Trandolapril

Trandolapril is used in adults by itself or with other medications to treat high blood pressure and to help improve survival after a heart attack.

Trandolapril may also be used for reasons not mentioned in this medication guide.

Follow all instructions on your prescription label and read all medication guides or instruction sheets. Your doctor may change your dose from time to time. Use the medicine exactly as directed.

You may take trandolapril with or without food.

Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking trandolapril. This can lead to very low blood pressure, an electrolyte imbalance, or kidney failure.

Your blood pressure will need to be checked often, and you may need frequent blood tests.

Tell your doctor if you have a planned surgery.

If you have high blood pressure, keep using trandolapril even if you feel well. High blood pressure often has no symptoms.

Store tightly closed at room temperature, away from moisture and heat.

Do not use if you are pregnant.

Stop using trandolapril and tell your doctor right away if you become pregnant.

Tell your doctor about all your other medicines. Some drugs should not be used with trandolapril.

You should not use trandolapril if you are allergic to it or to any other ACE (angiotensin converting enzyme) inhibitor such as benazepril, captopril, fosinopril, enalapril, lisinopril, moexipril, perindopril, quinapril, or ramipril.

Do not take trandolapril within 36 hours before or after taking medicine that contains sacubitril (such as Entresto).

Do not take trandolapril if you have a history of angioedema (severe allergic reaction).

If you have diabetes, do not take trandolapril with any medication that contains aliskiren (a blood pressure medicine).

Tell your doctor if you have ever had:

• heart disease or congestive heart failure;
• stomach pain;
• low blood pressure;
• low white blood cell count;
• if you are on a low-salt diet;
• diabetes;
• liver disease; or
• kidney disease (or if you are on dialysis).

You may also need to avoid taking trandolapril with aliskiren if you have kidney disease.

Stop using this medicine and tell your doctor right away if you become pregnant. Trandolapril can cause injury or death to the unborn baby if you use the medicine during your second or third trimester.

Do not breastfeed.

Get emergency medical help if you have signs of an allergic reaction: hives, severe stomach pain, difficulty breathing, swelling of your face, lips, tongue, or throat.

Trandolapril may cause serious side effects. Call your doctor right away if you experience:

• a light-headed feeling, like you might faint;
• chest pain, fast, slow, or uneven heart rate;
• kidney problems--swelling, urinating less, feeling tired or short of breath;
• high blood potassium--nausea, weakness, tingling, chest pain, irregular heartbeats, loss of movement;
• liver problems--loss of appetite, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
• low white blood cell counts--fever, mouth sores, skin sores, sore throat, cough.

Common side effects of trandolapril may include:

• cough;
• headache, dizziness;
• low blood pressure; or
• diarrhea.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Take the medicine as soon as you can, but if it is nearly time for your next dose, skip the missed dose. Do not take two doses at the same time.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

• Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.

• Do not use potassium supplements or salt substitutes, unless your doctor has told you to.

• Avoid becoming overheated or dehydrated during exercise, in hot weather, or by not drinking enough fluids. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

Trandolapril can damage your kidneys, especially if you are also taking certain medicines for infections, cancer, or osteoporosis.

Make sure to tell your doctor about all the other medicines you are taking, especially:

• a diuretic or "water pill" that may raise blood potassium such as spironolactone, triamterene, amiloride;
• NSAIDs (nonsteroidal anti-inflammatory drugs) like aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others;
• insulin or diabetes medications;
• medicine to prevent organ transplant rejection like temsirolimus, sirolimus, or everolimus; or
• heart or blood pressure medication.

This list is not complete. Other drugs may affect trandolapril, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are mentioned here.