Tenapanor

Tenapanor is used in adults to treat irritable bowel syndrome with constipation.

Tenapanor is also used to lower phosphorus levels in the blood in adults with kidney disease who are on dialysis and have taken phosphate binders that did not work or who cannot take them.

Tenapanor may also be used for reasons not mentioned in this medication guide.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Tenapanor is taken by mouth twice a day.

Tenapanor should be taken immediately before breakfast or your first meal of the day and immediately before dinner.

If you have kidney disease and are on dialysis, do not take this medicine right before your dialysis.

Store this medicine tightly closed in the original container at room temperature, away from moisture and heat. Do not remove the canister of moisture-absorbing preservative from the original container.

Use only as directed. Inform your doctor if you are taking other medicines or have any other medical conditions or allergies.

You should not use tenapanor if you have:

• a bowel blockage.

Tenapanor should not be used in children who are younger than 6 years.

Ask a doctor or pharmacist before using tenapanor if you have health problems.

Tell your doctor if you are pregnant, plan to get pregnant, or breastfeeding.

Get emergency medical help if you have signs of an allergic reaction: hives, difficulty breathing, swelling of your face, lips, tongue, or throat.

Stop taking tenapanor and call your doctor right away if you have:

• severe diarrhea.

Common side effects of tenapanor may include:

• gas, diarrhea;
• feeling of fullness or pressure in your abdomen; or
• dizziness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Usual Adult Dose for Constipation:

50 mg orally 2 times a dayUse: Treatment of irritable bowel syndrome with constipation (IBS-C)

Usual Adult Dose for Irritable Bowel Syndrome:

50 mg orally 2 times a dayUse: Treatment of irritable bowel syndrome with constipation (IBS-C)

Skip the missed dose and take your next dose at the usual time. Do not take two doses at once.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Do not use stool softeners or laxatives with tenapanor, unless your doctor has told you to.

Other drugs may affect tenapanor, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.