Tigan (Intramuscular)

Trimethobenzamide is used to treat nausea and vomiting.

This medicine is available only with your doctor's prescription.

Trimethobenzamide will increase the effects of alcohol and other CNS depressants (medicines that make you sleepy or less alert). Some examples of CNS depressants include antihistamines or medicines for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicines; prescription pain medicines or narcotics; barbiturates; medicines for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Talk to your doctor before taking any of these medicines while you are using trimethobenzamide.

This medicine may make some people feel dizzy, lightheaded, drowsy, or less alert than usual. Be sure to know how this medicine affects you before you drive, operate machinery, or do anything else that could be dangerous if you are dizzy or not alert.

In deciding to use a medicine, you and your doctor need to think about the risks and benefits. Here are some important points to consider:

Allergies

Inform your doctor if you have ever had any unusual or allergic reactions to this medicine or any other medicines. Also, let your healthcare professional know if you have any other allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients closely.

Pediatric

There is no information on how age affects the use of intramuscular trimethobenzamide in children. However, because this medication can be harmful, it is not allowed for use in children. Intramuscular trimethobenzamide should never be used in children.

Geriatric

There is no information on whether the risk of side effects from trimethobenzamide is higher in elderly patients. However, due to this medication's toxicity, it should be used carefully, only after considering and/or trying less toxic alternatives. Recommended doses must not be exceeded, and patients should be closely monitored during treatment.

Breast Feeding

There are no adequate studies in women to assess the risk to infants when using this medication while breastfeeding. Consider the potential benefits and risks before taking this medicine while breastfeeding.

Interactions with Medicines

Some medicines should not be used together at all, while in other situations, two different medicines may be used together even if some interaction might happen. In these cases, your doctor may want to adjust the dose, or other precautions may be needed. While using this medicine, it is very important that your healthcare professional knows if you are taking any of the following medicines. The interactions listed below are chosen for their potential importance and may not include all possible interactions.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide to not treat you with this medication or change some of your other medicines.

• Bromopride
• Potassium Citrate

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used around mealtime or with specific foods due to possible interactions. Using alcohol or tobacco with certain medicines may also lead to interactions. Talk to your healthcare professional about using this medicine with food, alcohol, or tobacco.

Other Medical Problems

Having other medical problems may influence the use of this medicine. Make sure to inform your doctor if you have any other medical issues, especially:

• Dehydration or
• Electrolyte imbalance (high or low levels of minerals in the blood) or
• High fever or
• Severe intestinal infection—May worsen side effects.

Along with its necessary effects, a medicine may cause some unwanted effects. Although not all of these side effects may happen, if they do occur, they might need medical attention.

Check with your doctor right away if any of the following side effects happen:

Rare

• Body spasm, with head and heels bent backward and body bowed forward
• convulsions (seizures)
• depression
• shakiness or tremors
• skin rash
• sore throat or fever
• unusual tiredness
• vomiting (severe or continuing)
• yellow eyes or skin

Some side effects may happen that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Your health care professional may also be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Drowsiness

Less common

• Blurred vision
• diarrhea
• dizziness
• headache
• muscle cramps

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

In the U.S.

• Arrestin
• Benzacot
• Stemetic
• Ticon
• Tigan
• Tribenzagan

Available Dosage Forms:

• Solution

Therapeutic Class: Antiemetic

Pharmacologic Class: Anticholinergic

Trimethobenzamide is only used to relieve or prevent nausea and vomiting. A nurse or other trained health professional will give you this medicine. This medicine is given as a shot into one of your muscles.

Your doctor may only give you a few doses of this medicine until your condition improves, and then may switch you to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor.