Tranexamic acid (Intravenous)

Tranexamic acid injection is used to manage or stop heavy bleeding during dental procedures in patients with hemophilia.

Tranexamic acid injection is an antifibrinolytic agent. It works by preventing the breakdown of blood clots. Your doctor may also use it for other conditions.

This medicine should only be given by your doctor or under their direct supervision.

It is very important that your doctor checks your or your child's progress closely while receiving this medicine to ensure it is working properly and to decide if you should keep using it. Blood and urine tests may be needed to check for side effects.

This medicine may increase your or your child's risk of developing blood clots. Contact your doctor immediately if you or your child experience swelling and pain in the arms, legs, or stomach, chest pain, trouble breathing, loss of sensation, confusion, or issues with muscle control or speech.

Taking this medicine alongside birth control pills may also raise your risk of blood clots. Use another form of birth control (including condoms, spermicide) to avoid pregnancy.

This medicine may increase the risk of seizures. This risk is more likely if you are having surgery for a heart or blood vessel issue. Discuss any concerns with your doctor.

This medicine may cause a serious allergic reaction called anaphylaxis, which can be life-threatening and requires immediate medical attention. Notify your doctor right away if you have a rash, itching, hoarseness, trouble breathing or swallowing, or any swelling of your hands, face, or mouth after receiving this medicine.

If you or your child will be receiving tranexamic acid injection for more than several days, your doctor may want you to have your eyes checked regularly by an ophthalmologist (eye doctor). Blurred vision, difficulty reading, or any other changes in vision may happen during or after treatment with this medicine.

This medicine may cause dizziness. Do not drive or engage in any potentially dangerous activities until you know how this medicine affects you.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or non-prescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

In deciding to use a medicine, you and your doctor need to consider the risks of taking the medicine against its benefits. Here are some things to think about for this medicine:

Allergies

Inform your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also let your healthcare provider know if you have any other types of allergies, like to foods, dyes, preservatives, or animals. For non-prescription products, carefully read the label or package ingredients.

Pediatric

Studies so far have not shown any specific problems in children that would limit the use of tranexamic acid injection in this age group.

Geriatric

Studies so far have not shown any specific problems in older adults that would limit the use of tranexamic acid injection in the elderly. However, older patients are more likely to have kidney problems related to aging, which may require caution when receiving this medicine.

Breast Feeding

There are no adequate studies in women to determine the risk to infants when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Some medicines should not be used together at all, while others may be used together even if there is a chance of interaction. In these cases, your doctor may adjust the dose or take other precautions. It is particularly important for your healthcare provider to know if you are taking any of the medicines listed below while you are receiving this medicine. The following interactions have been chosen based on their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may choose not to treat you with this medication or adjust some of your other medicines.

• Desogestrel
• Dienogest
• Drospirenone
• Estradiol
• Ethinyl Estradiol
• Ethynodiol
• Etonogestrel
• Gestodene
• Levonorgestrel
• Medroxyprogesterone
• Mestranol
• Nomegestrol
• Norelgestromin
• Norethindrone
• Norgestimate
• Norgestrel
• Segesterone
• Ulipristal

Using this medicine with any of the following medicines is usually not recommended, but may be necessary in some situations. If both medicines are prescribed together, your doctor may adjust the dose or frequency of one or both medicines.

• Anti-Inhibitor Coagulant Complex
• Chlorpromazine
• Tretinoin

Interactions with Food/Tobacco/Alcohol

Some medicines should not be taken around the time of eating food or certain types of food due to possible interactions. Using alcohol or tobacco with certain medicines may also lead to interactions. Discuss with your healthcare provider about using your medicine with food, alcohol, or tobacco.

Other Medical Problems

Having other medical problems may affect how you can use this medicine. Make sure to tell your doctor if you have any other medical issues, especially:

• Blood clots, active or
• Subarachnoid hemorrhage (bleeding in the brain)—This medicine should not be used in patients with these conditions.

• Eye or vision problems or
• History of seizures—Use with caution. This medicine may worsen these conditions.

• Kidney disease—Use with caution. The effects may be stronger because the medicine may be removed from the body more slowly.

Along with its necessary effects, this medicine may cause some unwanted effects. Not all of these side effects may happen, but if they do, you may need medical attention.

Check with your doctor or nurse right away if any of the following side effects happen:

Incidence not known

• Anxiety
• Bloody or cloudy urine
• Blurred or loss of vision
• Changes in vision
• Chest pain or tightness
• Confusion
• Cough
• Difficult or painful urination
• Difficulty swallowing
• Disturbed color perception
• Dizziness, fainting, or lightheadedness when standing up quickly from a lying or sitting position
• Double vision
• Fast heartbeat
• Halos around lights
• Hives, itching, skin rash
• Migraine headache
• Night blindness
• Numbness of the hands
• Overbright appearance of lights
• Pain, redness, or swelling in the arm or leg
• Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• Redness of the skin
• Seizures
• Sudden decrease in the amount of urine
• Sweating
• Trouble breathing
• Tunnel vision
• Unusual tiredness or weakness

Some side effects may happen that usually do not need medical attention. These side effects may go away during treatment as your body gets used to the medicine. Also, your healthcare professional may be able to tell you how to prevent or reduce some of these side effects. Check with your healthcare professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

• Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at injection site
• Diarrhea
• Giddiness
• Nausea
• Vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

In the U.S.

• Cyklokapron

Available Dosage Forms:

• Solution

Therapeutic Class: Hemostatic

A nurse or other trained health professional will give you this medicine in a medical facility. It is given through a needle placed into one of your veins. This medicine is for short-term use only, usually 2 to 8 days.