
• severe or dull headache
• loss of consciousness
• nervousness
• numbness of the fingertips
• pain in lower back, pelvis, or stomach
• ringing in the ears
• seizures
• sweating
• sudden thirst or salty taste
• vision problems
• weakness

Incidence not known

• Bad smelling discharge from the vagina
• bleeding or redness at the injection site
• decrease in the amount of urine
• decreased urine output
• dilated neck veins
• extreme tiredness or weakness
• full or bloated feeling
• increase in bleeding from the uterus
• irregular breathing or heartbeat
• pain in the lower abdomen
• passing of pieces of tissue from the uterus
• pressure in the stomach
• stomach cramping
• swelling of the abdominal or stomach area
• swelling of the face, fingers, feet, or lower legs
• tightness in the chest
• troubled breathing
• weight gain

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

• Drowsiness
• nausea
• usual tiredness or weakness
• vomiting

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Your health care professional may also be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

• Loss of appetite
• weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

In the U.S.

• Sterile Saline Diluent Tip-Lok Syringe
• Syrex

Available Dosage Forms:

• Solution

Therapeutic Class: Parenteral Electrolyte, Sodium

Find detailed information on biosimilars for this medication.

A nurse or other trained health professional will give you this medicine in a medical facility. It is given through a needle placed into one of your veins after it has been diluted.

During the procedure, you will be awake and be asked questions about how you are doing by the health care team. This helps them to react quickly to any problems you might have and to keep side effects to a minimum.

• Does salt water help mouth ulcers?