Terbutaline (Subcutaneous)

Terbutaline injection is used to prevent bronchospasm in patients 12 years of age and older who have asthma, bronchitis, emphysema, and other lung diseases.

Terbutaline is part of a group of medicines called bronchodilators. Bronchodilators are medicines that relax the muscles in the bronchial tubes (air passages) of the lungs. They help relieve cough, wheezing, shortness of breath, and trouble breathing by increasing airflow through the bronchial tubes.

This medicine is available only with your doctor's prescription.

It is very important for your doctor to check the progress of you or your child during regular visits. This will help your doctor see if the medicine is working properly and check for any unwanted effects caused by the medicine.

Using this medicine to prevent or treat preterm labor can be harmful to pregnant women. This medicine may increase the risk of heart problems and other serious side effects when given to a pregnant woman for a long time. Use an effective form of birth control to prevent pregnancy. If you think you may have become pregnant while using the medicine, tell your doctor right away.

Check with your doctor immediately if you have difficulty breathing after using a dose of this medicine or if your condition worsens.

You may also be taking an anti-inflammatory medicine (e.g., corticosteroids) for asthma along with this medicine. Do not stop taking the anti-inflammatory medicine even if your asthma seems better, unless your doctor tells you to do so.

If you develop a skin rash, hives, or any allergic reaction to this medicine, stop using the medicine and contact your doctor right away.

Hypokalemia may occur while you are using this medicine. Contact your doctor immediately if you have more than one of the following symptoms: convulsions; decreased urine; dry mouth; increased thirst; irregular heartbeat; loss of appetite; mood changes; muscle pain or cramps; nausea or vomiting; numbness or tingling in the hands, feet, or lips; shortness of breath; or unusual tiredness or weakness.

This medicine may affect blood sugar levels. If you are diabetic and notice a change in your blood or urine sugar test results, contact your doctor.

Do not take other medicines unless you have discussed them with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, as well as herbal or vitamin supplements.

In deciding to use a medicine, it's important to think about the risks of taking it compared to the benefits. This is a decision you and your doctor will make together. For this medicine, consider the following:

Allergies

Inform your doctor if you have ever had any unusual or allergic reactions to this medicine or any other medicines. Also, let your healthcare professional know if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, carefully read the label or package ingredients.

Pediatric

It is not recommended to use terbutaline injection in children younger than 12 years old.

Geriatric

Studies have not found specific problems in elderly patients that would limit the use of terbutaline injection. However, older adults are more likely to have age-related kidney, liver, or heart issues, which may require caution and a dosage adjustment for those receiving terbutaline injection.

Breast Feeding

There are not enough studies in women to determine the risk to infants when using this medication during breastfeeding. Consider the potential benefits against the potential risks before taking this medicine while breastfeeding.

Interactions with Medicines

Some medicines should not be used together at all, while in other cases, two different medicines may be used together even if an interaction might happen. If you are taking this medicine, it is crucial that your healthcare professional knows if you are taking any of the medicines listed below. The following interactions are based on their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may choose not to treat you with this medication or change some of the other medicines you are taking.

• Tranylcypromine

Using this medicine with any of the following medicines is usually not recommended, but may be necessary in some cases. If both medicines are prescribed together, your doctor may adjust the dose or how often you use one or both of the medicines.

• Acebutolol
• Arotinolol
• Atenolol
• Befunolol
• Betaxolol
• Bevantolol
• Bisoprolol
• Bopindolol
• Bucindolol
• Bupranolol
• Carteolol
• Carvedilol
• Celiprolol
• Dilevalol
• Esmolol
• Iobenguane I 123
• Labetalol
• Landiolol
• Levobunolol
• Mepindolol
• Methacholine
• Metipranolol
• Metoprolol
• Nadolol
• Nebivolol
• Oxprenolol
• Penbutolol
• Pindolol
• Practolol
• Propranolol
• Sotalol
• Talinolol
• Tertatolol
• Timolol

Interactions with Food/Tobacco/Alcohol

Some medicines should not be taken at or around mealtimes, as interactions may occur. Using alcohol or tobacco with certain medicines can also lead to interactions. Talk to your healthcare professional about using your medicine with food, alcohol, or tobacco.

Other Medical Problems

Having other medical issues may affect how you use this medicine. Be sure to tell your doctor if you have any other medical problems, especially:

• Diabetes or
• Heart or blood vessel disease or
• Heart rhythm problems (e.g., arrhythmia) or
• Hypertension (high blood pressure) or
• Hyperthyroidism (overactive thyroid) or
• Hypokalemia (low potassium in the blood) or
• Ketoacidosis (high ketones in the blood) or
• Seizures—Use with caution. This may worsen these conditions.

Along with its necessary effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• Fast, irregular, pounding, or racing heartbeat or pulse
• nervousness
• shakiness in the legs, arms, hands, or feet
• trembling or shaking of the hands or feet

Less common

• Chest discomfort
• difficult or labored breathing
• feeling of warmth
• redness of the face, neck, arms, and occasionally, upper chest
• shortness of breath
• sweating
• tightness in the chest
• wheezing

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

• Arm, back, or jaw pain
• blurred vision
• chest pain
• chest tightness or heaviness
• confusion
• convulsions
• decreased urine
• dizziness
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• dry mouth
• fainting
• general feeling of discomfort or illness
• headache
• increased thirst
• loss of appetite
• mood changes
• muscle pain or cramps
• nausea or vomiting
• numbness or tingling in the hands, feet, or lips
• seizures
• sleeplessness
• trouble sleeping
• unable to sleep
• unusual tiredness or weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Drowsiness

Less common

• Pain at the injection site
• weakness

Rare

• Anxiety
• fever
• redness, soreness, or itching skin
• sores, welting, or blisters

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

In the U.S.

• Brethine

Available Dosage Forms:

• Solution

Therapeutic Class: Bronchodilator

Pharmacologic Class: Beta-2 Adrenergic Agonist

A nurse or other trained health professional will give you this medicine. This medicine is given as a shot under your skin (usually into the shoulder area).

This medicine may sometimes be given at home to patients who do not need to be in a hospital or clinic. If you are using this medicine at home, your doctor will teach you or someone who cares for you how to prepare and inject the medicine. Be sure that you understand exactly how the medicine is prepared and injected.

Use this medicine only as directed. Do not use more of it and do not use it more often than your doctor ordered. To do so may increase the chance of side effects.

If you are using this medicine for asthma, you should use another medicine that works faster for an asthma attack that has already started. If you do not have another medicine to use for an acute attack or if you have any questions about this, check with your doctor.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For injection dosage form:For prevention of bronchospasm: Adults and teenagers—0.25 milligrams (mg) injected under your skin. Your doctor may increase your dose as needed. However, the dose is usually not more than 0.5 mg within 4 hours. Children younger than 12 years of age—Use is not recommended.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store unopened vials of this medicine at room temperature, away from heat and direct light. Do not freeze. An open vial of medicine must be used right away.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Throw away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.