On this page · 9 sections
- What is triamcinolone acetonide cream and ointment?
- Warnings
- Before taking this medicine
- Triamcinolone acetonide cream side effects
- How should I use triamcinolone acetonide topical?
- What happens if I miss a dose?
- What happens if I overdose?
- What other drugs will affect this medication?
- Triamcinolone acetonide FAQ
Triamcinolone Acetonide Cream
Brand names: Kenalog, Oralone, Trianex, Triderm, Aristocort A, Rx, Aristocort Topical, Kenalog in Orabase, Kourzeq
What is triamcinolone acetonide cream and ointment?
Triamcinolone acetonide cream and ointment are potent corticosteroids used for psoriasis, eczema, dermatitis, and allergic rashes to reduce inflammation, itching, redness, and swelling.
Triamcinolone acetonide works by acting like cortisol, a natural anti-inflammatory hormone your adrenal glands make. It reduces inflammation by calming the immune response, which helps relieve itching, redness, and swelling.
Triamcinolone acetonide cream and ointments are prescription medicines; they are not available over the counter (OTC) without a prescription. It may be prescribed as a brand name, such as Triderm and Trianex, or as a generic medicine.
Triamcinolone acetonide is also available as a dental paste, injection, intra-articular injection (Zilretta), and nasal spray (Nasacort).
Warnings
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
Prolonged use of topical corticosteroids may cause atrophy of the epidermis and subcutaneous tissue; these effects are most likely to occur (even with short-term use) in intertriginous (e.g., axilla, groin), flexor, and facial areas.
Infections: If a skin infection develops or is present, anti-infective therapy should be started. If it does not respond promptly, discontinue topical corticosteroid therapy until the infection has been controlled.
Hypothalamic-Pituitary-Adrenal Axis Suppression: Topically applied corticosteroids can be absorbed in sufficient amounts to reversibly suppress the HPA axis. Perform periodic HPA-axis evaluation by appropriate testing (e.g., ACTH stimulation, morning plasma cortisol, urinary free cortisol), especially in patients applying a topical corticosteroid to a large surface area or to areas under occlusion.
Systemic Effects. Systemic absorption following topical administration may result in manifestations of Cushing's syndrome, hyperglycemia, and glucosuria in some patients. Infants and children may be more susceptible to adverse systemic effects.
Local Effects. Possible adverse local reactions (e.g., burning, itching, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, skin atrophy, striae, miliaria); may occur more frequently with the use of occlusive dressings, especially with prolonged therapy.
Occlusive Dressings. Adverse systemic corticosteroid effects may occur with use of occlusive dressings on large areas of the body and for prolonged periods of time; monitor accordingly
Before taking this medicine
You should not use triamcinolone acetonide cream if you are allergic to the active ingredients or any inactive ingredients.
Tell your doctor if you have ever had:
- any type of skin infection;
- a skin reaction to any steroid medicine;
- liver disease; or
- an adrenal gland disorder.
Steroid medicines can increase the glucose (sugar) levels in your blood or urine. Tell your doctor if you have diabetes.
Tell your doctor if you are pregnant or breastfeeding. If you apply triamcinolone to your chest, avoid areas that may come into contact with the nursing baby's mouth.
Triamcinolone acetonide cream side effects
Common triamcinolone acetonide cream side effects
Common triamcinolone acetonide cream side effects include:
- burning, itching, dryness, or other irritation of treated skin;
- redness or crusting around your hair follicles;
- redness or itching around your mouth;
- allergic skin reaction;
- stretch marks;
- acne, increased body hair growth;
- thinning skin or discoloration; or
- white or "pruned" appearance of the skin (caused by covering treated skin with a tight bandage or other covering).
Serious triamcinolone acetonide cream side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Triamcinolone acetonide cream may cause other serious side effects. Call your doctor at once if you have:
- worsening of your skin condition;
- redness, warmth, swelling, oozing, or severe irritation of any treated skin;
- blurred vision, tunnel vision, eye pain, or seeing halos around lights;
- high blood sugar - increased thirst, increased urination, dry mouth, fruity breath odor; or
- possible signs of absorbing triamcinolone topical through your skin or gums--weight gain (especially in your face or your upper back and torso), slow wound healing, thinning or discolored skin, increased body hair, muscle weakness, nausea, diarrhea, tiredness, mood changes, menstrual changes, sexual changes.
Children can absorb larger amounts of this medicine through the skin and may be more likely to have side effects such as growth delay, headaches, or pain behind the eyes. A baby using this medicine may have a bulging soft spot (the top of the head where the skull hasn't yet grown together).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
How should I use triamcinolone acetonide topical?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Triamcinolone acetonide cream should only be applied to skin, avoid contact with the eyes.
Triamcinolone acetonide cream and ointment directions
Apply triamcinolone acetonide cream 0.1%, 0.5%, 0.025%, or triamcinolone acetonide ointment sparingly in a thin film and rub gently into the affected area. Apply as often as your doctor has prescribed. Do not apply this medicine over a large area of skin unless your doctor has told you to.
Do not cover the treated skin area with a bandage or other covering unless your doctor tells you to. Covering treated areas can increase the amount of medicine absorbed through your skin and may cause harmful effects.
Use the triamcinolone acetonide cream 0.5% and ointment 0.5% only in the treatment of dermatoses that are refractory to treatment with lower concentrations.
Wash your hands before and after using triamcinolone topical unless you are using this medicine to treat the skin on your hands.
Call your doctor if your symptoms do not improve or if they get worse.
Triamcinolone dental paste directions
Triamcinolone acetonide paste is applied directly onto an ulcer inside the mouth and left in place. To use the dental paste, press a small dab onto the mouth ulcer, but do not rub in the medicine. The dab will form a thin film that should be left in place for several hours. Triamcinolone dental paste is usually applied at bedtime and/or after meals. Follow your doctor's instructions. A mouth ulcer should improve within 1 week of using triamcinolone dental paste.
You should stop using this medicine once your symptoms are controlled.
Store at room temperature, away from moisture and heat.
What happens if I miss a dose?
Apply the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not apply two doses at one time.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication.
High doses or long-term use of steroid medicine can lead to thinning skin, easy bruising, changes in body fat (especially in your face, neck, back, and waist), increased acne or facial hair, menstrual problems, impotence, or loss of interest in sex.
Avoid getting triamcinolone topical in your eyes.
Avoid using other topical steroid medications on the areas you treat with triamcinolone unless your doctor tells you to.
Do not use triamcinolone topical to treat any condition that has not been checked by your doctor.
Do not share this medicine with another person, even if they have the same symptoms you have.
What other drugs will affect this medication?
Medicine used on the skin is not likely to be affected by other drugs you use. But many drugs can interact with each other. Tell each of your healthcare providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.
Triamcinolone acetonide FAQ
What is triamcinolone acetonide used for?It is commonly used to relieve redness, itching, swelling, and inflammation from corticosteroid-responsive skin conditions.
Is triamcinolone acetonide a steroid?Yes. It is a topical corticosteroid, sometimes called a cortisone-like medicine.
How does triamcinolone acetonide work?It calms the body’s inflammatory response, helping reduce itching, redness, and swelling.
Is triamcinolone acetonide available over the counter?No. In the U.S., topical triamcinolone is available only with a prescription.
How do I apply triamcinolone acetonide cream or ointment? Patients usually apply a thin layer to the affected skin as directed by their healthcare provider.
How long does triamcinolone acetonide take to work?Some people notice improvement within a few days, but timing depends on the condition being treated and how severe it is.
How long can I use triamcinolone acetonide?It should be used only for the length of time prescribed. Long-term or widespread use can increase the risk of side effects.
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Content is provided for education and is not medical advice. See our medical disclaimer. Source page medically reviewed by Melisa Puckey, BPharm on April 30, 2026.