Tolterodine

Tolterodine is used in adults to treat overactive bladder that causes urinary frequency, urgency, and incontinence (urine leakage).

Tolterodine may also be used for reasons not mentioned in this medication guide.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Take with water.

Take tolterodine with or without food, at the same times each day.

Swallow the capsule whole and do not crush, chew, break, or open it.

Store at room temperature away from moisture, heat, and light.

Use only as directed. Inform your doctor if you are taking other medicines or have other medical conditions or allergies.

You should not use tolterodine if you are allergic to tolterodine or fesoterodine (Toviaz), or if you have:

• trouble emptying your bladder;
• a blockage in your stomach, slow digestion; or
• uncontrolled narrow-angle glaucoma.

Tell your doctor if you have ever had:

• a stomach or intestinal disorder;
• problems with constipation;
• liver disease;
• kidney disease;
• myasthenia gravis;
• trouble emptying your bladder, or a weak stream of urine;
• glaucoma; or
• long QT syndrome (in you or a family member).

Tell your doctor if you are pregnant or breastfeeding.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tolterodine may cause serious side effects. Stop using tolterodine and call your doctor right away if you have:

• confusion, hallucinations;
• severe stomach pain or constipation; or
• painful or difficult urination.

Common side effects of tolterodine may include:

• dry mouth;
• dizziness;
• constipation;
• stomach pain; or
• headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Usual Adult Dose for Urinary Incontinence:

Immediate release tablets:-Initial dose: 2 mg orally 2 times a day-Maintenance dose: 1 to 2 mg orally 2 times a day, depending on patient response and tolerabilityExtended release capsules: -Initial dose: 4 mg orally once a day-Maintenance dose: 2 to 4 mg orally once a day, depending on patient response and tolerabilityComments:-This drug can be taken with or without food.-The extended release formulation should be swallowed whole.Use: For the treatment of overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and frequency

Usual Adult Dose for Urinary Frequency:

Immediate release tablets:-Initial dose: 2 mg orally 2 times a day-Maintenance dose: 1 to 2 mg orally 2 times a day, depending on patient response and tolerabilityExtended release capsules: -Initial dose: 4 mg orally once a day-Maintenance dose: 2 to 4 mg orally once a day, depending on patient response and tolerabilityComments:-This drug can be taken with or without food.-The extended release formulation should be swallowed whole.Use: For the treatment of overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and frequency

Skip the missed dose and take your next dose at the regular time. Do not take 2 doses in one day.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Avoid driving or engaging in hazardous activities until you understand how tolterodine will affect you. Your reactions might be impaired.

Tolterodine can lead to a serious heart issue. Your risk may increase if you are also taking certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV.

Inform your doctor about all your other medicines, especially:

• cyclosporine; or
• vinblastine.

This list is not complete. Other drugs may impact tolterodine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all potential drug interactions are included here.