Treprostinil (inhalation)

Treprostinil is used to treat pulmonary arterial hypertension (PAH) and pulmonary hypertension associated with interstitial lung disease (PH-ILD) in adults. Treprostinil improves your ability to exercise and can help prevent your condition from getting worse.

Treprostinil may also be used for reasons not mentioned in this medication guide.

Use only as directed. Inform your doctor if you are taking other medicines or have any other medical conditions or allergies.

Tell your doctor if you have or have ever had:

• bronchospasm (wheezing, chest tightness, trouble breathing);
• low blood pressure;
• asthma, COPD, sleep apnea, or other breathing disorder;
• bleeding problems; or
• liver disease.

Tell your doctor if you are pregnant. Having pulmonary hypertension during pregnancy may increase the risk of complications for both mother and baby. The benefit of treating pulmonary hypertension may outweigh any risks to the baby.

Ask a doctor if it is safe to breastfeed while using treprostinil.

Get emergency medical help if you notice signs of an allergic reaction: hives, trouble breathing, swelling of your face, lips, tongue, or throat.

Treprostinil may lead to serious side effects. Contact your doctor immediately if you experience:

• a light-headed feeling, as if you might faint; or
• easy bruising or bleeding (such as nosebleeds or bleeding gums).

Common side effects of treprostinil may include:

• cough, throat pain or irritation after use;
• dizziness or feeling light-headed;
• shortness of breath;
• nausea, diarrhea;
• headache; or
• flushing (sudden warmth, redness, or tingling sensation).

This is not a complete list of side effects and others may happen. Reach out to your doctor for medical advice about side effects. You can report side effects to the FDA at 1-800-FDA-1088.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Your dose needs may change if you switch to a different brand, strength, or form of this medicine. Avoid medication errors by using exactly as directed on the label, or as prescribed by your doctor.

Do not swallow this medicine. The medicine should be inhaled only using the inhalation system provided with the medication.

Do not use or mix other medicines with treprostinil inhalation.

Treprostinil inhalation is usually given at evenly spaced intervals during waking hours. Use exactly as directed on the label, or as prescribed by your doctor.

Read and carefully follow any instructions for setting up and using the medicine before preparing your first dose. Ask your doctor or pharmacist if you do not understand these instructions.

The effects of treprostinil inhalation will lessen over time between doses. Talk with your doctor if you need to time your dosing around any planned activities.

Follow all storage and cleaning instructions provided with treprostinil inhalation. Your pharmacist can provide more information about how to store this medicine.

Make sure you have a backup inhalation system available in case one of the systems stops working.

Use the medicine as soon as you can. Do not use two doses at the same time.

Seek emergency medical help or call the Poison Help line at 1-800-222-1222.

Do not let treprostinil get in your eyes. Rinse with water if this medicine comes into contact with your eyes.

Do not shake or drop the inhaler. Keep the inhaler upright with the mouthpiece facing up.

Avoid letting this medicine touch your skin. If it does, wash the area right away with soap and water.

Be careful not to get up too quickly from a sitting or lying position, or you may feel dizzy.

Sometimes it is not safe to use certain medicines together. Some drugs can change the blood levels of other drugs you take, which may increase side effects or make the medicines less effective.

Other drugs may affect treprostinil (inhalation), including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you are using.