Trilaciclib

Trilaciclib is used to help prevent bone marrow suppression in people getting chemotherapy with specific medicines for small cell lung cancer.

Trilaciclib may also be used for reasons not mentioned in this medication guide.

Trilaciclib is given as an infusion into a vein, usually within 4 hours before your chemotherapy infusion starts. A healthcare provider will give you this injection.

Trilaciclib must be administered slowly, and the infusion can take at least 30 minutes to finish.

Call your doctor right away if you have pain, redness, warmth, itching, swelling, bruising, or any changes in the skin where the medicine was injected.

You should not be treated with trilaciclib if you are allergic to it.

Tell your doctor if you have ever had liver problems.

Trilaciclib may harm an unborn baby. Use effective birth control to prevent pregnancy while you are using trilaciclib and for at least 3 weeks after your last dose. Tell your doctor if you become pregnant.

You should not breastfeed while using trilaciclib and for at least 3 weeks after your last dose.

Get emergency medical help if you notice signs of an allergic reaction: hives, itching; difficulty breathing; swelling of your eyes, face, lips, tongue, or throat.

Trilaciclib may cause serious side effects. Contact your doctor immediately if you experience:

• pain, redness, warmth, itching, swelling, bruising, or skin changes where the medicine was injected;
• fever, chills, cough with mucus;
• sudden chest pain, wheezing, dry cough, feeling short of breath;
• low calcium level—muscle spasms or contractions, numbness or tingling (around your mouth, or in your fingers and toes); or
• low potassium level—leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or feeling limp.

Your trilaciclib treatments may be delayed or stopped permanently if you have certain side effects.

Common side effects of trilaciclib may include:

• low levels of calcium or potassium;
• headache;
• breathing problems;
• feeling tired; or
• abnormal liver function tests.

This is not a complete list of side effects and others may occur. Contact your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Usual Adult Dose for Chemotherapy Toxicity:

240 mg/m2 IV over 30-minute completed within 4 hours prior to the start of chemotherapy dayComments: -Interval between doses of this drug on sequential days should not be greater than 28 hours.-For a is missed, discontinue chemotherapy that day and consider resuming both this drug and the chemotherapy on the next scheduled chemotherapy day.-If this drug is discontinued, wait 96 hours from the last dose of this drug before resuming the chemotherapy regimen alone.Use: -To decrease the incidence of chemotherapy-induced myelosuppression in adult patients when administered prior to a platinum/etoposide-containing regimen or topotecan containing regimen for extensive-stage small cell lung cancer

Call your doctor for instructions if you miss an appointment for your Trilaciclib injection.

Since trilaciclib is administered by a healthcare professional in a medical setting, an overdose is unlikely to happen.

Follow your doctor's instructions regarding any limitations on food, drinks, or activities.

Tell your doctor about all your other medicines, especially:

• cisplatin;
• dalfampridine; or
• dofetilide.

This list is not complete. Other drugs may affect trilaciclib, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.