Tribenzagan (Intramuscular)

Trimethobenzamide is used to help with nausea and vomiting.

This medicine is available only with your doctor's prescription.

Trimethobenzamide will increase the effects of alcohol and other CNS depressants (medicines that make you sleepy or less alert). Some examples of CNS depressants include antihistamines or medicines for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicines; prescription pain medicines or narcotics; barbiturates; medicines for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Talk to your doctor before taking any of these medicines while you are using trimethobenzamide.

This medicine may make some people feel dizzy, lightheaded, drowsy, or less alert than usual. Make sure you understand how this medicine affects you before driving, operating machinery, or doing anything else that could be dangerous if you feel dizzy or are not alert.

In deciding to use a medicine, you and your doctor need to consider the risks of the medicine against the benefits it offers. Here are some important things to think about:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also inform your healthcare professional about any other kinds of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

There is no information on how age affects the use of intramuscular trimethobenzamide in children. However, due to the toxicity of this medication, it is not safe for use in children. Intramuscular trimethobenzamide should never be used in children.

Geriatric

There is no information on whether older adults are at a higher risk for adverse effects from trimethobenzamide. However, due to the toxicity of this medication, it should be used with caution in elderly patients, especially after considering and/or trying less toxic alternatives. Recommended doses should not be exceeded, and patients should be closely monitored during treatment.

Breast Feeding

There are no adequate studies in women to determine the risk to infants when using this medication while breastfeeding. Weigh the potential benefits against the possible risks before taking this medication during breastfeeding.

Interactions with Medicines

Some medicines should not be used together at all, while others may be used together even if there is a chance of interaction. In these cases, your doctor may want to adjust the dose, or take other precautions. It is very important for your healthcare professional to know if you are taking any of the medicines listed below while receiving this medicine. The following interactions have been chosen based on their potential significance and are not necessarily a complete list.

Using this medicine with any of the following medicines is not recommended. Your doctor may choose not to treat you with this medication or may change some of the other medicines you take.

• Bromopride
• Potassium Citrate

Interactions with Food/Tobacco/Alcohol

Some medicines should not be taken at the same time as food or certain types of food due to possible interactions. Using alcohol or tobacco with certain medicines can also cause interactions. Talk to your healthcare professional about using your medicine with food, alcohol, or tobacco.

Other Medical Problems

Having other medical problems may affect how this medicine works for you. Make sure to inform your doctor if you have any other medical conditions, especially:

• Dehydration or
• Electrolyte imbalance (high or low levels of minerals in the blood) or
• High fever or
• Severe intestinal infection—These may worsen side effects.

Along with its necessary effects, a medicine may cause some unwanted effects. Not all of these side effects may happen, but if they do, they may require medical attention.

Check with your doctor right away if any of the following side effects occur:

Rare

• Body spasm, with head and heels bent backward and body bowed forward
• convulsions (seizures)
• depression
• shakiness or tremors
• skin rash
• sore throat or fever
• unusual tiredness
• vomiting (severe or continuing)
• yellow eyes or skin

Some side effects may happen that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Your health care professional may also be able to tell you how to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Drowsiness

Less common

• Blurred vision
• diarrhea
• dizziness
• headache
• muscle cramps

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

In the U.S.

• Arrestin
• Benzacot
• Stemetic
• Ticon
• Tigan
• Tribenzagan

Available Dosage Forms:

• Solution

Therapeutic Class: Antiemetic

Pharmacologic Class: Anticholinergic

Trimethobenzamide is only used to relieve or prevent nausea and vomiting. A nurse or other trained health professional will give you this medicine. This medicine is given as a shot into one of your muscles.

Your doctor may only give you a few doses of this medicine until your condition improves, and then may switch you to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor.