Tadliq

Tadliq is used by both men and women to treat pulmonary arterial hypertension (PAH) and to help improve exercise capacity.

Do not take Tadliq for pulmonary arterial hypertension if you are using Cialis for erectile dysfunction or symptoms of an enlarged prostate.

Tadliq may also be used for reasons not mentioned in this medication guide.

Follow all instructions on your prescription label and read all medication guides or instruction sheets. Your doctor may change your dose from time to time. Use the medicine exactly as directed.

Your dose may change if you switch to a different brand, strength, or form of this medicine. Avoid mistakes by using it exactly as directed on the label, or as prescribed by your doctor.

If you take Tadliq once a day, take it at the same time each day, with or without food.

Shake the oral suspension (liquid) for 30 seconds before measuring a dose. Measure a dose with the provided measuring device (not a kitchen spoon).

Do not use this medication more than once a day.

Do not change your Tadliq dose or stop taking this medicine. Follow your doctor's dosing instructions very carefully.

If you receive medical care for heart problems, inform your caregivers when you last took Tadliq.

This medicine does not prevent the spread of sexually transmitted diseases such as human immunodeficiency virus (HIV).

Store at room temperature, away from moisture and heat.

Some drugs can cause unwanted or dangerous effects when used with Tadliq. Tell your doctor about all your other medicines.

Stop using Tadliq and get emergency medical help if you have sudden vision loss or hearing problems.

Get emergency medical help right away if you have nausea, chest pain, or dizziness during sex.

You should not take Tadliq if you are allergic to it, or if you take other medicines for pulmonary arterial hypertension, like riociguat (Adempas).

Do not take Tadliq if you are also using certain medicines for chest pain or heart problems called nitrates. These include nitroglycerin, isosorbide dinitrate, and isosorbide mononitrate. Nitrates are also found in some recreational drugs like amyl nitrate, butyl nitrate, or nitrite ("poppers"). Taking this medicine with a nitrate can cause a sudden and serious drop in blood pressure.

Some Tadliq can stay in your bloodstream for 2 or more days after each dose you take (longer if you have liver or kidney disease). Avoid using nitrates during this time.

Tell your doctor if you have or have ever had:

• heart problems (chest pain, a heart rhythm disorder, congestive heart failure);
• a heart attack or stroke;
• pulmonary hypertension;
• bleeding problems;
• uncontrolled high or low blood pressure;
• retinitis pigmentosa (an inherited eye condition);
• problems with hearing or vision;
• a blood cell disorder like sickle cell anemia, multiple myeloma, or leukemia;
• pulmonary veno-occlusive disease (PVOD);
• a penis deformity (such as Peyronie's disease);
• priapism (an erection that is painful or lasts longer than 4 hours);
• a stomach ulcer;
• if you have been told you should not have sexual intercourse for health reasons;
• liver disease; or
• kidney disease (or if you are on dialysis).

It is not known if Tadliq will harm an unborn baby. However, having pulmonary hypertension during pregnancy may cause complications or medical problems such as heart failure and stroke in both mother and baby. Tell your doctor if you are pregnant or plan to become pregnant.

Ask a doctor if it is safe to breastfeed while using Tadliq.

Not approved for use by anyone younger than 18 years old.

Get emergency medical help if you notice signs of an allergic reaction (hives, trouble breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Tadliq may cause serious side effects. Stop using Tadliq and call your doctor immediately if you experience:

• severe vision problems, including sudden vision loss;
• feeling faint, as if you might pass out;
• ringing in your ears or sudden hearing loss;
• a painful erection or one that lasts longer than 4 hours; or
• symptoms of a heart attack—chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating.

Get emergency medical help if you experience nausea, chest pain, or dizziness during sex.

Common side effects of Tadliq may include:

• headache;
• feeling faint;
• flushing (warmth, redness, or tingly feeling);
• nausea, upset stomach;
• runny or stuffy nose; or
• muscle pain, back pain, pain in your arms or legs.

This is not a complete list of side effects, and others may occur. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at the same time.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Avoid drinking alcohol. Alcohol can further lower your blood pressure and may increase your risk of headache, dizziness, or fainting.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.

Grapefruit may interact with Tadliq and cause side effects. Avoid consuming grapefruit products.

Sometimes it is not safe to use certain medicines together. Some drugs can change the levels of other drugs in your blood, which may increase side effects or make the medicines less effective.

Tell your doctor about all your other medicines, especially:

• medicine to treat erectile dysfunction (impotence) or pulmonary arterial hypertension--riociguat, bosentan, avanafil, sildenafil, or vardenafil;
• medicine to treat chest pain--isosorbide mononitrate, isosorbide dinitrate, nitroglycerin;
• medicine to treat high blood pressure or enlarged prostate--alfuzosin, doxazosin, prazosin, terazosin, silodosin, tamsulosin;
• an antibiotic--clarithromycin, erythromycin, rifampin, or telithromycin;
• antifungal medicine--itraconazole, ketoconazole;
• HIV/AIDS medications--ritonavir and others;
• seizure medicine--carbamazepine, phenytoin, phenobarbital; or
• any other blood pressure medication.

This list is not complete and many other drugs may affect Tadliq. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

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