Tezspire Pre-filled Pen

Tezspire Pre-filled Pen is used with other medicines to help manage severe asthma in adults and children who are at least 12 years old. This medicine is not a quick-relief rescue medicine for asthma attacks.

Tezspire Pre-filled Pen is also used with other medicines to help manage the symptoms of chronic rhinosinusitis with nasal polyps (long-term sinus inflammation) in adults and children who are at least 12 years old.

Tezspire Pre-filled Pen is given after other treatments have not worked or have stopped working.

Tezspire Pre-filled Pen may also be used for reasons not mentioned in this medication guide.

Use only as directed. Inform your doctor if you are taking other medicines, have other medical conditions, or have allergies.

You should not use Tezspire Pre-filled Pen if you are allergic to it.

Tell your doctor if you have or have ever had:

• a severe allergic reaction;
• an infection caused by a parasite (helminth); or
• if you are scheduled to receive or have received a live vaccine recently.

Make sure you are up to date on all vaccines before you start using Tezspire Pre-filled Pen.

It is not known if Tezspire Pre-filled Pen will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Ask a doctor if it is safe to breastfeed while using Tezspire Pre-filled Pen.

Get emergency medical help if you have signs of an allergic reaction: hives, difficulty breathing, swelling of your face, lips, tongue, or throat.

Signs of a severe or life-threatening allergic reaction may happen right after the injection or even hours or days after using Tezspire Pre-filled Pen. Your treatment may stop if you experience this side effect.

Common side effects of Tezspire Pre-filled Pen may include:

• nosebleed;
• pain, bruising, swelling, or irritation at the injection site;
• flu or cold symptoms such as stuffy nose, sneezing, sore throat; or
• joint or back pain.

This is not a complete list of side effects, and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Tezspire Pre-filled Pen is injected under the skin, usually once every 4 weeks. A healthcare provider will give you this injection when using the vial or the prefilled syringe.

A healthcare provider may teach you how to properly use the prefilled pen by yourself. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

Prepare an injection only when you are ready to give it. Leave the needle cap on until you are ready to inject your dose. Call your pharmacist if the medicine looks cloudy, has changed colors or has particles in it.

Do not inject within 2 inches of your navel (belly button) or areas where the skin is tender, hard, scaly, damaged, bruised, or has scars. Do not inject into the same place two times in a row.

Throw away a prefilled pen after one use, even if there is still medicine left inside. Do not reuse a needle or pen. Place them in a puncture-proof "sharps" container and dispose of it following state or local laws. Keep out of the reach of children and pets.

Tezspire Pre-filled Pen is not a fast-acting rescue medicine for asthma attacks. Seek medical attention if your breathing problems get worse quickly, or if you think your medications are not working.

Do not change or stop your other medicines, including corticosteroid medicines or other asthma medicines unless your healthcare provider tells you to.

Call your doctor if your symptoms do not improve, or if they get worse.

Store this medicine in the original container in the refrigerator. Protect from light and do not freeze or shake the medicine.

Take the medicine out of the refrigerator and let it reach room temperature for 60 minutes before injecting your dose. Do not warm a pen with hot water, sunlight, or a microwave.

You may store this medicine at room temperature for up to 30 days. Throw the medicine away if not used within 30 days. Do not put it back into the refrigerator once it has reached room temperature.

Call your doctor for instructions if you miss an appointment for your Tezspire Pre-filled Pen.

If you are giving the medicine to yourself: Use it as soon as you remember, then continue with your usual schedule. If it is already time for your next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses at the same time.

Seek emergency medical help or call the Poison Help line at 1-800-222-1222.

Do not receive a "live" vaccine. The vaccine may not work as effectively while you are using Tezspire Pre-filled Pen. Live vaccines may include measles, mumps, rubella (MMR), varicella (chickenpox), live nasal flu vaccine, and others.

Other drugs may interact with Tezspire Pre-filled Pen, including prescription and over-the-counter medicines, vitamins, and herbal products. Inform your doctor about all other medicines you are taking.

Find detailed information on biosimilars for this medication.