Technetium tc 99m pentetate (Inhalation, Intravenous)

Technetium Tc 99m pentetate injection is a radiopharmaceutical. Radiopharmaceuticals are radioactive agents that may be used to find and treat certain diseases or to study how the body's organs work.

Technetium Tc 99m pentetate injection is used to help your doctor create an image of your kidneys and check how well they are functioning. It is also used to help your doctor create an image of your brain.

Technetium Tc 99m pentetate injection is also used to help your doctor create an image of your lungs, to check how well they are functioning and to evaluate patients with blood clots in the lungs.

This medicine is to be given only by or under the direct supervision of a doctor with specialized training in nuclear medicine.

It is very important that your doctor monitors you closely while you are receiving this medicine. This will help your doctor determine if the medicine is working correctly and if you should keep using it.

While using this medicine, you may be exposed to radiation. Discuss any concerns about this with your doctor.

This medicine may cause lung or breathing issues. Inform your doctor if you experience coughing, trouble breathing, noisy breathing, shortness of breath, or chest tightness.

In deciding to use a diagnostic test, you and your doctor will weigh the risks of the test against the benefits it may provide. Other factors can also influence the results of the test. For this test, consider the following:

Allergies

Inform your doctor if you have ever had any unusual or allergic reactions to this medicine or any other medicines. Also, let your healthcare professional know about any other allergies you may have, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Studies done so far have not shown any problems specific to children that would limit the use of technetium Tc 99m pentetate injection for imaging the lungs and kidneys. However, safety and effectiveness have not been established for imaging the brain in children.

Geriatric

While studies on how age affects the impact of technetium Tc 99m pentetate injection in older adults have not been conducted, no specific problems related to aging have been reported. However, older patients are more likely to have age-related liver, kidney, or heart issues, which could require caution and possible dose adjustments for patients taking this medicine.

Breast Feeding

There are not enough studies in women to determine the risk to infants when using this medication while breastfeeding. Consider the possible benefits and risks before taking this medication during breastfeeding.

Interactions with Medicines

Some medicines should never be used together, while others may be used together even if an interaction is possible. In such cases, your doctor might adjust the dose or take other precautions. Inform your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Some medicines should not be taken around the time of eating food or specific types of food due to possible interactions. Using alcohol or tobacco with certain medicines may also cause interactions. Discuss with your healthcare professional about the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

Having other medical issues may impact the use of this diagnostic test. Be sure to inform your doctor if you have any other medical problems, especially:

• Lung or breathing problems (e.g., asthma)—Use with caution. This may worsen the condition.

• Chronic obstructive pulmonary disease (COPD)—The quality of the lung scan image may be affected in patients with this condition.

• Kidney disease—The quality of the kidney or brain scan image may be affected in patients with this condition.

Along with its necessary effects, a medicine may cause some unwanted effects. Not all of these side effects may happen, but if they do, they may require medical attention.

Check with your doctor or nurse right away if any of the following side effects occur:

Incidence not known

• Bluish color of fingernails, lips, skin, palms, or nail beds
• blurred vision
• chills
• confusion
• cough
• difficulty with swallowing
• dizziness
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• fast, pounding, or irregular heartbeat or pulse
• fever
• headache
• hives, itching, skin rash
• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• pounding in the ears
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• throat irritation
• tightness in the chest
• unusual tiredness or weakness

Some side effects may occur that usually do not require medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Your health care professional may also be able to tell you about ways to prevent or lessen some of these side effects. Check with your health care professional if any of the following side effects continue, are bothersome, or if you have any questions about them:

Incidence not known

• Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
• nausea
• vomiting

Other side effects not listed may also happen in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

In the U.S.

• An-DTPA
• MPI DTPA

A doctor or other trained health professional will give you this medicine. It is given through a needle placed into one of your veins before you have a brain or kidney scan. It may also be given using a nebulizer before you have a lung scan.

You will need to rinse your mouth, cough, and spit out the medicine from your throat after receiving it using a nebulizer.

You will need to urinate right away and as often as you can for 4 to 6 hours after receiving this medicine. Drink plenty of fluids before and after receiving this medicine so you will pass more urine. This will help flush the medicine from your body.