Treprostinil

Treprostinil is used in adults to treat high blood pressure in the arteries of the lungs, which is also called pulmonary arterial hypertension (PAH). Treprostinil improves your ability to exercise and can help prevent your condition from worsening.

Treprostinil may also be used for reasons not mentioned in this medication guide.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Take with food.

Swallow the tablet whole and do not crush, chew, or break it. Do not use a cracked or broken tablet.

Treprostinil is usually taken 2 to 3 times per day. Follow your doctor's instructions. Your dose may change if you have side effects.

Use treprostinil regularly for the best results.

Your dose needs may change if you switch to a different brand, strength, or form of this medicine. Avoid medication errors by using only the medicine your doctor prescribes.

You should not stop taking treprostinil suddenly. Your condition may get worse if you stop taking treprostinil. Follow your doctor's instructions about tapering your dose.

Part of a tablet shell may appear in your stool but this will not make the medicine less effective.

Store at room temperature away from moisture and heat.

You should not use treprostinil if you have severe liver disease.

You should not stop taking treprostinil suddenly. Your condition may worsen if you stop taking treprostinil.

You should not use treprostinil if you have severe liver disease.

Tell your doctor if you have or have ever had:

• diverticulosis (an intestinal disorder); or
• liver disease.

It is not known if treprostinil will harm an unborn baby. However, having high lung blood pressure during pregnancy may cause complications or medical problems for both mother and baby. The benefit of treating pulmonary hypertension may outweigh any risks to the baby.

Ask a doctor if it is safe to breastfeed while using treprostinil.

Get emergency medical help if you have signs of an allergic reaction: hives, difficulty breathing, swelling of your face, lips, tongue, or throat.

Treprostinil may cause serious side effects. Call your doctor right away if you have:

• chest pain, trouble breathing, tiredness, pale skin, swelling in your arms or legs; or
• a light-headed feeling, like you might faint.

Common side effects of treprostinil may include:

• headache;
• stomach pain;
• jaw pain, pain in your arms or legs;
• diarrhea, nausea, vomiting; or
• flushing (sudden warmth, redness, or tingling feeling).

This is not a complete list of side effects and others may happen. Call your doctor for medical advice about side effects. You can report side effects to the FDA at 1-800-FDA-1088.

Take the medicine as soon as you can, but skip the missed dose if it is nearly time for your next dose. Do not take two doses at once.

Call your doctor for instructions if you miss 2 or more doses of treprostinil.

Seek emergency medical help or call the Poison Help line at 1-800-222-1222.

Follow your doctor's instructions regarding any limits on food, drinks, or activities.

Tell your doctor about all your other medicines, especially:

• gemfibrozil; or
• medicine that contains treprostinil--Remodulin, Tyvaso, or Tyvaso DPI.

This list is not complete. Other drugs may affect treprostinil, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.